Systemic alterations in ornithine decarboxylase activity caused by colon cancer in mice.

abstract：:Both insulin-like growth factor II (IGF2) and H19 gene are located on chromosome 11p15.5 in close vicinity to each other, and are imprinted on different parental alleles. Although the exact mechanism remains unclear, loss of imprinting (LOI) leading to the biallelic expression of IGF2 and H19 genes has recently been r...

journal_title：Cancer letters

authors： Wu MS,Wang HP,Lin CC,Sheu JC,Shun CT,Lee WJ,Lin JT

更新日期：1997-11-25 00:00:00

abstract：:The regulator of G protein signaling 10 (RGS10) protein is a GTPase activating protein that accelerates the hydrolysis of GTP and therefore canonically inactivates G proteins, ultimately terminating signaling. Rheb is a small GTPase protein that shuttles between its GDP- and GTP-bound forms to activate mTOR. Since RGS...

journal_title：Cancer letters

authors： Altman MK,Alshamrani AA,Jia W,Nguyen HT,Fambrough JM,Tran SK,Patel MB,Hoseinzadeh P,Beedle AM,Murph MM

更新日期：2015-12-01 00:00:00

abstract：:The cancer chemotherapeutic drug, 5-(3,3-dimethyl-1-triazeno) imidazole-4-carboxamide (DIC, DTIC, NSC-45388), is metabolised in rats to a structurally related product which was detected by thin-layer chromatography. The novel metabolite has a lower mobility and a colour reaction that is indistinguishable from the pare...

journal_title：Cancer letters

authors： Kolar GF,Maurer M,Wildschütte M

更新日期：1980-09-01 00:00:00

abstract：:Cancer stem cells (CSCs) are a small subpopulation of tumor cells critical for tumor development. Their unique abilities, such as self-renewal, have resulted in tumor resistance to various cancer treatments, including traditional chemotherapy and latest immunotherapy. CSCs-targeting therapy is a promising treatment to...

journal_title：Cancer letters

authors： Shen C,Yang C,Xia B,You M

更新日期：2021-03-01 00:00:00

abstract：:Extracts of leukemic lymphocytes and leukemic myelomonocytic cells bind significantly more cAMP/mg protein than do normal cells. The binding of cAMP in leukemic cells is non-specific since the binders are unable to effectively discriminate between cAMP and cGMP in contrast to normal cells. When normal lymphocytes are ...

journal_title：Cancer letters

authors： Weber TH,Linkola J

更新日期：1980-01-01 00:00:00

abstract：:Transcripts from the murine gene family proliferin, which are increased by a wide assortment of chemical promoters of C3H10T1/2 cell morphological transformation, were shown to be induced by tri-n-butyltin chloride at concentrations above 50 nM. Two-stage transformation assays, with 3-methylcholanthrene as inducer and...

journal_title：Cancer letters

authors： Parfett CL,Pilon R

更新日期：1993-07-30 00:00:00

abstract：:Sperm protein 17 (Sp17) is a highly antigenic, testes-specific protein whose known function is to bind sperm to the zona pellucida. However, the Sp17 gene has been recently detected in normal non-testes tissues and malignant neoplasias. As the role of Sp17 in non-testes tissues is unknown, the characterization of the ...

journal_title：Cancer letters

authors： De Jong A,Buchli R,Robbins D

更新日期：2002-12-05 00:00:00

abstract：:The family of cyclin-dependent kinase complexes (Cdks) are well known for their role in the cell division cycle. What is less well known, however, is that Cdks also participate in a subset of apoptosis programs. Evidence for the role of Cdks in apoptosis comes from a variety of experimental approaches, including studi...

journal_title：Cancer letters

authors： Golsteyn RM

更新日期：2005-01-20 00:00:00

abstract：:The epidermis of the skin is a multilayered stratified epithelium whose primary function is to provide a barrier against our external environment. As a result, cells in the epidermis are subject to constant assault from environmental pathogens, many of which can cause deleterious mutations. However, most of these muta...

journal_title：Cancer letters

authors： Thieu K,Ruiz ME,Owens DM

更新日期：2013-09-10 00:00:00

abstract：:Tumor promotion potential of diacylglycerol (DAG)-rich edible oil was examined using a two-stage mouse skin carcinogenesis model initiated with 7,12-dimethylbenz[a]anthracene (DMBA). Topical treatment with 75 mg DAG oil once a day for 5 days/week for 35 weeks caused papillomas in 4 of 23 (17%) DMBA-treated female ICR ...

journal_title：Cancer letters

authors： Takasuka N,Takahashi M,Hori Y,Kitahashi T,Iigo M,Imai T,Yoshimi N,Sugimura T,Wakabayashi K

