Abstract:
:Binding of 1-nitro[14C]pyrene (1-NP) or its metabolites to cellular DNA and protein in cultures of rabbit alveolar macrophages and lung and tracheal tissues was examined. DNA binding was highest in tracheal tissue (136.9 +/- 18.3 pmol 1-NP/mg DNA). DNA binding in macrophages and lung tissue was one-fifth of the level observed in tracheal tissue. Also, 1-NP was bound to cellular protein in tracheal and lung tissues, and at a lower level in macrophages. Co-cultivation of the macrophages with lung and tracheal tissues decreased the DNA binding in tracheal tissue and increased the protein binding in macrophages. This study shows that lung cells and tissue are capable of binding 1-NP or its metabolites to DNA and protein.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
King LC,Jackson M,Ball LM,Lewtas Jdoi
10.1016/0304-3835(83)90091-5subject
Has Abstractpub_date
1983-07-01 00:00:00pages
241-6issue
3eissn
0304-3835issn
1872-7980pii
0304-3835(83)90091-5journal_volume
19pub_type
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