当前位置： SCI文献检索 > CANCER LETTERS期刊下所有文献 > The activation of PI 3-K and PKC zeta in PMA-induced differentiation of HL-60 cells.

The activation of PI 3-K and PKC zeta in PMA-induced differentiation of HL-60 cells.

Abstract：

:The human myelocytic leukemia cell line HL-60 is a useful model for the study of cellular differentiation. Phorbol 12-myristate 13-acetate (PMA) induces the monocyte/macrophage-like differentiation of HL-60 cells and results in growth arrest, increasing adherence. In PMA-induced differentiation of HL-60 cells, phosphoinositide 3-kinase (PI 3-K) activity was measured as phosphatidylinositol3P recovery from phosphatidylinositol by in vitro kinase assay. PI 3-K activity was increased in HL-60 cells that were stimulated by 20 nM PMA and the activity was inhibited by pretreatment with 20 microM LY294002, a specific inhibitor of PI 3-K. Members of the protein kinase C (PKC) family have been suggested to be one of the downstream targets of PI 3-K. PKC zeta is one of the atypical PKCs, non-diacylglycerol-responsive PKCs, and the activity was measured by the ability of phosphorylation onto myelin basic protein. PMA also induced the activation of PKC zeta during monocytic differentiation of HL-60 cells, and LY294002-pretreated cells failed to induce PKC zeta activation. The activity of PI 3-K is essential for PKC zeta activation, and LY294002 blocks both monocytic differentiation of HL-60 cells and activation of PKC zeta during PMA-induced cell differentiation. This implies that activated PI 3-K subsequently stimulates the PKC zeta in the process of PMA-induced monocytic differentiation.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Kim MS,Lim WK,Cha JG,An NH,Yoo SJ,Park JH,Kim HM,Lee YM

doi

10.1016/s0304-3835(01)00505-5

keywords:

subject

Has Abstract

pub_date

2001-09-28 00:00:00

pages

79-85

issue

1

eissn

0304-3835

issn

1872-7980

pii

S0304383501005055

journal_volume

171

pub_type

杂志文章

相关文献

CANCER LETTERS文献大全
  • Enhanced thermal response of a rat sarcoma by Corynebacterium parvum.

    abstract：:Corynebacterium parvum was investigated in the response of rat Mc7 sarcoma to local waterbath hyperthermia. Heat treatment of 1-1.5 cm3 foot tumors at 43 degrees C for 2 h resulted in complete regression of 71% of the tumors. The Mc7 cure was reduced to 31% when the tumors were heated at 43 degrees C for 1.5 h. C. par...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(85)90031-x

    authors： Shah SA

    更新日期：1985-03-01 00:00:00

  • Inhibition of protein kinase C by the 12-O-tetradecanoylphorbol-13-acetate antagonist glycyrrhetic acid.

    abstract：:Glycyrrhetic acid is an anti-inflammatory agent isolated from licorice root that inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-mediated tumor promotion in mouse skin. Although it has been established that glycyrrhetic acid inhibits a number of events induced by the phorbol ester tumor promoter TPA in cultured ce...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(90)90132-h

    authors： O'Brian CA,Ward NE,Vogel VG

    更新日期：1990-01-01 00:00:00

  • HDAC inhibitor SNDX-275 enhances efficacy of trastuzumab in erbB2-overexpressing breast cancer cells and exhibits potential to overcome trastuzumab resistance.

    abstract：:Trastuzumab (or Herceptin), as the first erbB2-targeted therapy, has been successfully used to treat breast cancer patients with erbB2-overexpressing tumors. However, resistances to trastuzumab frequently occur, and novel strategies/agents are urgently needed to abrogate the resistant phenotype. Our current study expl...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2011.03.019

    authors： Huang X,Wang S,Lee CK,Yang X,Liu B

    更新日期：2011-08-01 00:00:00

  • Targeting the p53-MDM2 pathway for neuroblastoma therapy: Rays of hope.

