Abstract:
:C57BL/10 mice transgenic for HLA-A2 were immunized with either a full-length DNA-construct of the tumor suppressor p53 or with a minigene encoding the p53-derived immunodominant peptide p53(264)LLGRNSFEV272 (L9V). Vaccination with the full-length p53 construct induced potent cytotoxic activity of splenocytes against L9V-pulsed target cells after in vivo re-stimulation. Vaccination with the L9V-encoding minigene likewise induced specific anti-L9V cytotoxicity in vitro. Subsequent experiments revealed that peptide-pulsed dendritic cells were the most efficient cell types for in vitro re-stimulation. In concordance with this, immunization with L9V-pulsed dendritic cells also induced a potent and specific anti-L9V cytotoxic response in vitro. These data show that HLA-A2/peptide-specific cytotoxic immunity can be generated in vivo against the same immunodominant epitope by immunizing either with full-length DNA or with a DNA minigene encoding the immunodominant peptide epitope.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Petersen TR,Bregenholta S,Pedersen LO,Nissen MH,Claesson MHdoi
10.1016/s0304-3835(98)00353-xkeywords:
subject
Has Abstractpub_date
1999-04-01 00:00:00pages
183-91issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(98)00353-Xjournal_volume
137pub_type
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