Abstract:
:The objective of this work was to investigate the expression of glutathione S-transferase placental form (GST-P) in 9,10-dimethyl-1,2-benzanthracene (DMBA)-induced hamster buccal pouch carcinogenesis. Lesions were classified histopathologically into four categories, simple hyperplasia, papillary and nodular (PN) hyperplasia, papilloma and squamous cell carcinoma (SCC). Respective mean percentage GST-P positive areas were 81.6 +/- 7.3%, 76.1 +/- 7.3%, 25.8 +/- 4.9% and 1.9 +/- 1.2%, with significant (P < 0.001) differences confirmed between each of the lesions. These results indicate that GST-P is a useful positive marker for neoplastic lesions and that a decreased expression occurs with progression so that it may be predictive of future development of malignancy.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Iida K,Yamamoto M,Kato M,Yoshida K,Kurita K,Tatematsu Mdoi
10.1016/s0304-3835(98)00286-9keywords:
subject
Has Abstractpub_date
1999-01-29 00:00:00pages
129-36issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(98)00286-9journal_volume
135pub_type
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