    abstract：:Despite being the subject of extensive research and clinical trials, neuroblastoma remains a major therapeutic challenge in pediatric oncology. The p53 protein is a central safeguard that protects cells against genome instability and malignant transformation. Mutated TP53 (the gene encoding p53) is implicated in many ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2020.09.023

    authors： Zafar A,Wang W,Liu G,Xian W,McKeon F,Zhou J,Zhang R

    更新日期：2021-01-01 00:00:00

  • p53 mutations are common in pancreatic cancer and are absent in chronic pancreatitis.

    abstract：:Pancreatic expression of the p53 tumor suppressor gene was studied in pancreatic adenocarcinomas and chronic pancreatitis. By immunohistochemistry, 16 of 34 (47%) cancers and none of the 24 chronic pancreatitis samples revealed nuclear staining. Sequence analysis indicated that 8 of 24 (33%) cancers were mutated for t...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(93)90168-9

    authors： Casey G,Yamanaka Y,Friess H,Kobrin MS,Lopez ME,Buchler M,Beger HG,Korc M

    更新日期：1993-05-14 00:00:00

  • Suppression of the promoter effect of polyunsaturated fatty acids by the absence of dietary vitamin E in experimental mammary carcinoma.

    abstract：:Because lipoperoxides seem able to modulate tumor growth, we have examined the concomitant effects of dietary antioxidant (vitamin E) and of a high amount of polyunsaturated fatty acids (PUFA) in a model of chemically-induced mammary carcinogenesis. Two groups of rats received a high fat diet with or without added vit...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(97)04671-5

    authors： Lhuillery C,Cognault S,Germain E,Jourdan ML,Bougnoux P

    更新日期：1997-03-19 00:00:00

  • RNA helicase YTHDC2 promotes cancer metastasis via the enhancement of the efficiency by which HIF-1α mRNA is translated.

    abstract：:YTH domain containing 2 (YTHDC2) is a member of the DExD/H-box family of ATP-dependent RNA helicases. We previously found that YTHDC2 expression is up-regulated in several human cancer cells. In this study, we demonstrate novel roles for YTHDC2 in metastasis of colon tumor cells via translation-dependent pathway. Knoc...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2016.02.022

    authors： Tanabe A,Tanikawa K,Tsunetomi M,Takai K,Ikeda H,Konno J,Torigoe T,Maeda H,Kutomi G,Okita K,Mori M,Sahara H

    更新日期：2016-06-28 00:00:00

  • Soluble and membrane-bound catechol-O-methyltransferase in normal and malignant mammary gland.

    abstract：:The levels of 26 kDa-soluble (S) and 30 kDa-membrane-bound (MB) catechol-O-methyltransferase (COMT) polypeptides were determined in paired samples from normal and neoplastic breast tissue of 32 patients with breast cancer. Immunohistochemical staining showed that the COMT reaction in normal mammary tissue was restrict...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(99)00197-4

    authors： Tenhunen J,Heikkilä P,Alanko A,Heinonen E,Akkila J,Ulmanen I

    更新日期：1999-09-20 00:00:00

  • Effects of methotrexate on folates in Krebs ascites and L1210 murine leukemia cells.

    abstract：:Changes in reduced folates upon exposure of Krebs ascites cells and L1210 murine leukemia cells to methotrexate (MTX) have been measured by stoichiometric entrapment of tissue methylenetetrahydrofolate into a stable ternary complex with thymidylate synthase and tritiated 5-fluoro-2'-deoxy-uridine-5'-monophosphate. Tet...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(86)90132-1

    authors： Kesavan V,Sur P,Doig MT,Scanlon KJ,Priest DG

    更新日期：1986-01-01 00:00:00

  • Endothelin-1 promotes cell survival in renal cell carcinoma through the ET(A) receptor.

    abstract：:Endothelin-1 (ET-1) is a potent vasoconstrictor that has been shown to significantly impact many benign and malignant tissues by signaling through its two cognate receptors: ET(A) and ET(B). As ET-1 has a role in both normal and diseased kidney, we initiated studies to investigate endothelin axis expression and functi...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2006.02.007

    authors： Pflug BR,Zheng H,Udan MS,D'Antonio JM,Marshall FF,Brooks JD,Nelson JB

    更新日期：2007-02-08 00:00:00

  • Modulation of aflatoxin B1 activated protein kinase C by phenolic compounds.

