Abstract:
:Pancreatic adenocarcinoma (PDAC) is associated with poor clinical outcomes and incomplete responses to conventional therapy. Therefore, there is an unmet clinical need to better understand the predisposing factors for pancreatic cancer in hopes of providing early screening to high-risk patients. While select risk factors such as age, race, and family history, or predisposing syndromes are unavoidable, there are several new and established risk factors that allow for intervention, namely by counseling patients to make the appropriate lifestyle modifications. Here, we discuss the best-studied risk factors for PDAC such as tobacco use and chronic pancreatitis, as well as newly emerging risk factors including select nutritional deficits, bacterial infections, and psychosocial factors. As several of these risk factors appear to be additive or synergistic, by understanding their relationships and offering coordinated, multidisciplinary care to high-risk patients, it may be possible to reduce pancreatic cancer incidence and improve clinical outcomes through early detection.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Principe DR,Rana Adoi
10.1016/j.canlet.2020.04.022subject
Has Abstractpub_date
2020-08-10 00:00:00pages
56-65eissn
0304-3835issn
1872-7980pii
S0304-3835(20)30216-0journal_volume
485pub_type
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