Abstract:
:We detected aberrant Midkine (MK) expressions in human insulinoma and pancreatic cancer tissues by immunohistochemistry, revealing its potential role in tumorigenesis/carcinogenesis. With a nested-touchdown PCR program we were able to detect the tMK in all human tumor/cancer tissues and cancer/tumor cell lines. Detection of MK in the peripheral cells and precancerous lesions implies its potential for early cancer/tumor diagnosis. Furthermore, we have discovered two novel truncations of the MK, tMKB and tMKC, respectively, in the disease specimens. Our data not only provide an efficient methodology potentially for clinical application but also shed light on the molecular mechanism underlying the role for MK in tumorigenesis/carcinogenesis.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Tao P,Xu D,Lin S,Ouyang GL,Chang Y,Chen Q,Yuan Y,Zhuo X,Luo Q,Li J,Li B,Ruan L,Li Q,Li Zdoi
10.1016/j.canlet.2007.01.019subject
Has Abstractpub_date
2007-08-08 00:00:00pages
60-7issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(07)00033-Xjournal_volume
253pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract::To identify non-tumor biomarkers for prediction of tumor HPV status and prognosis of patients with squamous cell carcinoma of the oropharynx (SCCOP), we evaluated the association of single nucleotide polymorphisms (SNPs) in pre-miRNAs with HPV16 status and survival for SCCOP patients. We analyzed HPV16 status in tumor...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2012.11.048
更新日期:2013-04-28 00:00:00
abstract::Glycyrrhetic acid is an anti-inflammatory agent isolated from licorice root that inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-mediated tumor promotion in mouse skin. Although it has been established that glycyrrhetic acid inhibits a number of events induced by the phorbol ester tumor promoter TPA in cultured ce...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(90)90132-h
更新日期:1990-01-01 00:00:00
abstract::The mixed lineage kinase domain-like protein (MLKL) has emerged as a critical mediator of necroptosis, which results in the release of cellular damage-associated molecular patterns (DAMPs). However, its physiological role in regulating inflammation is not fully understood. We herein showed that Mlkl-/- mice were highl...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2019.05.034
更新日期:2019-09-10 00:00:00
abstract:OBJECTIVE:The bad prognosis of primary carcinoma of the Fallopian tube is ascribed to early lymphogenous metastasis. Due to the rarity of cases, there exist only few and divergent results on the importance of lymph node metastasis in the relevant literature. Thus, our study aimed at detecting the incidence of lymph nod...
journal_title:Cancer letters
pub_type: 杂志文章,多中心研究
doi:10.1016/s0304-3835(99)00273-6
更新日期:1999-12-01 00:00:00
abstract::Application of a single high dose of 7,12-dimethylbenz[a]anthracene (DMBA, 1 mg) or N-nitrosomethylurea (NMU, 0.4 mg) to the ears of either athymic nu/nu or phenotypically normal nu/+ mice (BALB/c background) resulted in the appearance of cutaneous sebaceous adenomas as well as squamous cell tumors, both at the site o...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(86)90069-8
更新日期:1986-12-01 00:00:00
abstract::The human multidrug resistance ABC transporters provide a protective function in our body against a large number of toxic compounds. These proteins, residing in the plasma membrane, perform an active, ATP-dependent extrusion of such xenobiotics. However, the same proteins are also used by the tumor cells to fight vari...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2005.01.061
更新日期:2006-03-08 00:00:00
abstract::Sulofenur treatment (12.5 microM-1 mM) of colon adenocarcinoma cell lines resulted in dose- and time-dependent cell killing. LYc5 cells were viable longer than GC3/c1 cells. Each concentration resulted in elevation of cytosolic calcium [Ca2+]i) for both cell lines. At lower doses, elevation was delayed for LYc5 cells....
