Mitosis and histopathology in rat liver during methylclofenapate-induced hyperplasia.

Abstract:

:Liver hyperplasia was induced in rats by daily administration of methylclofenapate (25 mg/kg by gavage). An increase in the incidence of colchicine-arrested metaphases was observed with peaks occurring at 40 h (1.3%), 64 h (6.4%) and 84 h (6.8%) after the start of treatment. This response contrasted with the much larger (21.3%) peak in arrested metaphases at 36 h after partial hepatectomy, but was still unexpectedly large in comparison with the S-phase response to methylclofenapate reported in a previous study. Progressive hypertrophic histopathological changes were apparent during the whole course of treatment.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Bybee A,Styles JA,Beck SL,Blackburn D

doi

10.1016/0304-3835(90)90250-2

subject

Has Abstract

pub_date

1990-07-16 00:00:00

pages

95-100

issue

2

eissn

0304-3835

issn

1872-7980

pii

0304-3835(90)90250-2

journal_volume

52

pub_type

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