Abstract:
:Antibodies directed against the L1 cell adhesion protein inhibit growth of SKOV3ip human ovarian cancer cells in vitro and in vivo. Responses of SKOV3ip cells in vitro to anti-L1 mAb chCE7 and Genistein were investigated. Genistein potentiated the anti-proliferative and pro-apoptotic effects of chCE7 in SKOV3ip cells. A combination of mAb chCE7 and Genistein strongly reduced the sensitivity of p44/42 (Erk1,2) kinase, Src kinase and Akt kinase to extracellular stimulation with serum, Epidermal Growth Factor and Hepatocyte Growth Factor. The observed synergy of antibodies directed against L1 with Genistein could lead to a new therapeutic option for ovarian cancer.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Novak-Hofer I,Cohrs S,Grünberg J,Friedli A,Schlatter MC,Pfeifer M,Altevogt P,Schubiger PAdoi
10.1016/j.canlet.2007.11.012subject
Has Abstractpub_date
2008-03-18 00:00:00pages
193-204issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(07)00558-7journal_volume
261pub_type
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