    abstract：:Several natural phenolic compounds were tested in vitro for their effect on the activity of protein kinase C isolated from liver cytosol, particulate and nuclear fractions of normal and aflatoxin B1 treated rats. Quercetin and kaempferol inhibited the enzyme activity of all these fractions at very low dose levels. The...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(97)00337-6

    authors： Mistry KJ,Krishna M,Bhattacharya RK

    更新日期：1997-12-16 00:00:00

  • Hepatocyte growth factor (HGF) upregulates heparanase expression via the PI3K/Akt/NF-κB signaling pathway for gastric cancer metastasis.

    abstract：:Heparanase (HPA) is an endoglucuronidase that can promote the shedding of associated cytokines in several types of tumors. However, little is known about what controls the expression of HPA or its role in gastric cancer. In this study, we report for the first time that HGF regulates HPA expression to promote gastric c...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2015.02.043

    authors： Hao NB,Tang B,Wang GZ,Xie R,Hu CJ,Wang SM,Wu YY,Liu E,Xie X,Yang SM

    更新日期：2015-05-28 00:00:00

  • ARID1A deficiency and immune checkpoint blockade therapy: From mechanisms to clinical application.

    abstract：:The AT-rich interaction domain 1A (ARID1A, also known as BAF250a) is a chromatin remodeling gene, which frequently mutates across a broad spectrum of cancers with loss expression of the ARID1A protein. Recently, the association between ARID1A deficiency and immune checkpoint blockade (ICB) therapy has been reported. A...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2020.01.001

    authors： Hu G,Tu W,Yang L,Peng G,Yang L

    更新日期：2020-03-31 00:00:00

  • Mesenchymal stem cells in lung cancer tumor microenvironment: their biological properties, influence on tumor growth and therapeutic implications.

    abstract：:The tumor microenvironment (TME) of lung cancer has been documented to play an important role in participating in tumor disease progression. As the precursor of most stroma in TME, mesenchymal stem cells (MSCs) draw great attention since evidence has suggested that MSCs derived from lung cancer patients present a diff...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2014.07.047

    authors： Liu R,Wei S,Chen J,Xu S

    更新日期：2014-10-28 00:00:00

  • Alterations in repair of alkylating agent-induced DNA damage in polyamine-depleted human cells.

    abstract：:Treatment of HeLa cells with the polyamine biosynthesis inhibitors difluoromethylornithine (DFMO) and/or methylglyoxal bis(guanylhydrazone) (MGBG) results in marked depression in levels of the cellular polyamines putrescine, spermidine and spermine. Cells in this polyamine-depleted state exhibited increased sensitivit...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(93)90015-2

    authors： Snyder RD,Bhatt S

    更新日期：1993-08-16 00:00:00

  • Reduction of circular RNA Foxo3 promotes prostate cancer progression and chemoresistance to docetaxel.

    abstract：:Dysregulation of circular RNA Foxo3 (circFoxo3) has been reported to be involved in breast cancer and non-small lung cancer progression. However, little is known about the role of circFoxo3 in prostate cancer, which the present study seeks to investigate. CircFoxo3 expression was analyzed in 22 low-grade prostate canc...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2019.10.006

    authors： Shen Z,Zhou L,Zhang C,Xu J

    更新日期：2020-01-01 00:00:00

  • Cucurbitacin B potently suppresses non-small-cell lung cancer growth: identification of intracellular thiols as critical targets.

    abstract：:Cucurbitacin B (CuB), has recently emerged as a potent anticancer agent; however, its efficacy in non-small-cell lung cancer (NSCLC) and the mechanism(s) initiating its biological effects remain largely unclear. In this study, CuB potently suppressed the growth of four NSCLC cells (H1299, A549, HCC-827 and H661) in vi...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2013.01.008

    authors： Kausar H,Munagala R,Bansal SS,Aqil F,Vadhanam MV,Gupta RC

    更新日期：2013-05-10 00:00:00

  • Hypoxia-inducible factors in OSCC.

