A molecular study of EBV DNA and p53 mutations in nasopharyngeal carcinoma of Saudi Arab patients.

abstract：:Hepatocellular cancer (HCC) has always been considered a therapeutic challenge, given the cytoxic drug resistant nature of the cancer and associated disorder in liver function, reducing the safety of many conventional chemotherapy agents. The Multikinase inhibitor sorafenib has been found to prolong survival in patien...

journal_title：Cancer letters

authors： Kerr SH,Kerr DJ

更新日期：2009-12-01 00:00:00

abstract：:The hepatitis B virus (HBV) is a major cause of hepatocellular carcinoma (HCC), partly driven by viral integration and specific oncogenic HBV variants. However, the biological significance of HBV genomes within lymphoid cells (i.e., peripheral blood mononuclear cells, PBMCs) is unclear. Here, we collected available pl...

journal_title：Cancer letters

authors： Lau KC,Joshi SS,Gao S,Giles E,Swidinsky K,van Marle G,Bathe OF,Urbanski SJ,Terrault NA,Burak KW,Osiowy C,Coffin CS

更新日期：2020-06-28 00:00:00

abstract：:In order to understand the differences and similarities between tumorigenic and non-tumorigenic HeLaxhuman fibroblast hybrids, gene expression profiles were examined with synthetic oligonucleotide arrays containing nearly 7000 gene probe sets. We used two pairs of genetically related hybrids, each pair representing in...

journal_title：Cancer letters

authors： Nishizuka S,Winokur ST,Simon M,Martin J,Tsujimoto H,Stanbridge EJ

更新日期：2001-04-26 00:00:00

abstract：:The presence and the involvement of cancer stem-like cells (CSCs) in tumor initiation and progression, and chemo-resistance are documented. Herein, we functionally analyzed melanoma stem-like cells (MSC)/CD133(+) cells on their resistance and response to taxol-induced apoptosis. Besides being taxol resistant, the CD13...

journal_title：Cancer letters

authors： El-Khattouti A,Selimovic D,Haïkel Y,Megahed M,Gomez CR,Hassan M

更新日期：2014-02-01 00:00:00

abstract：:Hepatocyte nodules and hepatocellular carcinomas were induced in male Fischer rats using the resistant hepatocyte model. The immunoreactive cytosolic levels of the heme-binding Z protein (HBP) were reduced by 56% (P less than 0.001; 2-tailed t-test) in early hepatocyte nodules (25 weeks) and hepatocellular carcinomas ...

journal_title：Cancer letters

authors： Roomi MW,Vincent SH,Farber E,Muller-Eberhard U

更新日期：1988-12-01 00:00:00

abstract：:Highly invasive and rapidly fatal, small-cell lung cancer (SCLC) has been an insurmountable gulf since discovery. Innate immunity plays a vital role in anti-tumor response, among which macrophages contribute to an indispensable character. Here, we found that macrophage infiltration in SCLC reduced significantly in a s...

journal_title：Cancer letters

authors： Zheng Y,Wang Z,Wei S,Liu Z,Chen G

更新日期：2021-02-28 00:00:00

abstract：:Overexpression of Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) is implicated in drug resistance and progression of multiple myeloma (MM). The basis for MARCKS induction and impact on MM are not known. Here we show that microRNA-34a (miR-34a), regulates MARCKS translation and is under-expressed in drug-resist...

journal_title：Cancer letters

authors： Zhang L,Rastgoo N,Wu J,Zhang M,Pourabdollah M,Zacksenhaus E,Chen Y,Chang H

更新日期：2020-06-28 00:00:00

abstract：:Antibodies directed against the L1 cell adhesion protein inhibit growth of SKOV3ip human ovarian cancer cells in vitro and in vivo. Responses of SKOV3ip cells in vitro to anti-L1 mAb chCE7 and Genistein were investigated. Genistein potentiated the anti-proliferative and pro-apoptotic effects of chCE7 in SKOV3ip cells....

