Abstract:
:Oncoprotein Myc, hetero-dimerized with Max through a b/HLH/Zip region, is a transcription factor that governs important cellular processes such as cell cycle entry, proliferation and differentiation. We found that linoleic acid, isolated from Pollen Typhae, and other unsaturated fatty acids have strong inhibitory effects on the binding of Myc-Max heterodimer to an E-box DNA site (CA(C/T)GTG). The interaction of a fatty acid with a protein dimer, not with DNA, is assumed to block the entire Myc-Max-DNA complex formation. Unsaturated fatty acids also showed cytotoxicity against a SNU16 human stomach cancer cell line and conjugated linoleic acid suppressed mRNA expression of several myc-target genes; ornithine decarboxylase, p53, cdc25a in the SNU16 cells.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Chung S,Park S,Yang CHdoi
10.1016/s0304-3835(02)00455-xkeywords:
subject
Has Abstractpub_date
2002-12-15 00:00:00pages
153-62issue
1-2eissn
0304-3835issn
1872-7980pii
S030438350200455Xjournal_volume
188pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract::During the late period of pregnancy (on the 50th and 53rd days post coitum) 2 dogs were injected intraperitoneally with 100 mg/kg (a single administration) of nitrosoethylurea. Nine puppies were born. During the 9 year period of observation no tumours were detected in mother-dogs. Three of 9 offspring developed the fo...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(81)90052-5
更新日期:1981-03-01 00:00:00
abstract::We constructed the plasmid which can express human wild-type p53 cDNA and introduced it into the human osteosarcoma cell line SAOS-2 that lacks the chromosomal p53 gene. A cell clone stably expressing p53 protein was isolated and UV sensitivity and UV-induced mutation frequencies of the clone were examined. The UV sen...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(97)00406-0
更新日期:1998-01-16 00:00:00
abstract::The effect of ligation of the left ureter on the development of lesions in the urinary bladder were investigated in male F344 rats treated with 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) for 2 weeks followed by 0.002% N-ethyl-N-(4-hydroxybutyl)nitrosamine (EHBN) for 10 or 22 weeks. The lesions of the urinary b...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(84)90093-4
更新日期:1984-07-01 00:00:00
abstract::In previous National Toxicology Program (NTP) studies, rotenone reduced the background incidence of hepatocellular carcinoma in male B6C3F1 mice. In the present studies, rotenone reduced the basal hepatic labeling index of male B6C3F1 mice in a dose-dependent fashion and inhibited hepatocellular proliferation, but not...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(95)03869-x
更新日期:1995-08-16 00:00:00
abstract::Iron-enriched diets caused an increase of tumor rate in two models of dimethylhydrazine(DMH)-induced colon tumorigenesis in mice. The effect was independent of the time the iron-diet was fed, i.e. during DMH-treatment or following the DMH-treatment period. The increase of tumor rate depended on the iron concentration ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(92)90239-r
更新日期:1992-08-31 00:00:00
abstract::In view of the controversy that exists regarding the histamine content and diamine oxidase activity in relation to human carcinomatous growths, the present investigation was undertaken and carcinomatous tissues of skin, breast and rectum were analysed. The result of the experiment gives a clear evidence that both hist...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(87)90012-7
更新日期:1987-02-01 00:00:00
abstract::The ability of a cancer cell to metastasis to a distant site is partly dependent on the secretion of matrix degrading enzymes. The lysosomal cysteine proteinases, cathepsins B and L, have been shown to be secreted by a number of cancer cells and have been implicated in metastasis. Cathepsins B and L are regulated by a...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(02)00275-6
更新日期:2002-11-28 00:00:00
abstract::Breast cancer cells in their virulent undifferentiated state are characterized by lack of functional estrogen receptors (ER) and/or progesterone receptors (PR) as well as relatively low levels of other normal differentiation markers such as milk proteins and lipid droplets. To date, no method for in situ elevation of ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(03)00146-0
更新日期:2003-05-08 00:00:00