    abstract：:Oral squamous cell carcinoma (OSCC) is a characteristic locally aggressive tumor in which hypoxia levels are very high, causing a low response to chemotherapy and providing basic resistance to anticancer drugs. Tumoral hypoxia directly depends on hypoxia-inducible factors (HIF). The goal of this paper is to describe H...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2011.08.017

    authors： Pérez-Sayáns M,Suárez-Peñaranda JM,Pilar GD,Barros-Angueira F,Gándara-Rey JM,García-García A

    更新日期：2011-12-26 00:00:00

  • Immunization with liposome-anchored pegylated peptides modulates doxorubicin sensitivity in P-glycoprotein-expressing P388 cells.

    abstract：:The clinical use of chemotherapy in cancer treatment is limited by the occurrence of multidrug resistance (MDR) associated with the overexpression of membrane transporters, one of the best known is P-glycoprotein (Pgp), that actively expels drugs out of tumor cells. To overcome Pgp-mediated MDR, synthetic peptides cor...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2007.04.001

    authors： Gatouillat G,Odot J,Balasse E,Nicolau C,Tosi PF,Hickman DT,López-Deber MP,Madoulet C

    更新日期：2007-11-18 00:00:00

  • IL-6 induced M1 type macrophage polarization increases radiosensitivity in HPV positive head and neck cancer.

    abstract：:Radiation is a crucial component of head and neck squamous cell carcinoma (HNSC) treatment. Human papillomavirus-positive (HPV+) HNSC is significantly more radiosensitive than HPV- HNSC, but the mechanism underlying this increased sensitivity is unknown. We investigated the possible involvement of macrophage subpopula...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2019.04.032

    authors： Chen X,Fu E,Lou H,Mao X,Yan B,Tong F,Sun J,Wei L

    更新日期：2019-08-01 00:00:00

  • Radiomics model of magnetic resonance imaging for predicting pathological grading and lymph node metastases of extrahepatic cholangiocarcinoma.

    abstract：:The aim of this study was to evaluate diagnostic performance of radiomics models of MRI in the detection of differentiation degree (DD) and lymph node metastases (LNM) of extrahepatic cholangiocarcinoma (ECC). We retrospectively enrolled 100 patients with ECC confirmed by pathology from January 2011 to December 2018. ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2019.11.036

    authors： Yang C,Huang M,Li S,Chen J,Yang Y,Qin N,Huang D,Shu J

    更新日期：2020-02-01 00:00:00

  • Modification of PM2 DNA with N-acetoxy-2-acetylaminofluorene: changes in buoyant density, electrophoretic mobility and electron microscopic structure.

    abstract：:PM2 DNA, forms I and II, were chemically modified with the ultimate carcinogen N-acetoxy-2-acetylaminofluorene. The products were subjected to 3 analytical procedures: (i) buoyant density centrifugation in the presence of the intercalating dyes ethidium bromide or propidium diiodide; (ii) agarose gel electrophoresis: ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(80)90151-2

    authors： Thielmann HW,Kuhn C

    更新日期：1980-02-01 00:00:00

  • Polo-like kinase 1 contributes to the tumorigenicity of BEL-7402 hepatoma cells via regulation of Survivin expression.

    abstract：:Polo-like kinase 1 (PLK1) is required for multiple stages of mitosis and has been found to be overexpressed in many human malignancies. Previous studies by our group have revealed PLK1 overexpression as an independent prognostic factor for hepatocellular carcinoma (HCC). However, the underlying mechanisms of the tumor...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2011.01.007

    authors： He Z,Wu J,Dang H,Lin H,Zheng H,Zhong D

    更新日期：2011-04-28 00:00:00

  • Neutrophil gelatinase-associated lipocalin (NGAL) in human neoplasias: a new protein enters the scene.

