Abstract:
:Inhibition of angiogenesis provides a potential anti-cancer therapy. Here we describe a novel recombinant peptide composed of active fragments of two distinct angiogenesis inhibitors, platelet factor-4 (C-13 fragment) and vasostatin (N-terminal amino acids 135-164) with a nonpolar peptide bridge of Gly-Pro-Gly. This fusion peptide showed significantly enhanced efficacy compared with its parent peptides in inhibiting human endothelial cell proliferation and neovasculerization in chick embryo chorioallantoic membrane. The data suggest that making a single recombinant peptide containing the active fragments of multiple angiogenesis inhibitors is a promising approach to developing a better anti-angiogenetic therapy.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Li X,Jiang L,Wang Y,Xiao Y,Huang Y,Yao Q,Yang Y,Wu Xdoi
10.1016/j.canlet.2007.05.002subject
Has Abstractpub_date
2007-10-18 00:00:00pages
29-32issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(07)00231-5journal_volume
256pub_type
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