journal_title：Cancer letters

authors： Novak-Hofer I,Cohrs S,Grünberg J,Friedli A,Schlatter MC,Pfeifer M,Altevogt P,Schubiger PA

更新日期：2008-03-18 00:00:00

abstract：:Vascular mimicry (VM) describes the phenomenon that tumor cells but not endothelial cells form vascular-like channels, which provide blood perfusion for tumor tissues. VM is associated with tumor growth, metastasis and worse survival of different cancers. The mechanisms of VM formation remain largely unknown. We showe...

journal_title：Cancer letters

authors： Yang J,Lu Y,Lin YY,Zheng ZY,Fang JH,He S,Zhuang SM

更新日期：2016-12-01 00:00:00

abstract：:Metastasis remains a formidable problem in malignant tumors. In this study, MTT assay revealed that 4-methyl-3-nitro-benzoic acid (MNBA) had no effect on cell viability and did not interfere with cell cycle in any breast cancer cell lines tested. However, treatment with MNBA on breast cancer cells can inhibit EGF-indu...

journal_title：Cancer letters

authors： Guo H,Li M,Chen P,Blake DJ,Kong X,Hao X,Niu R,Zhang N

更新日期：2011-06-01 00:00:00

abstract：:Accumulating evidence suggested that the irreversible tyrosine kinase inhibitors (TKIs) have potential to override the acquired resistance to target-based therapies. Herein, we reported IC-4 as a novel irreversible TKI for epidermal growth factor receptor (EGFR). IC-4 potentially suppressed proliferation, induced apop...

journal_title：Cancer letters

authors： Li YB,Wang ZQ,Yan X,Chen MW,Bao JL,Wu GS,Ge ZM,Zhou DM,Wang YT,Li RT

更新日期：2013-10-28 00:00:00

abstract：:The cancer chemotherapeutic drug, 5-(3,3-dimethyl-1-triazeno) imidazole-4-carboxamide (DIC, DTIC, NSC-45388), is metabolised in rats to a structurally related product which was detected by thin-layer chromatography. The novel metabolite has a lower mobility and a colour reaction that is indistinguishable from the pare...

journal_title：Cancer letters

authors： Kolar GF,Maurer M,Wildschütte M

更新日期：1980-09-01 00:00:00

abstract：:The basic fraction of tryptophan pyrolysis products (TBF) showed strong mutagenic activity on somatic cells of the lung of Chinese hamsters. In this somatic mutation test, TBF was demonstrated to have 5.6 times higher mutagenicity than diethylnitrosamine (DEN) when mutants were selected with 8-azaguanine, and 13.5-fol...

journal_title：Cancer letters

authors： Inui N,Nishi Y,Hasegawa MM,Kawachi T

更新日期：1980-05-01 00:00:00

abstract：:Development of chemotherapy resistance remains a major obstacle for glioma management. Exosome-mediated transfer of circular RNAs (circRNAs) are being found to have relevance to many human cancers, including glioma. The purpose of this study is to explore the effect and underlying mechanism of exosomal circRNA nuclear...

journal_title：Cancer letters

authors： Ding C,Yi X,Wu X,Bu X,Wang D,Wu Z,Zhang G,Gu J,Kang D

更新日期：2020-06-01 00:00:00

abstract：:BRCA1 and BRCA2 genes were screened for loss-of-function mutations in a series of 85 patients having at least one first- or second-degree relative affected by breast and/or ovarian cancer. All BRCA1 exons and BRCA2 exons 10 and 11 were screened with a combination of methods including SSCP, PTT and direct sequencing. W...

journal_title：Cancer letters

authors： Ladopoulou A,Kroupis C,Konstantopoulou I,Ioannidou-Mouzaka L,Schofield AC,Pantazidis A,Armaou S,Tsiagas I,Lianidou E,Efstathiou E,Tsionou C,Panopoulos C,Mihalatos M,Nasioulas G,Skarlos D,Haites NE,Fountzilas G,Pandis N