    abstract：:The small 25 kDa peptide, neutrophil gelatinase-associated lipocalin (NGAL), first known as an antibacterial factor of natural immunity, and an acute phase protein, is currently one of the most interesting and enigmatic proteins involved in the process of tumor development. The aim of the present review is to point ou...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2009.05.027

    authors： Bolignano D,Donato V,Lacquaniti A,Fazio MR,Bono C,Coppolino G,Buemi M

    更新日期：2010-02-01 00:00:00

  • Synergistic anticancer activity of triptolide combined with cisplatin enhances apoptosis in gastric cancer in vitro and in vivo.

    abstract：:Cisplatin is an anticancer agent that is effective against several types of cancer, including gastric cancer. However, its therapeutic application is limited by its toxicity in normal tissues and complications caused in patients. In this study, we attempted to clarify how triptolide, an active component extracted from...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2012.01.006

    authors： Li CJ,Chu CY,Huang LH,Wang MH,Sheu LF,Yeh JI,Hsu HY

    更新日期：2012-06-28 00:00:00

  • NRF2 antioxidant response protects against acidic bile salts-induced oxidative stress and DNA damage in esophageal cells.

    abstract：:Gastroesophageal reflux disease (GERD) is the main risk factor for Barrett's tumorigenesis. In this study, we investigated the role of NRF2 in response to exposure to acidic bile salts (ABS), in conditions that mimic GERD, using Barrett's esophagus cell models. We detected an increase in NRF2 protein levels, following...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2019.05.031

    authors： Peng D,Lu H,Zhu S,Zhou Z,Hu T,Chen Z,Zaika A,El-Rifai W

    更新日期：2019-08-28 00:00:00

  • IFITM1 suppression blocks proliferation and invasion of aromatase inhibitor-resistant breast cancer in vivo by JAK/STAT-mediated induction of p21.

    abstract：:Interferon induced transmembrane protein 1 (IFITM1) belongs to a family of interferon stimulated genes (ISGs) that is associated with tumor progression and DNA damage resistance; however, its role in endocrine resistance is not known. Here, we correlate IFITM1 expression with clinical stage and poor response to endocr...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2017.04.005

    authors： Lui AJ,Geanes ES,Ogony J,Behbod F,Marquess J,Valdez K,Jewell W,Tawfik O,Lewis-Wambi J

    更新日期：2017-07-28 00:00:00

  • Triptolide simultaneously induces reactive oxygen species, inhibits NF-kappaB activity and sensitizes 5-fluorouracil in colorectal cancer cell lines.

    abstract：:The in vitro chemosensitizing effect of triptolide (PG490) on the cytotoxicity of 5-fluorouracil (5-FU) was determined in three colorectal cancer (CRC) cell lines. PG490 alone was toxic to CRC cell lines (IC(50)s: 1.39-5.51nM). The cytotoxicity of 5-FU to CRC cell lines was 4-15-fold sensitized by combining use of low...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2009.10.013

    authors： Xu B,Guo X,Mathew S,Armesilla AL,Cassidy J,Darling JL,Wang W

    更新日期：2010-05-28 00:00:00

  • p38 MAP kinase controls EGF receptor downregulation via phosphorylation at Ser1046/1047.

    abstract：:The desensitization mechanism of the EGF receptor (EGFR) is important for the regulation of cancer cells. Although the phosphorylation of EGFR at Tyr1045 and Ser1046/1047 (Ser1046/7) reportedly accounts for such desensitization, the precise mechanism still remains unknown. Therefore, the present study investigated the...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2008.11.034

    authors： Adachi S,Natsume H,Yamauchi J,Matsushima-Nishiwaki R,Joe AK,Moriwaki H,Kozawa O

    更新日期：2009-05-08 00:00:00

  • Modulation of cellular phosphoprotein profiles in transformation and redifferentiation of murine AKR embryonic fibroblastic cells.

    abstract：:Cellular phosphoprotein profiles from normal mouse embryonic fibroblast AKR-2B cells were compared to those of their permanently, chemically transformed malignant counterparts AKR-MCA cells, and AKR-2B cells reversibly transformed by transforming growth factor (AKR-TGF). Similar 32P-phosphorylation profiles were obser...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(85)90153-3

    authors： Chakrabarty S,Brattain MG

    更新日期：1985-11-01 00:00:00