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(94)03607-k
更新日期:1995-01-06 00:00:00
abstract::We have investigated the structure of the carbohydrate moiety of the precursors of the cathepsin B-like proteinase (PCBt). The largest precursor has an apparent molecular size (Mr) of 45-47 Kd and it contains 3 N-linked oligosaccharide chains which were Endo beta N acetylglucosaminidase H (Endo H)-resistant forms. On ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(89)90030-x
更新日期:1989-04-01 00:00:00
abstract::Cancer prevention techniques include legislative regulation, chemoprevention, adherence to a "healthful" lifestyle, and specialized medical intervention. Attempts at cancer prevention have possibly avoided a dramatic increase in cancer incidence and mortality due to increasing dependence on the products of the chemica...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/0304-3835(90)90172-t
更新日期:1990-04-09 00:00:00
abstract::Eighty samples of cervical invasive squamous cell carcinoma were examined for ras gene mutations using polymerase chain reaction (PCR) followed by restriction enzyme digestion. We found 28 (35%) cervical cancers contained ras mutations at H-ras codon 12, 49 (61%) at K-ras codon 12, and 5 (6%) at K-ras codon 13. There ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(95)03857-s
更新日期:1995-08-16 00:00:00
abstract::The biological characteristic cell locomotion and invasion, melanin content, metalloproteinases and telomerase activity were studied in a parental mouse melanoma cell line B16 and two descendents B16BL6 and B16F10. The invasive potential of melanoma cells was assayed in a transwell cell culture chamber. Melanin conten...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(00)00656-x
更新日期:2001-01-01 00:00:00
abstract::Though significant progress has been made in the availability of diagnostic techniques and treatment strategies, pancreatic cancer remains a disease of high mortality rates. Therefore, there is an urgent need for a better understanding of the molecular mechanisms that governs the oncogenesis and metastasis process of ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.12.014
更新日期:2017-03-01 00:00:00
abstract::Apatinib, a novel tyrosine kinase inhibitor (TKI), has been confirmed for its efficacy and safety in the treatment of advanced gastric carcinoma and some other solid tumors. However, the direct functional mechanisms of tumor lethality mediated by apatinib have not yet been fully characterized, and the precise mechanis...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2018.05.046
更新日期:2018-09-01 00:00:00
abstract::Staurosporine and its derivative 7-hydroxystaurosporine are protein kinase inhibitors that are being considered for treatments of cancers. Several recent studies have shown that cells with defective pRB protein are resistant to the G(1) cell cycle-inhibiting effects of staurosporine compounds. In this study, we examin...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(02)00101-5
更新日期:2002-09-08 00:00:00
abstract::HGT cells are a human gastric cell line derived from a tumour of the stomach. We have investigated the effects of lipoxygenase and cyclooxygenase metabolism inhibitors on HGT cell proliferation, on fatty acid composition of HGT cells and on the incorporation and distribution of arachidonic acid (AA) in HGT lipids. The...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90189-g
更新日期:1993-09-15 00:00:00
abstract::EGCG [(-)epigallocatechin-3-gallate], a green tea-derived polyphenol, has been shown to suppress cancer cell proliferation, and interfere with the several signaling pathways and induce apoptosis. Practically, there is emerging evidence that EGCG has a potential to increase the efficacy of chemotherapy in patients. We ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2006.03.030
更新日期:2007-03-08 00:00:00
abstract::We planned to determine the relationship between angiogenesis and p53 mutational status in advanced-stage epithelial ovarian cancer. Using 190 tumor samples from patients with stage III and IV ovarian cancer we performed p53 sequencing, immunohistochemistry, and CD31 microvessel density (MVD) determination. MVD was el...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2012.12.016
更新日期:2013-04-30 00:00:00
abstract::Loss of heterozygosity (LOH) in the 10q21 region that harbors the tumor suppressor gene ANX7-GTPase gene have been found in 35% of prostate tumors. Therefore, the rationale for this study is that this gene could also be implicated in breast pathogenesis as well. We investigated allelic losses in microsatellites of the...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.01.018
更新日期:2004-07-16 00:00:00
abstract::Effects of eight heterocyclic amines (HCAs) on pancreatic duct carcinogenesis were investigated in a rapid production model in hamsters. N-Nitrosobis(2-oxopropyl)amine (BOP) was given to effect initiation, followed by augmentation pressure consisting of four daily i.p. injections of 500 mg/kg DL-ethionine, a choline-d...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(99)00131-7
更新日期:1999-09-01 00:00:00
abstract::When injected into female NMRI mice tumour necrosis factor-alpha (TNF) produced a dose-related weight loss over the first 24 h, which was accompanied by and directly proportional to a decrease in both food and water intake. Body composition analysis after the first 8 h revealed that the weight loss was associated with...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(89)90072-4
更新日期:1989-06-01 00:00:00
abstract::Bcl-2 agonist of cell death (BAD) is a BH3-only member of the Bcl-2 family which possesses important regulatory function in apoptosis. BAD has also been shown to possess many non-apoptotic functions closely linked to cancer including regulation of glycolysis, autophagy, cell cycle progression and immune system develop...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2017.11.017
更新日期:2018-02-28 00:00:00
abstract::Associations between lung cancer risk and common polymorphisms in the DNA repair genes xeroderma pigmentosum complementation group D (XPD), X-ray repair cross-complementing group 1 (XRCC1), XRCC3 and apurinic/apyrimidinic endonuclease/redox factor 1 were examined within a randomized clinical trial designed to determin...
