Abstract：
:Smoking women are probably at a higher risk to develop lung cancer than men. Different explanations exist for these findings, a gender-specific impairment of tobacco carcinogen metabolism being one of them. In this study, we examined the inhibition of NNK reduction to NNAL, the first and most important detoxication step of this tobacco-specific carcinogen. It is mediated by different carbonyl reductases of the SDR (CBR1 and 11βHSD1) and AKR (AKR1B10, AKR1C1, AKR1C2 and AKR1C4) superfamilies. Inhibition constants of NNK reduction were determined with male (testosterone) and female (estradiol, progesterone) sex hormones and the contraceptives ethinylestradiol and drospirenone in A549 cells and with purified enzymes. Female sex hormones turned out to be stronger inhibitors than testosterone. The gestagen progesterone and its synthetic derivative drospirenone are the strongest inhibitors with Ki-values similar to hormone levels in pregnant women or women using hormonal contraceptives. Therefore, pregnancy or hormonal contraception may commit these women as high risk groups. The results of this study support the hypothesis that women bear a higher lung cancer risk when smoking because of female sex hormones acting as inhibitors of NNK detoxication.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Stapelfeld C,Neumann KT,Maser Edoi
10.1016/j.canlet.2017.07.016subject
Has Abstractpub_date
2017-10-01 00:00:00pages
120-126eissn
0304-3835issn
1872-7980pii
S0304-3835(17)30451-2journal_volume
405pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract：:The kinetics of total DNA adducts were compared in the liver, bladder epithelium and small intestinal epithelium of rats and mice following a single oral dose (100 mg/kg) of 3,3'-dichlorobenzidine [( 14C]DCB). Peak DNA binding (expressed as pmol DCB bound/mg DNA) in rat tissues was 153.5, 144.8 and 36.9 in the intesti...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(90)90214-i
更新日期：1990-09-01 00:00:00
abstract：:Carcinogenic studies were performed on the skin of inbred male Lister rats using 7,12-dimethylbenz[alpha]anthracene (DMBA) in low doses (2.5 mg and 5.0 mg), followed by promotion with croton oil (CO) in one half of the animals. The clinically observed tumour rate did not differ after the two carcinogen doses and was p...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(92)90160-w
更新日期：1992-08-14 00:00:00
abstract：:The acquisition and persistence of fetal microchimerism, small numbers of genetically disparate cells from the fetus in the mother, is now a well-recognized consequence of normal pregnancy. Fetal microchimerism has been associated with several classical autoimmune diseases, but its role in normal health remains undefi...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2008.07.025
更新日期：2009-04-08 00:00:00
abstract：:Activation of the BTLA-HVEM co-inhibitory signaling pathway impairs antitumor immunity. Our previous study demonstrated that the extracellular domain of murine BTLA (the soluble form of BTLA) can facilitate HSP70 vaccine-triggered antitumor immunity by blocking BTLA-HVEM interactions in a murine TC-1 non-metastatic tu...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2014.08.006
更新日期：2014-11-28 00:00:00
abstract：:The effect of ligation of the left ureter on the development of lesions in the urinary bladder were investigated in male F344 rats treated with 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) for 2 weeks followed by 0.002% N-ethyl-N-(4-hydroxybutyl)nitrosamine (EHBN) for 10 or 22 weeks. The lesions of the urinary b...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(84)90093-4
更新日期：1984-07-01 00:00:00
abstract：:Detection of novel tumor-related antigens and autoantibodies in cancer patients is expected to facilitate the diagnosis of early-stage malignant tumor and establish effective new immunotherapies. The purpose of this study was to identify novel tumor antigens in an esophageal squamous cell carcinoma (ESCC) cell line (T...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2008.01.013
更新日期：2008-05-18 00:00:00
abstract：:Artesunate (ART), a semi-synthetic derivative of artemisinin extracted from the Chinese herb Artemisia annua, is a safe and effective antimalarial drug. ART has now been analyzed for its anti-angiogenic activity in vivo and in vitro. The anti-angiogenic effect in vivo was evaluated on chicken chorioallantoic membrane ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2004.03.014
更新日期：2004-08-10 00:00:00
abstract：:Up to a 50% rate of thyroid gland tumours was induced in Sprague-Dawley rats after s.c. administration of di-isopropanolnitrosamine (DIPN). The neoplasms occurred both unilaterally and bilaterally, and were identified histologically as adenomas and adenocarcinomas of follicular epithelium origin. In a few instances, a...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(77)80022-0
