Interstitial and large chromosome 1p deletion occurs in localized and disseminated neuroblastomas and predicts an unfavourable outcome.

abstract：:Very few studies have been reported the function of wild type IDH1 in tumor progress. Previously, we reported that IDH1 correlated with pathological grade and metastatic potential inversely in human osteosarcoma. Here, IDH1 was found lower expressed in osteosarcoma tissues than that of adjacent normal bone tissues. In...

journal_title：Cancer letters

authors： Hu X,Liu Y,Qin C,Pan Z,Luo J,Yu A,Cheng Z

更新日期：2014-04-28 00:00:00

abstract：:Solid tumors are composed of tumor cells and stromal cells including lymphatic endothelial cells (LEC), which are mainly viewed as cells forming lymphatic vessels involved in the transport of metastatic and immune cells. We here reveal a new mechanism by which tumor exposed-LEC (teLEC) exert mitogenic effects on tumor...

journal_title：Cancer letters

authors： Van de Velde M,Ebroin M,Durré T,Joiret M,Gillot L,Blacher S,Geris L,Kridelka F,Noel A

更新日期：2021-01-28 00:00:00

abstract：:We have investigated the effects of hyperthermia on the apoptosis induced by tumor necrosis factor alpha (TNF-alpha). Confluent monolayers of human gastric cancer cell line MKN45 were either treated or untreated with hyperthermia for 1 h. The cells were subsequently stimulated with TNF-alpha. A 24-h incubation with TN...

journal_title：Cancer letters

authors： Kokura S,Yoshida N,Ueda M,Imamoto E,Ishikawa T,Takagi T,Naito Y,Okanoue T,Yoshikawa T

更新日期：2003-11-10 00:00:00

abstract：:VEGF receptor blockage has been reported to increase serum VEGF. We hypothesized that mTOR inhibition by everolimus counteracts VEGF induction by sunitinib resulting in an improved anti-tumor activity of sunitinib. In vitro, sunitinib in combination with everolimus did not outperform the respective monotherapies. In v...

journal_title：Cancer letters

authors： Fuereder T,Jaeger-Lansky A,Hoeflmayer D,Preusser M,Strommer S,Cejka D,Koehrer S,Crevenna R,Wacheck V

更新日期：2010-10-28 00:00:00

abstract：:Enormous efforts have been made to explore small molecules that interfere with the TGF-β signaling pathway, so as to inhibit EMT and the cancer metastasis, but few agents have been identified. In this study, we demonstrated that Nutlin-3 could abolish the down-regulation of E-cadherin induced by TGF-β1 in p53-deficien...

journal_title：Cancer letters

authors： Wu Y,Fu Y,Zheng L,Lin G,Ma J,Lou J,Zhu H,He Q,Yang B

更新日期：2014-01-01 00:00:00

abstract：:Preventive intervention of colorectal cancer has become essential as a major portion of the population may develop the disease at some points during their lives. Diet and nutrition play an important role during this multistep colon carcinogenic process. Inhibitory activity of aqueous suspensions of garlic and tomato, ...

journal_title：Cancer letters

authors： Sengupta A,Ghosh S,Das S

更新日期：2004-05-28 00:00:00

abstract：:Resveratrol is a plant polyphenol found in grapes and red wine. It has been found to have beneficial effects on the cardiovascular system. Resveratrol also inhibits the growth of various tumor cell lines in vitro and inhibits carcinogenesis in vivo. In this study we examined the effect of resveratrol on growth of two ...

journal_title：Cancer letters

authors： Niles RM,McFarland M,Weimer MB,Redkar A,Fu YM,Meadows GG

更新日期：2003-02-20 00:00:00

abstract：:Gastric juice ascorbic acid concentrations were examined in black and white patients. Significantly lower concentrations were found in blacks, in the absence of a significant difference in the plasma concentration of vitamin C between races. Blacks had higher prevalence of Helicobacter pylori infection, higher gastric...

journal_title：Cancer letters

authors： Ruiz B,Correa P,Fontham ET,Rood JC,Malcom GT,Torrado J,Perez A,Ramakrishnan T,Hunter FM

更新日期：1994-08-15 00:00:00

abstract：:N-ethyl-N-nitrosourea-induced rat gliomas showed a stimulation of cytosolic spermidine N-acetyltransferase activity compared with normal brain, with an increased formation of N1 and N8-acetylspermidine, suggesting the activation of two enzymes acetylating the polyamine in N1 and N8 position, respectively. The enhancem...

journal_title：Cancer letters

authors： Sessa A,Broglia E,Terreni MR,Perin A

更新日期：1994-01-30 00:00:00

abstract：:Protease inhibitors have been shown to be highly effective suppressors of carcinogenesis in both in vivo and in vitro model systems. For example, the soybean derived Bowman Birk inhibitor (BBI) has been shown to inhibit colon carcinogenesis. Although the precise mechanisms by which protease inhibitors suppress carcino...

journal_title：Cancer letters

authors： Habres JM,Billings PC

更新日期：1992-04-15 00:00:00

abstract：:Absent or altered differentiation is one of the major features of cancer cells. Histone deacetylases (HDACs) play a central role in the epigenetic regulation of gene expression. Aberrant activity of HDACs has been documented in several types of cancers, leading to the development of HDAC inhibitors (HDACi) as anti-tum...

