Reversal of weight loss induced by tumour necrosis factor-alpha.

abstract：:Cancer results from the interaction of multiple aberrations including activation of dominant oncogenes and upregulation of signal transduction pathways. Identification of the genes involved in malignant transformation is a pre-requisite for understanding cancer and improving its diagnosis and treatment. Quite a few of...

journal_title：Cancer letters

authors： Katzav S

更新日期：2007-10-08 00:00:00

abstract：:Gene-silencing with targeted siRNAs has great potential as a therapeutic approach for various diseases including cancer. However, intracellular delivery of siRNA is challenging. We used bovine milk exosomes as a novel system for siRNA delivery. First, we demonstrated that exosomes can deliver endogenous RNA payloads i...

journal_title：Cancer letters

authors： Aqil F,Munagala R,Jeyabalan J,Agrawal AK,Kyakulaga AH,Wilcher SA,Gupta RC

更新日期：2019-05-01 00:00:00

abstract：:Cervical cytology specimens prepared as monolayers were analyzed with a combination of high-resolution single-cell image analysis and lower-resolution contextual image analysis. For the latter, quantitative features of cluster architecture, object distribution and background were used to mimic the pathologists global ...

journal_title：Cancer letters

authors： Zahniser DJ,Isenstein LM,Hutchinson ML

更新日期：1994-03-15 00:00:00

abstract：:The exact role of mast cells in tumor growth is not clear and multifaceted. In some cases, mast cells stimulate while in others inhibit this process. This dual role may be explained to some extent by the huge number of bioactive molecules stored in mast cell granules, as well as differences between tumor microenvironm...

journal_title：Cancer letters

authors： Ribatti D,Tamma R,Crivellato E

更新日期：2018-10-01 00:00:00

abstract：:A single administration of enantiomerically pure 11,12-dihydrodiols of dibenzo[a,l]pyrene (DB[a,l]P) on the back of NMRI mice and subsequent chronic treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) (initiation/promotion assay) revealed strikingly different carcinogenic activities of both enantiomers. Tumor-in...

journal_title：Cancer letters

authors： Luch A,Friesel H,Seidel A,Platt KL

更新日期：1999-03-01 00:00:00

abstract：:The intracellular concentrations of adenosine 3',5'-cyclic monophosphate (cAMP) in colonic tumors induced in adult male Holtzman rats by 1,2-dimethylhydrazine (DMH) were found to be 1/2 the concentration found in normal large bowel tissue. Intracellular concentrations of guanosine 3'-5'-cyclic monophosphate (cGMP) in ...

journal_title：Cancer letters

authors： Stevens RH,Loven DP,Osborne JW,Prall JP,Lawson AJ

更新日期：1978-01-01 00:00:00

abstract：:Ditercalinium (7-H-pyridocarbazole dimer), a prospective antitumor drug, is a bis-intercalator characterized by a very high affinity towards nucleic acids. Specificity of binding of this drug has been studied using spectroscopy and flow cytometry. The competition experiments between the drug and 4',6-diamidino-2-pheny...

journal_title：Cancer letters

authors： Kapuscinski J,Traganos F,Darzynkiewicz Z

更新日期：1988-11-01 00:00:00

abstract：:Methylation of liver and nasal mucosal DNA at the O6 position of guanine (O6-MeG) was measured in intact and castrated male rats after a dose of N-nitrosobis(2-oxopropyl)amine (BOP) (20 mg/kg; i.p.). There were no differences in O6-MeG persistence in liver DNA from either group. In the nasal mucosa more O6-MeG was det...

journal_title：Cancer letters

authors： Lawson TA

更新日期：1990-08-01 00:00:00

abstract：:Berberine, an isoquinoline alkaloid, has a wide range of pharmacological effects, including anti-inflammation, yet the exact mechanism is unknown. Because cyclooxygenase-2 (COX-2) plays a key role in prostaglandins (PGs) synthesis, which is elevated in inflammation, we examined whether the anti-inflammatory mechanism ...

journal_title：Cancer letters

authors： Kuo CL,Chi CW,Liu TY

更新日期：2004-01-20 00:00:00

abstract：:This study investigated the role of miR-206 in estrogen receptor-α (ERα)-positive endometrial endometrioid adenocarcinoma (EEC). We profiled miR-206 expression in 30 EEC clinical samples using qRT-PCR, and explored its relationship with ERα and clinical parameters. A luciferase reporter assay assessed the ERα targetin...

journal_title：Cancer letters

authors： Chen X,Yan Q,Li S,Zhou L,Yang H,Yang Y,Liu X,Wan X

更新日期：2012-01-01 00:00:00

abstract：:It is known that hepatocyte growth factor binding to its receptor regulates gastric cancer progression and metastasis. HGF was found to up-regulate the expression of cyclooxygenase-2 gene and increases prostaglandin (PG) synthesis in gastric mucosa cells. Overexpression of COX-2 and increased PG secretion have also be...

