Abstract：
:Methylation of liver and nasal mucosal DNA at the O6 position of guanine (O6-MeG) was measured in intact and castrated male rats after a dose of N-nitrosobis(2-oxopropyl)amine (BOP) (20 mg/kg; i.p.). There were no differences in O6-MeG persistence in liver DNA from either group. In the nasal mucosa more O6-MeG was detected in DNA from intact rats than in that from castrated rats. The maximum values were 61 (intact) and 35 (castrated) mumols/mol guanine. T/2 were 84 h (intact) and 24 h (castrated). These situations corresponded with changes in O6-MeG-DNAmethyl-transferase (MT) activity, which increased 6-fold in the nasal mucosa by castration resulting in less O6-MeG in the nasal mucosa. In the liver castration halved MT activity but did not produce a comparable change in O6-MeG levels. The mutagenicity of BOP in V79 cells increased almost 2-fold when a liver homogenate from castrated rats was used as the activating system. There was a comparable decline in mutagenicity when a nasal mucosa tissue homogenate from castrated rats was used.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Lawson TAdoi
10.1016/0304-3835(90)90008-lsubject
Has Abstractpub_date
1990-08-01 00:00:00pages
39-43issue
1eissn
0304-3835issn
1872-7980pii
0304-3835(90)90008-Ljournal_volume
53pub_type
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