更新日期：1977-03-01 00:00:00
abstract：:Nitric oxide (NO) and associated reactive nitrogen species (RNS) are involved in many physiological functions. There has been an ongoing debate to whether RNS can inhibit or perpetuate chronic inflammation and associated carcinogenesis. Although the final outcome depends on the genetic make-up of its target, the surro...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2008.03.024
更新日期：2008-09-08 00:00:00
abstract：:Lumican is a small leucine-rich proteoglycan (SLRP) of the extracellular matrix (ECM) with anti-tumor activity. We recently demonstrated that lumican inhibits the migration of melanoma cells and identified beta1 integrin as mediator of this effect [M.F. D'Onofrio, S. Brézillon, T. Baranek, C. Perreau, P.J. Roughley, F...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2009.03.032
更新日期：2009-09-28 00:00:00
abstract：:Retinoic acid alone has no effect on the human breast cancer cell line BT-20 but can amplify the antiproliferative action of interferon-gamma (IFN-gamma). In our system ornithine decarboxylase (ODC) activity correlates well with growth rate; it was investigated whether the antiproliferative effects of IFN-gamma and IF...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(89)90108-0
更新日期：1989-01-01 00:00:00
abstract：:Epithelial-to-mesenchymal transition (EMT) is the fundamental process by which an epithelial cell loses its epithelial characteristics including cell polarity and acquires mesenchymal and stemness-related features. Therefore, we investigated whether malignant pleural mesothelioma (MPMs) histologies were associated wit...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2011.01.009
更新日期：2011-03-28 00:00:00
abstract：:Myosin light-chain kinase (MLCK) plays a crucial role in the cell migration and tumor metastasis. Herein, we investigated the signaling pathways involved in MLCK using ML-7, a specific inhibitor of MLCK, in breast cancer cell proliferation and migration. Our data showed that reduction of MLCK in breast cancer cells me...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2008.05.028
更新日期：2008-11-08 00:00:00
abstract：:Hypoxia induces survival signals in hepatocellular carcinoma (HCC). We attempted to find a hypoxia-induced signal that could be used for modulating HCC cell death. Cellular retinoic acid binding protein-II (CRABP-II) expression was significantly increased in hypoxic HCC cells. Treatment with retinoic acid (RA), a liga...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2010.03.005
更新日期：2010-09-28 00:00:00
abstract：:The human multidrug resistance ABC transporters provide a protective function in our body against a large number of toxic compounds. These proteins, residing in the plasma membrane, perform an active, ATP-dependent extrusion of such xenobiotics. However, the same proteins are also used by the tumor cells to fight vari...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2005.01.061
更新日期：2006-03-08 00:00:00
abstract：:We examined the effect of alcohol consumption, cigarette smoking and flushing response on esophageal squamous cell carcinoma (ESCC) in a large-scale population-based cohort study. 44,970 middle-aged and older Japanese men were followed. A total of 215 cases of ESCC were newly diagnosed. Alcohol consumption and cigaret...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2008.10.020
更新日期：2009-03-18 00:00:00
abstract：:One of the most promising strategies to increase the efficacy of standard chemotherapy drugs is by combining them with low doses of histone deacetylases inhibitors (HDACis). Regarded as chemosensitizers, the addition of well-tolerated doses of HDACis to platinum-based chemotherapeutics has been proven in vitro and in ...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2012.09.018
更新日期：2013-02-01 00:00:00
abstract：:This aim of this study was to measure the typical free radical-induced products of DNA bases in cellular DNA of cervical cancer tissues directly irradiated by applying brachytherapy to the patients. Significant increases in the amounts of modified bases over the control level were observed in the samples isolated afte...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(98)00170-0
更新日期：1998-10-23 00:00:00
abstract：:The dynamic changes of chicken erythrocyte membranes induced by a series of N-methyl-N'-aryl-N-nitrosoureas (I X) were investigated in comparison with those of N-methyl-N-nitrosourea (MNU) and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) by electron spin resonance spectroscopy. Both I X and MNNG increased the intensity...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(85)90049-7
