Abstract:
:Liver hyperplasia was induced in rats by daily administration of methylclofenapate (25 mg/kg by gavage). An increase in the incidence of colchicine-arrested metaphases was observed with peaks occurring at 40 h (1.3%), 64 h (6.4%) and 84 h (6.8%) after the start of treatment. This response contrasted with the much larger (21.3%) peak in arrested metaphases at 36 h after partial hepatectomy, but was still unexpectedly large in comparison with the S-phase response to methylclofenapate reported in a previous study. Progressive hypertrophic histopathological changes were apparent during the whole course of treatment.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Bybee A,Styles JA,Beck SL,Blackburn Ddoi
10.1016/0304-3835(90)90250-2subject
Has Abstractpub_date
1990-07-16 00:00:00pages
95-100issue
2eissn
0304-3835issn
1872-7980pii
0304-3835(90)90250-2journal_volume
52pub_type
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