更新日期：2009-03-08 00:00:00

abstract：:Modern protocols of concomitant chemo/radiotherapy provide a very effective strategy to treat certain types of tumors. High-linear energy transfer (LET) radiations, on the other hand, have an increased efficacy against cancer with low radiosensibility and critical localization. We previously reported that oxaliplatin,...

journal_title：Cancer letters

authors： Benzina S,Altmeyer A,Malek F,Dufour P,Denis JM,Gueulette J,Bischoff P

更新日期：2008-06-08 00:00:00

abstract：:DNA methylation of the CpG-rich 5' region of the deoxycytidine kinase (dCK) gene is potentially involved in the suppression of the gene and the resistance of tumour cells to arabinosylcytosine (ara-C). 2-Chlorodeoxyadenosine (cladribine, CdA) and 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine (CAFdA) are purine nucleosi...

journal_title：Cancer letters

authors： Leegwater PA,De Abreu RA,Albertioni F

更新日期：1998-08-14 00:00:00

abstract：:Soil samples were collected from the ground under the plants of Euphorbiaceae and Thymelaeaceae known to possess Epstein-Barr virus-activating diterpene esters. In a test system, the ether extracts of such soil samples at a concentration of 20 micrograms/ml induced Epstein-Barr virus early antigen in approximately 5-2...

journal_title：Cancer letters

authors： Ito Y,Ohigashi H,Koshimizu K,Yi Z

更新日期：1983-06-01 00:00:00

abstract：:Retinoids are derivatives of vitamin A that include all trans-retinoic acid (ATRA), 13-cis-retinoic acid, (13-cis-RA), and fenretinide (4-HPR). High levels of either ATRA or 13-cis-RA can cause arrest of cell growth and morphological differentiation of human neuroblastoma cell lines, and phase I trials showed that hig...

journal_title：Cancer letters

authors： Reynolds CP,Matthay KK,Villablanca JG,Maurer BJ

更新日期：2003-07-18 00:00:00

abstract：:Although mutations of p53 and KRAS and activation of NF-κB signaling have been highly associated with chemoresistance and tumorigenesis of lung cancer, the interactive mechanisms between two of p53, KRAS, and NF-κB are elusive. In the present study, we first observed that blocking of NF-κB function in KRAS mutant A549...

journal_title：Cancer letters

authors： Yang L,Zhou Y,Li Y,Zhou J,Wu Y,Cui Y,Yang G,Hong Y

更新日期：2015-02-28 00:00:00

abstract：:Polo-like kinase 1 (PLK1) is required for multiple stages of mitosis and has been found to be overexpressed in many human malignancies. Previous studies by our group have revealed PLK1 overexpression as an independent prognostic factor for hepatocellular carcinoma (HCC). However, the underlying mechanisms of the tumor...

journal_title：Cancer letters

authors： He Z,Wu J,Dang H,Lin H,Zheng H,Zhong D

更新日期：2011-04-28 00:00:00

abstract：:We previously showed that polyphyllin D (PD) produced a stronger apoptotic effect in R-HepG2 with multi-drug resistance (MDR) than that in its parent HepG2 cells without MDR. In this study, PD was found to elicit mitochondrial fragmentation in live cells by using total internal reflection fluorescence microscopy (TIRF...

journal_title：Cancer letters

authors： Ong RC,Lei J,Lee RK,Cheung JY,Fung KP,Lin C,Ho HP,Yu B,Li M,Kong SK

更新日期：2008-03-18 00:00:00

abstract：:Dysregulation of circular RNA Foxo3 (circFoxo3) has been reported to be involved in breast cancer and non-small lung cancer progression. However, little is known about the role of circFoxo3 in prostate cancer, which the present study seeks to investigate. CircFoxo3 expression was analyzed in 22 low-grade prostate canc...

journal_title：Cancer letters

authors： Shen Z,Zhou L,Zhang C,Xu J

更新日期：2020-01-01 00:00:00

abstract：:Tumor-associated macrophages (TAMs) are important immunocytes associated with cancer metastasis. However, whether TAMs play a dominant role in mediating CXCL12/CXCR4-induced liver metastasis of colorectal cancer (CRC) remains unexplored. Herein, we found that CD206+ TAMs, which infiltrated at the invasive front, were ...

journal_title：Cancer letters

authors： Wang D,Wang X,Si M,Yang J,Sun S,Wu H,Cui S,Qu X,Yu X

更新日期：2020-04-01 00:00:00

abstract：:Stem cell factor (SCF) is a multifunctional cytokine responsible for tumorigenesis and progression. In this study, we report that increased expression of SCF in hepatocellular carcinoma (HCC) patients is highly associated with metastasis and poor prognosis. SCF inhibition with RNAi inhibited HCC cell migration, invasi...

journal_title：Cancer letters

authors： Wang X,Dong J,Jia L,Zhao T,Lang M,Li Z,Lan C,Li X,Hao J,Wang H,Qin T,Huang C,Yang S,Yu M,Ren H

