Abstract:
:Bcl-2 agonist of cell death (BAD) is a BH3-only member of the Bcl-2 family which possesses important regulatory function in apoptosis. BAD has also been shown to possess many non-apoptotic functions closely linked to cancer including regulation of glycolysis, autophagy, cell cycle progression and immune system development. Interestingly, BAD can be either pro-apoptotic or pro-survival depending on the phosphorylation state of three specific serine residues (human S75, S99 and S118). Expression of BAD and BAD phosphorylation patterns have been shown to influence tumor initiation and progression and play a predictive role in disease prognosis, drug response and chemosensitivity in various cancers. This review aims to summarize the current evidence on the functional role of BAD phosphorylation in human cancer and evaluate the potential utility of modulating BAD phosphorylation in cancer.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Bui NL,Pandey V,Zhu T,Ma L,Basappa,Lobie PEdoi
10.1016/j.canlet.2017.11.017subject
Has Abstractpub_date
2018-02-28 00:00:00pages
177-186eissn
0304-3835issn
1872-7980pii
S0304-3835(17)30739-5journal_volume
415pub_type
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