Abstract:
:Effects of cis-dichlorodiammineplatinum-(II) (cis-DDP), an anticancer agent, on capping of membrane receptors were investigated in mouse spleen cells in vitro, using fluorescein labeled ligands. Cap formations of surface immunoglobulin and of concanavalin A receptors were significantly reduced by cis-DDP in relation to dose, while cell viability remained unchanged. The binding of the ligands to specific receptors was not affected by cis-DDP. The results suggested that cis-DDP inhibited cap formation by blocking membrane movement of the ligand-receptor complexes.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Tsokos GC,Choie DDdoi
10.1016/0304-3835(80)90079-8subject
Has Abstractpub_date
1980-09-01 00:00:00pages
261-7issue
3eissn
0304-3835issn
1872-7980pii
0304-3835(80)90079-8journal_volume
10pub_type
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