Non-specific cyclic nucleotide binding in leukemic leukocytes.

abstract：:Rituximab is the first anti-cancer antibody approved by the FDA for the treatment of B-cell lymphoma. However, its efficacy remains variable and often modest. Some patients are initially unresponsive to rituximab or later develop resistance to it, and require alternative therapies. Rituximab activity has been thought ...

journal_title：Cancer letters

authors： Lv M,Lin Z,Qiao C,Gen S,Lang X,Li Y,Feng J,Shen B

更新日期：2010-08-01 00:00:00

abstract：:Two-month-old outbred female LIO rats were exposed weekly to 15 (experiment I, groups 1, 2 and 3) or to 5 (experiment II, groups 4, 5 and 6) subcutaneous injections of 1,2-dimethylhydrazine (DMH) at a single dose of 21 mg/kg of body weight. From the day of the first injection of the carcinogen, the rats from groups 2,...

journal_title：Cancer letters

authors： Anisimov VN,Zabezhinski MA,Popovich IG,Berstein LM,Kovalenko IG,Lieberman AI,Shmidt JL

更新日期：1999-04-26 00:00:00

abstract：:Tumor biopsies obtained from 25 Saudi Arab patients with nasopharyngeal carcinoma (NPC) were examined for the presence of Epstein-Barr virus (EBV) DNA detected by the polymerase chain reaction (PCR) and for the incidence of p53 mutations screened by a combination of PCR, single strand conformation polymorphism (SSCP) ...

journal_title：Cancer letters

authors： Nasrin N,Taiba K,Hannan N,Hannan M,al-Sedairy S

更新日期：1994-07-29 00:00:00

abstract：:The ability of the cytosolic arylamine oxidase to convert structurally diverse aromatic and heterocyclic amines to mutagens in the Ames test was investigated using hepatic cytosol from Aroclor 1254-treated rats as the activation system. Using this system, only amino compounds containing at least three fused aromatic r...

journal_title：Cancer letters

authors： Marczylo T,Ioannides C

更新日期：1998-05-15 00:00:00

abstract：:A rabbit gamma delta killer T-cell line against Shope carcinoma cells was established from peripheral blood lymphocytes (PBL) of a human T-lymphotropic virus type I (HTLV-I)-infected rabbit bearing Shope papilloma and carcinoma. Southern hybridization analysis of this cell line with an HTLV-I probe showed that the cel...

journal_title：Cancer letters

authors： Kim CJ,Isono T,Tomoyoshi T,Seto A

更新日期：1995-02-10 00:00:00

abstract：:Human mitogen-stimulated lymphocytes, cultured in the presence of amosite asbestos (AS), demonstrated a slight increase in aryl hydrocarbon hydroxylase (AHH) activity compared with non-induced (control) cultures (P = 0.005). A much greater increase in enzyme activity occurred following addition of the inducers benzant...

journal_title：Cancer letters

authors： McLemore TL,Jenkins WT,Arnott MS,Wray NP

更新日期：1979-07-01 00:00:00

abstract：:Vitamin C has been suggested and disputed as an anti-cancer agent. Previous in vitro studies using either primary cell cultures from cancer patients or tumor cell lines have suggested that tumor cells with different lineages may have different sensitivities to ascorbic acid. In this study we report characterization of...

journal_title：Cancer letters

authors： Kao TL,Meyer WJ 3rd,Post JF

更新日期：1993-06-15 00:00:00

abstract：:A newly found human retrovirus, adult T-cell leukemia virus (ATLV) was shown by means of membrane immunofluorescence to bind to various hematopoietic cells including T-, B- and non-T, non-B-cell lines. Partially purified viral gp46 from culture fluids of ATL virus producer lines also bound efficiently to an ATLV-negat...

journal_title：Cancer letters

authors： Yamamoto N,Chosa T,Koyanagi Y,Tochikura T,Schneider J,Hinuma Y

更新日期：1984-01-01 00:00:00

abstract：:This study tested the effect of intratumoral injection with activated tumor-infiltrating lymphocytes (TIL), and simultaneous administration of recombinant interleukin-2 (rIL-2) and interferon alpha (IFN-alpha) (LII protocol), on mouse liver tumor. Group I (n = 10) served as the controls. Group II (n = 17) received rIL...

journal_title：Cancer letters

authors： Liu DL,Håkansson CH,Seifert J

更新日期：1994-09-30 00:00:00

abstract：:CYP1A1, CYP2E1 and GSTM1 polymorphisms were evaluated in Chilean healthy controls and lung cancer patients. In the Chilean healthy group, frequencies of CYP1A1 variant alleles for MspI (m2 or CYP1A1*2A) and ile/val (val or CYP1A1*2B) polymorphisms were 0.25 and 0.33, respectively. Frequencies of variant alleles C (CYP...