abstract::Radiation is a crucial component of head and neck squamous cell carcinoma (HNSC) treatment. Human papillomavirus-positive (HPV+) HNSC is significantly more radiosensitive than HPV- HNSC, but the mechanism underlying this increased sensitivity is unknown. We investigated the possible involvement of macrophage subpopula...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2019.04.032
更新日期:2019-08-01 00:00:00
abstract::In the present study, the question of whether the ubiquitous environmental pollutant, 1-nitropyrene (1-NP), can induce gamma-glutamyltranspeptidase (GGT)-positive foci, an early lesion occurring during hepatocarcinogenesis, when given orally to F344 rats was examined. Significant induction of GGT-positive foci was obs...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(89)90031-1
更新日期:1989-04-01 00:00:00
abstract::Pancreatic cancer is one of the most aggressive malignancies and has been considered poorly immunogenic for decades. However, this characterization might be over-simplistic. A more sophisticated approach is needed in order to develop new treatment strategies. In this review, we will focus on T cell exhaustion as a phe...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2016.02.057
更新日期:2016-10-10 00:00:00
abstract::CD133 is a surface marker of liver cancer stem cells. Transmembrane 4 L six family member 5 (TM4SF5) promotes sphere growth and circulation. However, it is unknown how CD133 and TM4SF5 cross-talk with each other for cancer stem cell properties. Here, we investigated the significance of inter-relationships between CD13...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2018.09.009
更新日期:2018-12-01 00:00:00
abstract::Hepatocyte nodules and hepatocellular carcinomas were induced in male Fischer rats using the resistant hepatocyte model. The immunoreactive cytosolic levels of the heme-binding Z protein (HBP) were reduced by 56% (P less than 0.001; 2-tailed t-test) in early hepatocyte nodules (25 weeks) and hepatocellular carcinomas ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(88)90213-3
更新日期:1988-12-01 00:00:00
abstract::We detected aberrant Midkine (MK) expressions in human insulinoma and pancreatic cancer tissues by immunohistochemistry, revealing its potential role in tumorigenesis/carcinogenesis. With a nested-touchdown PCR program we were able to detect the tMK in all human tumor/cancer tissues and cancer/tumor cell lines. Detect...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2007.01.019
更新日期:2007-08-08 00:00:00
abstract::D-Tryptophan-6-luteinizing hormone-releasing hormone (D-Trp6-LH-RH) applied from day -8 to day +15 before and after administration of the nitrosourea analog, N,N'-bis[N-(2-chloroethyl)-N-nitrosocarbamoyl]cysteamine (CNCC), favored bone marrow restoration, as independently evaluated by 3 observers in a double-blind fas...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(84)80036-1
更新日期:1984-12-01 00:00:00
abstract::Effects of the green tea catechins (GTCs) on the late promotion or progression stage of mammary gland carcinogenesis were examined in female Sprague-Dawley (SD) rats pretreated with 7,12-dimethylbenz(a)anthracene (DMBA). A total of 84 7-week-old rats received a 50 mg/kg body weight intra-gastric dose of DMBA, and star...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(96)04560-0
更新日期:1997-01-30 00:00:00
abstract::Semi-permeable magnetic microcapsules containing polyethyleneimine (PEI) have been developed as retrievable carcinogen traps. In vitro, the soluble core PEI and membrane both bound reactive substances of limited aqueous stability, such as from [14C]N-methyl-N-nitrosourea ([14C]NMU), and aqueous stable dyes of molecula...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(87)90101-7
更新日期:1987-07-01 00:00:00
abstract::The sex-determining region Y-box 7 (Sox7) is a member of high mobility group (HMG) transcription factor family, essential for embryonic development and endoderm differentiation. Deregulation of Wnt signaling pathway is a hallmark of colorectal cancer. Our results showed that the expression level of SOX7 was frequently...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2008.11.014
更新日期:2009-05-08 00:00:00
abstract::We have previously shown that transforming growth factor (TGF)-beta up-regulates matrix metalloproteinase (MMP)-2 leading to the induction of oncogenic signaling in preneoplastic MCF10A human breast epithelial cells. The present study investigated the mechanism of transcriptional regulation of MMP-2 by TGF-beta in MCF...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2006.12.016
更新日期:2007-07-08 00:00:00
