Abstract:
:The dynamic changes of chicken erythrocyte membranes induced by a series of N-methyl-N'-aryl-N-nitrosoureas (I X) were investigated in comparison with those of N-methyl-N-nitrosourea (MNU) and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) by electron spin resonance spectroscopy. Both I X and MNNG increased the intensity of the less mobile lipid component (h1) during the incubation while MNU decreased it. The more mobile lipid component (h2), however, was not much influenced by these agents. A positive correlation was observed between the degree of the spectral alterations (h2/h1) caused by I-X compounds and their tumorigenic potency on mouse skin with the exception of the chloride derivative (I-C1). The present results suggest that the reactions of ultimate carcinogens with cell membranes may play an important role in the tumor promoting process.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Yano K,Sonoda M,Sakagishi Ydoi
10.1016/0304-3835(85)90049-7subject
Has Abstractpub_date
1985-04-01 00:00:00pages
261-8issue
3eissn
0304-3835issn
1872-7980pii
0304-3835(85)90049-7journal_volume
26pub_type
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