更新日期：2017-05-01 00:00:00

abstract：:It is well documented that CD44 plays an important role in tumor metastasis. We investigated whether there is a correlation between the expression of its isoforms in prostate cancer cells and patient prognosis using 72 cases with biopsy specimens. Immunohistochemistry demonstrated expression of CD44H (68.1%), v6 (36.1...

journal_title：Cancer letters

authors： Takahashi S,Kimoto N,Orita S,Cui L,Sakakibara M,Shirai T

更新日期：1998-07-03 00:00:00

abstract：:It is widely known that dietary lipids can modify the ability of different cancers to grow up and metastasize, especially mammary gland tumors. However, it is still unclear whether n-6 fatty acids behave as tumor promoters in this gland cell population. The effect of different nutritional polyunsaturated fatty acids (...

journal_title：Cancer letters

authors： Muñoz SE,Lopez CB,Valentich MA,Eynard AR

更新日期：1998-04-24 00:00:00

abstract：:The immune repertoire (IR) refers to the sum of B cells and T cells with functional diversity in the circulatory system of one individual at any given time. Immune cells, which reside within microenvironments and are responsible for protecting the human body, include T cells, B cells, macrophages, and dendritic cells....

journal_title：Cancer letters

authors： Han Y,Li H,Guan Y,Huang J

更新日期：2016-09-01 00:00:00

abstract：:Three series of monoacyl-2-O-beta-D-galactosylglycerols bearing an acyl chain of varying length, from C4 to C10, were studied due to their antitumor promoting effects on the activation of the Epstein-Barr virus early antigen (EBV-EA), such activation being induced by the tumor promoter 12-O-tetradecanoylphorbol-13-ace...

journal_title：Cancer letters

authors： Colombo D,Compostella F,Ronchetti F,Scala A,Toma L,Mukainaka T,Nagatsu A,Konoshima T,Tokuda H,Nishino H

更新日期：1999-08-23 00:00:00

abstract：:High doses of folate and its quinazoline analogue with antitumour activity, N10-propargyl-5,8-dideazafolic acid (CB 3717), caused severe renal damage in mice, leading in the case of folate to death. The mouse kidneys increased in weight, which was accompanied by time- and dose-dependent induction of ornithine decarbox...

journal_title：Cancer letters

authors： Manteuffel-Cymborowska M,Chmurzyńska W,Grzelakowska-Sztabert B

更新日期：1991-09-01 00:00:00

abstract：:The widespread consumption of tea as beverage throughout the world has stimulated interest in the possibility of its use in chemoprevention of cancer. The present set of investigation was carried out to evaluate the anticarcinogenic activity of black tea using lung tumorigenesis model in Swiss albino mice. Diethylnitr...

journal_title：Cancer letters

authors： Shukla Y,Taneja P

更新日期：2002-02-25 00:00:00

abstract：:It has been nearly 9years since the FDA (Food and Drug Administration) approved the first anti-angiogenic drug (bevacizumab) for treatment of metastatic colorectal cancer. Other angiogenic inhibitors have since been approved or are in different stages of clinical trials. However, continued clinical and preclinical inv...

journal_title：Cancer letters

authors： Shojaei F

更新日期：2012-07-28 00:00:00

abstract：:NAD(P)H: quinone oxidoreductase 1 (NQO1) is an antioxidant enzyme which is associated with poor prognosis in human breast, colon, lung and liver cancers. However, the molecular mechanisms underlying the pro-tumorigenic function of NQO1 remains unclear. This study investigated the function of NQO1 in the context of hep...

journal_title：Cancer letters

authors： Li WY,Zhou HZ,Chen Y,Cai XF,Tang H,Ren JH,Wai Wong VK,Kwan Law BY,Chen Y,Cheng ST,Yu HB,Cai HY,Chen WX,Tang N,Zhang WL,Tao NN,Yang QX,Ren F,He L,Jiang H,Huang AL,Chen J

更新日期：2019-06-01 00:00:00

abstract：:To estimate the contents of flavonoids in the Danish diet, we have used a high performance liquid chromatographic method for the analysis of fruits, vegetables and beverages. The flavonoid contents were quantified, and the observations were verified by mass spectrometry. The investigation is not completed, but we are ...

journal_title：Cancer letters

authors： Justesen U,Knuthsen P,Leth T

更新日期：1997-03-19 00:00:00

abstract：:We studied the effects of a lignan, hydroxymatairesinol (HMR), and rye bran on intestinal tumor development in adenomatous polyposis colimultiple intestinal neoplasia (Apc)(Min) mice. HMR showed a strong chemopreventive effect in this animal model. The mean number of adenomas in the small intestine was significantly l...

journal_title：Cancer letters

authors： Oikannen SI,Pajari AM,Mutanen M

更新日期：2000-10-31 00:00:00