journal_title：Cancer letters

authors： Chen JH,Wu CW,Kao HL,Chang HM,Li AF,Liu TY,Chi CW

更新日期：2006-08-08 00:00:00

abstract：:In the present study, we show that concomitant inhibition of Hedgehog (HH) signaling by the glioma-associated oncogene homolog1 (GLI1)-targeting agent GANT61 and the antiapoptotic BCL-2 protein family member MCL-1 by A-1210477 synergistically induces cell death in HH-driven cancers, i.e. rhabdomyosarcoma (RMS) and med...

journal_title：Cancer letters

authors： Meister MT,Boedicker C,Linder B,Kögel D,Klingebiel T,Fulda S

更新日期：2019-11-28 00:00:00

abstract：:We have developed an epithelial cell line derived from mouse liver which represents a spectrum of malignant progression. When inoculated into mice at low passage, the cells induced benign cysts; after extensive subcultures, the same line induced low grade adenocarcinomas. A variant of these cells with increased invasi...

journal_title：Cancer letters

authors： Dollbaum CM,Anderson LW,Smith HS

更新日期：1980-12-01 00:00:00

abstract：:Iron-enriched diets caused an increase of tumor rate in two models of dimethylhydrazine(DMH)-induced colon tumorigenesis in mice. The effect was independent of the time the iron-diet was fed, i.e. during DMH-treatment or following the DMH-treatment period. The increase of tumor rate depended on the iron concentration ...

journal_title：Cancer letters

authors： Siegers CP,Bumann D,Trepkau HD,Schadwinkel B,Baretton G

更新日期：1992-08-31 00:00:00

abstract：:Okadaic acid, a potent tumor promoter and an inhibitor of protein phosphatase 1 and 2A, has also been characterized as an angiogenic inducer in the chorioallantoic membrane of the chick embryo. To elucidate the roles of okadaic acid on angiogenic processes, we conducted in vitro angiogenesis assays. In this study, we ...

journal_title：Cancer letters

authors： Kim YS,Ahn KH,Kim SY,Jeong JW

更新日期：2009-04-08 00:00:00

abstract：:Loss of heterozygosity (LOH) in the 10q21 region that harbors the tumor suppressor gene ANX7-GTPase gene have been found in 35% of prostate tumors. Therefore, the rationale for this study is that this gene could also be implicated in breast pathogenesis as well. We investigated allelic losses in microsatellites of the...

journal_title：Cancer letters

authors： Leighton X,Srikantan V,Pollard HB,Sukumar S,Srivastava M

更新日期：2004-07-16 00:00:00

abstract：:The widespread consumption of tea as beverage throughout the world has stimulated interest in the possibility of its use in chemoprevention of cancer. The present set of investigation was carried out to evaluate the anticarcinogenic activity of black tea using lung tumorigenesis model in Swiss albino mice. Diethylnitr...

journal_title：Cancer letters

authors： Shukla Y,Taneja P

更新日期：2002-02-25 00:00:00

abstract：:Three sections of brain tissue from 2,657 female C57BL/6 mice were stained with hematoxylin and eosin and evaluated microscopically for proliferative lesions. Mice had been treated with either split-dose ionizing radiation (0, 3.0, 4.0 and 5.1 Gy), chronic lifetime 60 Hz circularly polarized magnetic field exposure (a...

journal_title：Cancer letters

authors： Kharazi AI,Babbitt JT,Hahn TJ

更新日期：1999-12-01 00:00:00

abstract：:Eighty samples of cervical invasive squamous cell carcinoma were examined for ras gene mutations using polymerase chain reaction (PCR) followed by restriction enzyme digestion. We found 28 (35%) cervical cancers contained ras mutations at H-ras codon 12, 49 (61%) at K-ras codon 12, and 5 (6%) at K-ras codon 13. There ...

journal_title：Cancer letters

authors： Wong YF,Chung TK,Cheung TH,Lam SK,Xu YG,Chang AM

更新日期：1995-08-16 00:00:00

abstract：:The monoclonal antibody against the AC133 epitope of CD133 has been widely used as a cell surface marker of cancer stem cells in several different cancer types. Here, we describe the isolation and characterisation of two RNA aptamers, including the smallest described 15 nucleotide RNA aptamer, which specifically recog...

journal_title：Cancer letters

authors： Shigdar S,Qiao L,Zhou SF,Xiang D,Wang T,Li Y,Lim LY,Kong L,Li L,Duan W

更新日期：2013-03-01 00:00:00

abstract：:Mice with hereditary intestinal polyposis have mutations of the APC gene which causes formation of multiple polyps. At least one other gene influences the susceptibility for development of polyps in mice, and the locus was named Mom1. The causative gene for the Mom1 locus has recently been cloned and was found to be i...