journal_title:Cancer letters
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0304-3835(02)00638-9
更新日期:2003-03-10 00:00:00
abstract::Human papillomavirus (HPV) DNA integrations may affect therapeutic responses in cancers through ATM network-related DNA damage response (DDR). We studied whether cisplatin-induced DDR was altered in human HK-2 renal tubular cells immortalized by HPV16 E6/E7 genes. Cytotoxicity assays utilized thiazolyl blue dye and DD...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2014.11.008
更新日期:2015-01-28 00:00:00
abstract::Spectroscopic techniques have demonstrated that in the microscopically normal mucosa, there is an increase in mucosal micro-circulation in patients harboring neoplasia elsewhere in the colon (i.e. marker of field carcinogenesis). However, the physiological and molecular basis of this early increase in blood supply (EI...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2011.03.008
更新日期:2011-07-28 00:00:00
abstract::Ovarian cancer represents the leading cause of death among patients with gynecological cancer. The genetic changes underlying the initiation and progression of ovarian cancer have not been well defined. However, non-random structural chromosomal changes have been identified with common chromosomal breakpoints. We have...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2005.04.010
更新日期:2006-04-08 00:00:00
abstract::The clinical use of chemotherapy in cancer treatment is limited by the occurrence of multidrug resistance (MDR) associated with the overexpression of membrane transporters, one of the best known is P-glycoprotein (Pgp), that actively expels drugs out of tumor cells. To overcome Pgp-mediated MDR, synthetic peptides cor...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2007.04.001
更新日期:2007-11-18 00:00:00
abstract::Polyphenolic antioxidants protected against Al-phthalocyanine tetrasulfonate-sensitized photohemolysis of human erythrocytes. A quantitative structure-activity relationship has been obtained to describe the protective effects of di- and trihydroxybenzenes: log cI(50) (microM)=(1.8620+/-1.5565)+(3.6366+/-2.8245) E(1)(7...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(00)00469-9
更新日期:2000-08-31 00:00:00
abstract::Epstein-Barr virus (EBV) has been well documented in the aetiology of nasopharyngeal carcinoma (NPC), although its role as well as the genetic basis in the genesis of NPC have not been elucidated. The p53 gene mutations are infrequently found in NPC, but the expression of p53 protein, as well as bcl-2 oncoprotein, has...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(00)00582-6
更新日期:2000-11-28 00:00:00
abstract::The AT-rich interaction domain 1A (ARID1A, also known as BAF250a) is a chromatin remodeling gene, which frequently mutates across a broad spectrum of cancers with loss expression of the ARID1A protein. Recently, the association between ARID1A deficiency and immune checkpoint blockade (ICB) therapy has been reported. A...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2020.01.001
更新日期:2020-03-31 00:00:00
abstract::The past two decades have seen a dramatic change in cancer treatment paradigms. Anticancer agents are no longer being developed based on empiricism and serendipity, but are now being aimed to inhibit a validated target that is relatively specific for tumours rather than normal cells. The vast majority of cancers arise...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2006.03.012
更新日期:2007-01-08 00:00:00