abstract::The regulation of MYC-regulated long non-coding RNAs has been reported to contribute to certain types of cancers. However, the role of MYC-induced long non-coding RNA (MINCR) in the tumorigenesis of gallbladder cancer (GBC) is still largely unknown. In this study, we discovered that MINCR was markedly upregulated in G...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.06.019
更新日期:2016-09-28 00:00:00
abstract::Prolonged exposure to elevated levels of estrogen is a risk factor for breast cancer. Though increased cell growth and loss of DNA repair capacity is one of the proposed mechanisms for estrogen-induced cancers, the mechanism through which estrogen induces cell growth and decreases DNA repair capacity is not clear. DNA...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2011.10.022
更新日期:2012-03-01 00:00:00
abstract::Serial determinations of urinary biopterin were performed in rats during the development of lung tumors induced by radon inhalation and 5,6-benzonaphtoflavone administration. A striking increase in biopterin levels was observed in animals which developed single or multiple epidermoid carcinoma of the lung and this inc...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(90)90091-b
更新日期:1990-10-08 00:00:00
abstract::Caffeine may very well be the most frequently ingested neuroactive drug in the world. Mechanistically, caffeine has been reported to affect cell cycle function, induce programmed cell death or apoptosis and perturb key cell cycle regulatory proteins. Although the effects of caffeine have been heavily investigated, muc...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2006.03.032
更新日期:2007-03-08 00:00:00
abstract::Angiotensin II (Ang II) has been implicated in muscle protein loss in cachexia. To determine whether the Ang I/II system directly inhibits protein synthesis in muscle their effect has been monitored in vitro using murine myotubes as a surrogate model system. Ang I inhibited protein synthesis by 40-50% over the concent...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2005.02.007
更新日期:2006-01-18 00:00:00
abstract::Mutations in oncogenes and tumor suppressor genes confer a fitness advantage to cells that can lead to cancer. The tumor phenotype normally results from the interaction of many mutant genes making it difficult to estimate the fitness advantage provided by any oncogene, except when tumors depend on one oncogene only. W...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2010.01.020
更新日期:2010-08-01 00:00:00
abstract::We investigated the molecular mechanisms responsible for fisetin-induced apoptosis in U266 cells. Fisetin elicited the cytotoxicity in U266 cells, manifested as an increased fraction of the cells with sub-G1 content or stained positively with TUNEL labeling. Fisetin enhanced caspase-3 activation, downregulation of Bcl...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2012.01.008
更新日期:2012-06-28 00:00:00
abstract::Patients with pancreatic adenocarcinoma (PDAC) have a 5-year survival rate of 8%, the lowest of any cancer in the United States. Traditional chemotherapeutic regimens, such as gemcitabine- and fluorouracil-based regimens, often only prolong survival by months. Effective precision targeted therapy is therefore urgently...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2020.08.002
更新日期:2020-10-28 00:00:00
abstract::Emerging evidence indicates that cancer stem cells (CSCs) are involved in tumorigenesis, tumor recurrence, and therapeutic resistance in hepatocellular carcinoma (HCC). However, the mechanisms underlying HCC CSC regulation remain largely unknown. Here we report our analysis of 97 paraffin-embedded HCC tumor specimens....
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2019.02.040
更新日期:2019-05-28 00:00:00
abstract::To minimize adverse side effects of chemotherapy, we have developed a micellar drug carrier that retains hydrophobic drugs, and then releases the drug by ultrasonic stimulation. This study investigated the DNA damage induced by doxorubicin (DOX) delivered to human leukemia (HL-60) cells from pluronic P-105 micelles wi...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(00)00399-2
更新日期:2000-06-30 00:00:00
abstract::In this study we combined flow cytometry with fluorescence in situ hybridization to detect numerical aberrations in chromosomes. Fifty-nine human malignant gliomas were examined by flow cytometry for DNA-content and cell cycle analysis and for numerical aberrations of chromosome 1 by in situ hybridization using a chro...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(98)00383-8
更新日期:1999-04-26 00:00:00