journal_title：Cancer letters

authors： Kawamata N,Seriu T,Bartram CR,Koeffler HP

更新日期：1997-01-01 00:00:00

abstract：:Poly(ADP-ribose) synthetase activity in human cervical cancer cell nuclei was found to be approximately twice that of normal cervical cell nuclei. Using antipoly(ADP-ribose) antibody, frozen section of normal tissue were stained by indirect-immunofluorescence and it was demonstrated that the fluorescence of nuclei in ...

journal_title：Cancer letters

authors： Fukushima M,Kuzuya K,Ota K,Ikai K

更新日期：1981-12-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the most common neoplasms and a leading cause of death related to cancer worldwide. Hereditary nonpolyposis colorectal cancer (HNPCC) is the most frequent autosomal dominant predisposition to the development of CRC, accounting for approximately 2.5% of the total CRC burden in Spain. G...

journal_title：Cancer letters

authors： Castellví-Bel S,Castells A,Strunk M,Ferrández A,Piazuelo E,Milà M,Piñol V,Rodríguez-Moranta F,Andreu M,Lanas A,Piqué JM,Gastrointestinal Oncology Group of the Spanish Gastroenterological Association.

更新日期：2005-07-08 00:00:00

abstract：:Increasing evidence points to a fundamental role for cancer stem cells (CSC) in the initiation and propagation of many tumors. As such, in the context of glioblastoma multiforme (GBM), the development of treatment strategies specifically targeted towards CSC-like populations may hold significant therapeutic promise. T...

journal_title：Cancer letters

authors： Ehtesham M,Mapara KY,Stevenson CB,Thompson RC

更新日期：2009-02-18 00:00:00

abstract：:Inclusion of 10% ethanol with 6.8 ppm N-nitrosodiethylamine in the drinking water of strain A male mice resulted in a 4-fold enhancement of multiplicity of lung tumors and a 16-fold increase in incidence of fore-stomach tumors, compared with carcinogen alone. Given with 40 ppm N-nitrosopyrrolidine, ethanol caused a 5....

journal_title：Cancer letters

authors： Anderson LM,Carter JP,Driver CL,Logsdon DL,Kovatch RM,Giner-Sorolla A

更新日期：1993-01-15 00:00:00

abstract：:The tissue-specific glycosylation of the carcinoma (CA)-associated antigen epithelial cell adhesion molecule (EpCAM) was studied in 60 patients suffering from head and neck CAs, and 26 pairs of autologous healthy thyroid and CA biopsies. EpCAM was glycosylated in all tumor samples in which its expression was detectabl...

journal_title：Cancer letters

authors： Pauli C,Münz M,Kieu C,Mack B,Breinl P,Wollenberg B,Lang S,Zeidler R,Gires O

更新日期：2003-04-10 00:00:00

abstract：:Serial determinations of urinary biopterin were performed in rats during the development of lung tumors induced by radon inhalation and 5,6-benzonaphtoflavone administration. A striking increase in biopterin levels was observed in animals which developed single or multiple epidermoid carcinoma of the lung and this inc...

journal_title：Cancer letters

authors： Mura P,Morlier JP,Barriere M,Bredon P,Papet Y,Chameaud J

更新日期：1990-10-08 00:00:00

abstract：:Heparanase (HPA) is an endoglucuronidase that can promote the shedding of associated cytokines in several types of tumors. However, little is known about what controls the expression of HPA or its role in gastric cancer. In this study, we report for the first time that HGF regulates HPA expression to promote gastric c...

journal_title：Cancer letters

authors： Hao NB,Tang B,Wang GZ,Xie R,Hu CJ,Wang SM,Wu YY,Liu E,Xie X,Yang SM

更新日期：2015-05-28 00:00:00

abstract：:We describe here the establishment of a new synovial sarcoma cell line, SYO-1, derived from a biphasic synovial sarcoma that developed in the groin of a 19-year-old female. The cell line was maintained for more than 70 passages (more than 24 months) in vitro. The SYO-1 cells in monolayer culture exhibited a spindle sh...

journal_title：Cancer letters

authors： Kawai A,Naito N,Yoshida A,Morimoto Y,Ouchida M,Shimizu K,Beppu Y

更新日期：2004-02-10 00:00:00

abstract：:It is now well established that increased programmed death-1-ligand 1 (PD-L1) surface expression in cancer cells and the resultant T cell suppression contribute to cancer cell immune evasion. Blockade of PD-L1 function has been shown to stimulate anti-cancer immunity. Therefore, compounds that can down-regulate PD-L1 ...

journal_title：Cancer letters

authors： Liang M,Yang H,Fu J

更新日期：2009-04-08 00:00:00