journal_title：Cancer letters

authors： Quiñones L,Lucas D,Godoy J,Cáceres D,Berthou F,Varela N,Lee K,Acevedo C,Martínez L,Aguilera AM,Gil L

更新日期：2001-12-10 00:00:00

abstract：:Malachite green (MG), an industrial compound and potential environmental health hazard, is highly cytotoxic to mammalian cells in culture. In an attempt to define the biochemical basis, we have compared the cytotoxic effects and morphological alterations shown by MG in Syrian hamster embryo (SHE) cells with the levels...

journal_title：Cancer letters

authors： Panandiker A,Fernandes C,Rao KV

更新日期：1992-12-24 00:00:00

abstract：:CD95, TNFR1, TRAILR1 and TRAILR2 belong to a subgroup of TNF receptors which is characterized by a conserved cell death-inducing protein domain that connects these receptors to the apoptotic machinery of the cell. Activation of death receptors in malignant cells attracts increasing attention as a principle to fight ca...

journal_title：Cancer letters

authors： Wajant H,Gerspach J,Pfizenmaier K

更新日期：2013-05-28 00:00:00

abstract：:The exact role of mast cells in tumor growth is not clear and multifaceted. In some cases, mast cells stimulate while in others inhibit this process. This dual role may be explained to some extent by the huge number of bioactive molecules stored in mast cell granules, as well as differences between tumor microenvironm...

journal_title：Cancer letters

authors： Ribatti D,Tamma R,Crivellato E

更新日期：2018-10-01 00:00:00

abstract：:Co-transfer of immunomodulatory and antiproliferative genes may be the basis for new strategies to potentiate tumor regression. In this study, we evaluated the in vitro effect of the introduction of human wild-type p53, granulocyte-macrophage colony-stimulating factor (GM-CSF), and B7-1 genes via recombinant adenoviru...

journal_title：Cancer letters

authors： Qiu ZH,Wu CT,Lao MF,Pan LZ,Li YM

更新日期：2002-08-28 00:00:00

abstract：:Retinoic acid and retinol induced functional and morphological differentiation of human promyelocytic leukemia cells (HL-60) into mature granulocytes, but did not induce functional or morphological differentiation of mouse myeloid leukemia cells (M1). Cellular retinoic acid-binding protein, but not retinol-binding pr...

journal_title：Cancer letters

authors： Takenaga K,Honma Y,Hozumi M

更新日期：1981-06-01 00:00:00

abstract：:Condensed roofing asphalt fumes, generated at 316 degrees C, were collected by cold trap condensation and fractionated by preparative high performance liquid chromatography. Chemical classes in each of the fractions (A-E) were identified by gas chromatography/mass spectroscopy. The fractions, various combinations of f...

journal_title：Cancer letters

authors： Sivak A,Niemeier R,Lynch D,Beltis K,Simon S,Salomon R,Latta R,Belinky B,Menzies K,Lunsford A,Cooper C,Ross A,Bruner R

更新日期：1997-07-15 00:00:00

abstract：:Previously, we showed that hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, carbonic anhydrase IX (CA IX), and vascular endothelial growth factor (VEGF) were frequently coexpressed in tumor biopsies from patients of nasopharyngeal carcinoma (NPC) and were associated with poor outcome after radiotherapy. Here, we fur...

journal_title：Cancer letters

authors： Sung FL,Hui EP,Tao Q,Li H,Tsui NB,Lo YM,Ma BB,To KF,Harris AL,Chan AT

更新日期：2007-08-08 00:00:00

abstract：:Imatinib has revolutionized treatment strategies for chronic myeloid leukemia patients: long-term overall survival was reported to be up to 80% at 8 years of follow-up in respondent patients. Despite the straightforward results obtained, it has been estimated a failure rate per year of 2-4%. Several attempts to improv...

journal_title：Cancer letters

authors： Breccia M,Alimena G

更新日期：2012-09-28 00:00:00

abstract：:Lysophosphatidic acid (LPA) receptors including LPA(1), LPA(2), and LPA(3) mediate lysophosphatidic acid signals. We analyzed the expression of LPA receptors, vascular endothelial growth factor (VEGF), and interleukin-8 in 97 patients from normal ovary to ovarian cancer, using reverse transcription polymerase chain re...

journal_title：Cancer letters

authors： Fujita T,Miyamoto S,Onoyama I,Sonoda K,Mekada E,Nakano H

更新日期：2003-03-31 00:00:00

abstract：:Boesenbergia pandurata (Zingiberaceae), Languas galanga (Zingiberaceae) and Citrus hystrix (Rutaceae) are edible plants that are commonly used as flavors or condiments in various Thai food dishes. They are known to exert strong anti-promoting activity in a test of tumor promoter-induced Epstein-Barr virus (EBV) activa...

