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Mesenchymal stem cells in lung cancer tumor microenvironment: their biological properties, influence on tumor growth and therapeutic implications.

Abstract：

:The tumor microenvironment (TME) of lung cancer has been documented to play an important role in participating in tumor disease progression. As the precursor of most stroma in TME, mesenchymal stem cells (MSCs) draw great attention since evidence has suggested that MSCs derived from lung cancer patients present a different phenotype compared to their normal counterparts. Furthermore, MSCs could be recruited towards tumor sites and influence tumor survival, although the effect remains contradictory. Our review will summarize the current advance of the role MSCs in lung cancer and explore the possible treatment strategies by blocking their crosstalk.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Liu R,Wei S,Chen J,Xu S

doi

10.1016/j.canlet.2014.07.047

subject

Has Abstract

pub_date

2014-10-28 00:00:00

pages

145-52

issue

2

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(14)00426-1

journal_volume

353

pub_type

杂志文章,评审

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