更新日期：1985-04-01 00:00:00
abstract：:The carcinogenic effect of ultraviolet radiation (UVR) on the skin of hairless (hr) mice was modified by two immunosuppressive agents, rabbit anti-mouse lymphocytic serum (ALS), and 6-mercaptopurine (6MP). Daily exposure of mice to UVR resulted in multiple tumor production. Carcinogenesis was measured in terms of affe...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(75)97305-x
更新日期：1976-05-01 00:00:00
abstract：:To shed light on the association of intestinal microflora with the development of colon cancer, we studied the modifying effects of intestinal microflora on the occurrence of 1,2-dimethylhydrazine (DMH)-induced colonic aberrant crypt foci (ACF) in germfree (GF), gnotobiotic (GB) and conventionalized (Cvd) rats. In the...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(97)04698-3
更新日期：1997-02-26 00:00:00
abstract：:Metastatic colonization involves paracrine/juxtacrine interactions with the microenvironment inducing an adaptive response through transcriptional regulation. However, the identities of transcription factors (TFs) induced by the metastatic microenvironment in ovarian cancer (OC) and their mechanism of action is poorly...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2017.11.012
更新日期：2018-02-01 00:00:00
abstract：:The first experimental data suggesting that neoplasm development in animals might be influenced by infectious agents were published in the early 1900s. However, conclusive evidence that DNA viruses play a role in the pathogenesis of some human cancers only emerged in the 1950s, when Epstein-Barr virus (EBV) was discov...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2006.05.010
更新日期：2007-03-18 00:00:00
abstract：:Cancer cachexia patients experience significant muscle wasting, which impairs the quality of life and treatment efficacy for patients. Skeletal muscle protein turnover is imparted by increased expression of ubiquitin-proteasome pathway components. Mitogen-activated protein kinases p38 and ERK have been shown to augmen...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2020.07.025
更新日期：2020-10-28 00:00:00
abstract：:As a continuation of studies using natural and synthetic products as cancer chemopreventive agents, we examined the reduction-oxidation potentials of hydroxylated emodin derivatives prepared from emodin in phosphate buffer at pH 7.2 using cyclic voltammetry. A significant correlation was found between the reduction po...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2005.10.043
更新日期：2006-09-28 00:00:00
abstract：:Radiotherapy (RT) is one of the most important strategies in cancer treatment. Radioresistance is a major challenge to RT and results in locoregional recurrence and metastasis. Thus, there is a great interest in investigating biomarkers to distinguish radiosensitive from radioresistant (RR) cancer patients. The develo...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2015.09.013
更新日期：2015-12-28 00:00:00
abstract：:The chimeric transcripts described in endometrial stromal sarcomas (ESS) are JAZF1/SUZ12, YWHAE/FAM22, ZC3H7/BCOR, MBTD1/CXorf67, and recombinations of PHF1 with JAZF1, EPC1, and MEAF6. The MEAF6/PHF1 fusion had hitherto been identified in only one tumor. We present two more ESS with MEAF6/PHF1 detected by transcripto...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2014.01.030
更新日期：2014-05-28 00:00:00
abstract：:To define the critical region of liver-specific tumor suppressor genes in human hepatocellular carcinoma (HCC), we analyzed 30 cases of hepatocellular carcinoma using nine 4q and six 16q microsatellite polymorphic DNA markers. We observed one major common deleted region which was flanked by D4S175-D4S1625 and there ma...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(97)00276-0
更新日期：1998-01-16 00:00:00
abstract：:The GH/IGF1 response of somatotropinomas to somatostatin analogues (SSA) is associated with their pattern of somatostatin receptor (sst1-sst5) expression. Recently, we demonstrated that expression of a truncated sst5-variant (sst5TMD4) can influence the secretory response of somatotropinomas to SSA-therapy; however, i...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2015.01.037
更新日期：2015-04-10 00:00:00
abstract：:Our aim was to identify novel tumor-associated antigens from the esophageal squamous cell carcinoma (ESCC) cell line EC0156, and related autoantibodies in sera from patients with ESCC. We used modified serological proteome analysis, involving one- and two-dimensional electrophoresis, Western blot, and MALDI-TOF/TOF-MS...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2013.10.007
更新日期：2014-03-01 00:00:00