更新日期：2002-11-08 00:00:00

abstract：:We used antisense RNA to inhibit the expression of oncogene neu and investigated the effects of diminished neu expression on the phenotypes of B104 cells containing activated oncogene neu. Antisense MT-neu and pSV-neo plasmids were cotransfected into neuroblastoma B104 cells. Southern analysis showed the integration o...

journal_title：Cancer letters

authors： Shaw YT,Chang SH,Chiou ST,Chang WC,Lai MD

更新日期：1993-04-15 00:00:00

abstract：:Previously, we reported that quercetin and resveratrol inhibit the function of androgen receptor (AR). Further studies showed that these two polyphenols caused an increase in expression of c-Jun as well as its phosphorylated form in a dose-dependent manner in prostatic cell lines. Gel shift assay showed that induced c...

journal_title：Cancer letters

authors： Yuan H,Pan Y,Young CY

更新日期：2004-09-30 00:00:00

abstract：:The mammary carcinogenicity of two diol epoxide metabolites of the commonly occurring environmental carcinogen benzo[j]fluoranthene (BjF) was investigated by direct application to the tissue beneath the mammary glands of female CD rats. The compounds tested were trans-4,5-dihydroxy-anti-6,6a.epoxy-4,5,6,6a-tetrahydroB...

journal_title：Cancer letters

authors： Hecht SS,Rivenson A,Amin S,Krzeminski J,el-Bayoumy K,Reddy BS,Kurtzke C,La Voie EJ

更新日期：1996-09-10 00:00:00

abstract：:Activation of the cytoplasmic (Ras-Raf-MEK-ERK) signaling cascade was shown to be both, necessary and sufficient for transformation in vitro as well as in vivo. However, over the last years the involvement of stress-activated protein kinases (SAPKs)/Jun N-terminal kinases (JNKs), and their substrate c-Jun in the proce...

journal_title：Cancer letters

authors： Rennefahrt U,Illert B,Greiner A,Rapp UR,Troppmair J

更新日期：2004-11-08 00:00:00

abstract：:In the present study, we show that concomitant inhibition of Hedgehog (HH) signaling by the glioma-associated oncogene homolog1 (GLI1)-targeting agent GANT61 and the antiapoptotic BCL-2 protein family member MCL-1 by A-1210477 synergistically induces cell death in HH-driven cancers, i.e. rhabdomyosarcoma (RMS) and med...

journal_title：Cancer letters

authors： Meister MT,Boedicker C,Linder B,Kögel D,Klingebiel T,Fulda S

更新日期：2019-11-28 00:00:00

abstract：:Deregulation of cell metabolism is an established cancer hallmark that contributes to tumor initiation and progression, as well as tumor heterogeneity. In solid tumors, alterations in different metabolic pathways, including glycolysis, pentose phosphate pathway, glutaminolysis and fatty acid metabolism, support the hi...

journal_title：Cancer letters

authors： Miranda-Gonçalves V,Lameirinhas A,Henrique R,Baltazar F,Jerónimo C

更新日期：2020-05-01 00:00:00

abstract：:Prolonged exposure to elevated levels of estrogen is a risk factor for breast cancer. Though increased cell growth and loss of DNA repair capacity is one of the proposed mechanisms for estrogen-induced cancers, the mechanism through which estrogen induces cell growth and decreases DNA repair capacity is not clear. DNA...

journal_title：Cancer letters

authors： Singh KP,Treas J,Tyagi T,Gao W

更新日期：2012-03-01 00:00:00

abstract：:The susceptibility of pepsinogen-altered pyloric glands (PAPG) and neoplastic glandular stomach lesions induced by N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and catechol or sodium cholate in Nagase analbuminemic rats (NAR) was compared to Sprague-Dawley rats (SD). Male NAR and SD rats were given a single dose of 80 m...

journal_title：Cancer letters

authors： Ogawa K,Shichino Y,Tatematsu M,Furihata C,Asamoto M,Nagase S,Shirai T,Ito N

