Abstract:
:A tissue field of somatic genetic alterations precedes the histopathological phenotypic changes of carcinoma. Genomic changes could be of potential use in the diagnosis and prognosis of pre-invasive squamous head and neck carcinoma (HNSCC) lesions and as markers for cancer risk assessment. Studies of sequential molecular alterations and genetic progression of pre-invasive HNSCC have not been clearly defined. Studies have shown recurring alterations at chromosome 9p21 (location of the CDKN2A) and TP53 mutations in the early stages of HNSCC. However, gene silencing via hypermethylation is still a relatively new idea in the development of HNSCC and little is known about the contribution of epigenetics to the development of neoplasia, its transformation, progression, and recurrence in HNSCC. This review examines the role of promoter hypermethylation of tumor suppressor genes in the progression continuum from benign papillomas to malignancy in HNSCC.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Worsham MJ,Stephen JK,Chen KM,Havard S,Shah V,Gardner G,Schweitzer VGdoi
10.1016/j.canlet.2012.02.018subject
Has Abstractpub_date
2014-01-28 00:00:00pages
178-84issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(12)00119-Xjournal_volume
342pub_type
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