journal_title：Cancer letters

authors： Tiwawech D,Hirose M,Futakuchi M,Lin C,Thamavit W,Ito N,Shirai T

更新日期：2000-10-01 00:00:00

abstract：:The efficacy and mechanism of action of cisplatin and gemcitabine were investigated in a panel of neuroblastoma cell lines and multicellular tumor spheroids. In neuroblastoma spheroids, the combination of cisplatin and gemcitabine induced a complete cytostasis at clinical relevant concentrations. A synergistic effect ...

journal_title：Cancer letters

authors： Besançon OG,Tytgat GA,Meinsma R,Leen R,Hoebink J,Kalayda GV,Jaehde U,Caron HN,van Kuilenburg AB

更新日期：2012-06-01 00:00:00

abstract：:Although the concept of employing ultrasound for the treatment of cancer is not a new one, virtually all existing ultrasound-based clinical cancer treatments are based on hyperthermic ablation. This review seeks to highlight the potential offered by more subtle ultrasound-triggered phenomena such as sonoporation in de...

journal_title：Cancer letters

authors： Nomikou N,McHale AP

更新日期：2010-10-28 00:00:00

abstract：:To determine the genotoxic risk associated with therapeutic exposure to 131I, we studied the presence of micronuclei (MN) in binucleated peripheral blood lymphocytes of a group of 22 women, patients of thyroid cancer, who received 131I sodium iodide orally as an adjuvant after total thyroidectomy. The cytogenetic stud...

journal_title：Cancer letters

authors： Gutiérrez S,Carbonell E,Galofréa P,Xamena N,Creus A,Marcos R

更新日期：1995-05-08 00:00:00

abstract：:Liver hyperplasia was induced in rats by daily administration of methylclofenapate (25 mg/kg by gavage). An increase in the incidence of colchicine-arrested metaphases was observed with peaks occurring at 40 h (1.3%), 64 h (6.4%) and 84 h (6.8%) after the start of treatment. This response contrasted with the much larg...

journal_title：Cancer letters

authors： Bybee A,Styles JA,Beck SL,Blackburn D

更新日期：1990-07-16 00:00:00

abstract：:The development of multidrug resistance (MDR) to chemotherapy remains a major challenge in the treatment of cancer. Numerous mechanisms have been recognized that cause MDR, but one of the most important mechanisms is overexpression of adenosine triphosphate (ATP)-binding cassette (ABC) transporters, through which the ...

journal_title：Cancer letters

authors： Fan YF,Zhang W,Zeng L,Lei ZN,Cai CY,Gupta P,Yang DH,Cui Q,Qin ZD,Chen ZS,Trombetta LD

更新日期：2018-05-01 00:00:00

abstract：:In situ markers for quantitative analysis of cell proliferation and apoptotic cell death have been used to evaluate both the proliferation level and net growth potential of preneoplastic nodules and malignant tumor tissues from rats experimentally induced for hepatocarcinogenesis by the dietary administration of 2-ace...

journal_title：Cancer letters

authors： Kong J,Ringer DP

更新日期：1996-08-02 00:00:00

abstract：:Protein kinase C epsilon (PKCε), a member of the novel PKC family, is known to be a transforming oncogene and tumor biomarker for many human solid cancers including renal cell carcinoma (RCC). We isolated side population (SP) cells from the RCC 769P cell line, and proved that those cells possess cancer stem cell (CSC)...

journal_title：Cancer letters

authors： Huang B,Fu SJ,Fan WZ,Wang ZH,Chen ZB,Guo SJ,Chen JX,Qiu SP

更新日期：2016-06-28 00:00:00

abstract：:Two hepatoma cell lines were incubated for 72 h with ATRA and its analog 13cisRA and according to MTT assay, Hep3B cells were highly susceptible whereas HepG2 cells were more resistant to the treatment. At the high concentration of 166 microM, retinoids were able to induce apoptosis in both cell lines and the highest ...

journal_title：Cancer letters

authors： Arce F,Gätjens-Boniche O,Vargas E,Valverde B,Díaz C

更新日期：2005-11-18 00:00:00

abstract：:The AT-rich interaction domain 1A (ARID1A, also known as BAF250a) is a chromatin remodeling gene, which frequently mutates across a broad spectrum of cancers with loss expression of the ARID1A protein. Recently, the association between ARID1A deficiency and immune checkpoint blockade (ICB) therapy has been reported. A...

journal_title：Cancer letters

authors： Hu G,Tu W,Yang L,Peng G,Yang L

更新日期：2020-03-31 00:00:00

abstract：:Though significant progress has been made in the availability of diagnostic techniques and treatment strategies, pancreatic cancer remains a disease of high mortality rates. Therefore, there is an urgent need for a better understanding of the molecular mechanisms that governs the oncogenesis and metastasis process of ...

journal_title：Cancer letters

authors： Liang C,Qin Y,Zhang B,Ji S,Shi S,Xu W,Liu J,Xiang J,Liang D,Hu Q,Ni Q,Yu X,Xu J

更新日期：2017-03-01 00:00:00