更新日期：1995-09-25 00:00:00

abstract：:Emerging evidence indicates that cancer stem cells (CSCs) are involved in tumorigenesis, tumor recurrence, and therapeutic resistance in hepatocellular carcinoma (HCC). However, the mechanisms underlying HCC CSC regulation remain largely unknown. Here we report our analysis of 97 paraffin-embedded HCC tumor specimens....

journal_title：Cancer letters

authors： Fan Z,Duan J,Wang L,Xiao S,Li L,Yan X,Yao W,Wu L,Zhang S,Zhang Y,Li Y,Zhu X,Hu Y,Zhang D,Jiao S,Xu X

更新日期：2019-05-28 00:00:00

abstract：:Cytokines induce inflammatory and immune responses in tumors after photodynamic therapy (PDT). Since there are no reports of IL-6 in nasopharyngeal cancer (NPC) cells following PDT, we evaluated IL-6 expression in two different NPC tumors after hypericin mediated PDT. Interleukin-6 transcription was significantly upre...

journal_title：Cancer letters

authors： Du H,Bay BH,Mahendran R,Olivo M

更新日期：2006-04-28 00:00:00

abstract：:We investigated the relationship between ErbB-2 and HLA in order to clarify the clinical and genetic factors related to Japanese patients with lung cancer. Thirty-nine of the 73 lung cancer patients (53.4%) had elevated levels of ErbB-2. Only seven of 23 (30. 4%) patients with small cell carcinoma had elevated ErbB-2 ...

journal_title：Cancer letters

authors： Yoshimura C,Nomura S,Yamaoka M,Ohtani T,Matsuzakiz T,Yamaguchi K,Fukuharal S

更新日期：2000-04-28 00:00:00

abstract：:The development of multidrug resistance (MDR) to chemotherapy remains a major challenge in the treatment of cancer. Numerous mechanisms have been recognized that cause MDR, but one of the most important mechanisms is overexpression of adenosine triphosphate (ATP)-binding cassette (ABC) transporters, through which the ...

journal_title：Cancer letters

authors： Fan YF,Zhang W,Zeng L,Lei ZN,Cai CY,Gupta P,Yang DH,Cui Q,Qin ZD,Chen ZS,Trombetta LD

更新日期：2018-05-01 00:00:00

abstract：:The effects of trisodium nitrilotriacetate monohydrate (Na3 NTA.H2O) nitrilotriacetic acid (H3NTA) and ammonium chloride (NH4Cl) on two-stage urinary bladder carcinogenesis were examined. Carcinogenesis was initiated by administration of 0.2% N-bis (2-hydroxypropyl)-nitrosamine (DHPN) to male Wistar rats in the drinki...

journal_title：Cancer letters

authors： Kitahori Y,Shimoyama T,Ohshima M,Matsuki H,Hashimoto H,Minami S,Konishi N,Hiasa Y

更新日期：1988-12-01 00:00:00

abstract：:Efficient DNA repair mechanisms comprise a critical component in the protection against human cancer, as indicated by the high predisposition to cancer of individuals with germ-line mutations in DNA repair genes. This includes biallelic germ-line mutations in the MUTYH gene, encoding a DNA glycosylase that is involved...

journal_title：Cancer letters

authors： Paz-Elizur T,Sevilya Z,Leitner-Dagan Y,Elinger D,Roisman LC,Livneh Z

更新日期：2008-07-18 00:00:00

abstract：:Discovery of activating mutations in epidermal growth factor receptor (EGFR) as a predictive biomarker for first-generation EGFR tyrosine kinase inhibitors (TKIs) has initiated an era of precision oncology for the treatment of advanced EGFR-mutant non-small cell lung cancer (NSCLC). Despite the robust efficacy of firs...

journal_title：Cancer letters

authors： Zhang YC,Zhou Q,Wu YL

更新日期：2019-09-10 00:00:00