journal_title：Cancer letters

authors： Botrugno OA,Santoro F,Minucci S

更新日期：2009-08-08 00:00:00

abstract：:5-FU is commonly used for treatment of various solid tumors including colon carcinoma. We have previously demonstrated that Egr-1 induced by 5-FU enhanced TSP-1 expression in human colon cancer KM12C cells. In this study, a Genechip analysis of KM12C cells treated with 5-FU revealed down-regulation of 924 genes and up...

journal_title：Cancer letters

authors： Zhao HY,Ooyama A,Yamamoto M,Ikeda R,Haraguchi M,Tabata S,Furukawa T,Che XF,Iwashita K,Oka T,Fukushima M,Nakagawa M,Ono M,Kuwano M,Akiyama S

更新日期：2008-10-18 00:00:00

abstract：:cDNA libraries were generated from the prostate gland tissue obtained from a normal donor and from a patient with prostate cancer. Subtractive cDNA cloning was used to identify phenotype-specific cDNA sequences from both normal and cancerous prostate tissue. One clone, pN44, isolated from normal prostate tissue, codes...

journal_title：Cancer letters

authors： Liu AY,Bradner RC,Vessella RL

更新日期：1993-10-15 00:00:00

abstract：:When injected into female NMRI mice tumour necrosis factor-alpha (TNF) produced a dose-related weight loss over the first 24 h, which was accompanied by and directly proportional to a decrease in both food and water intake. Body composition analysis after the first 8 h revealed that the weight loss was associated with...

journal_title：Cancer letters

authors： Mahony SM,Tisdale MJ

更新日期：1989-06-01 00:00:00

abstract：:Gene amplification has been found to be biologically important in cancer. We report a complementary DNA sequence obtained using a subtractive hybridization approach which is frequently and highly amplified in human gliomas. 39/45 (87%) glial tumor specimens (of pathologically low and high grade) revealed increases in ...

journal_title：Cancer letters

authors： Liang BC,Hays L

更新日期：1996-08-02 00:00:00

abstract：:The effect of interferon (IFN)-alpha, beta and gamma on the growth of DHL-4 diffuse large B cell lymphoma cells was studied. IFN-beta significantly inhibited the cell growth, and the effect was stronger than that of IFN-alpha. IFN-gamma did not inhibit the cell growth because of lack of IFN-gamma receptors. IFN-beta c...

journal_title：Cancer letters

authors： Oehadian A,Koide N,Mu MM,Hassan F,Islam S,Yoshida T,Yokochi T

更新日期：2005-07-08 00:00:00

abstract：:Artesunate (ART), a semi-synthetic derivative of artemisinin extracted from the Chinese herb Artemisia annua, is a safe and effective antimalarial drug. ART has now been analyzed for its anti-angiogenic activity in vivo and in vitro. The anti-angiogenic effect in vivo was evaluated on chicken chorioallantoic membrane ...

journal_title：Cancer letters

authors： Huan-huan C,Li-Li Y,Shang-Bin L

更新日期：2004-08-10 00:00:00

abstract：:Pancreatic cancer is a malignant disease without efficient treatment. Improved treatments are urgently needed to enhance or replace chemotherapy. Here we used a small molecular compound LB-100 to assess the effect of pharmacological inhibition of protein phosphatase 2A (PP2A) in combination with doxorubicin on the pro...

journal_title：Cancer letters

authors： Bai X,Zhi X,Zhang Q,Liang F,Chen W,Liang C,Hu Q,Sun X,Zhuang Z,Liang T

更新日期：2014-12-28 00:00:00

abstract：:We analysed the expression of BIRC5 and BIRC5-2B in primary neuroblastoma (NB) tumors and NB model systems. In tumors, overexpression of BIRC5 correlated closely with its isoform BIRC5-2B. Expression of both transcripts was stage-dependent, associated with poor prognosis and with the expression of the transcription fa...

journal_title：Cancer letters

authors： Eckerle I,Muth D,Batzler J,Henrich KO,Lutz W,Fischer M,Witt O,Schwab M,Westermann F

更新日期：2009-11-18 00:00:00

abstract：:The small 25 kDa peptide, neutrophil gelatinase-associated lipocalin (NGAL), first known as an antibacterial factor of natural immunity, and an acute phase protein, is currently one of the most interesting and enigmatic proteins involved in the process of tumor development. The aim of the present review is to point ou...

journal_title：Cancer letters

authors： Bolignano D,Donato V,Lacquaniti A,Fazio MR,Bono C,Coppolino G,Buemi M

更新日期：2010-02-01 00:00:00

abstract：:Our previous studies have shown that norepinephrine induces the migratory activity of human PC-3 prostate, SW 480 colon and MDA-MB-468 breast carcinoma cells. In contrast to these results, we show here that human ES-2 ovarian carcinoma cells have a reduced migratory activity after norepinephrine treatment. This inhibi...

journal_title：Cancer letters

authors： Bastian P,Balcarek A,Altanis C,Strell C,Niggemann B,Zaenker KS,Entschladen F

更新日期：2009-02-18 00:00:00

abstract：:To better understand causative relations of smoking to lung adenocarcinomas, the frequency of loss of heterozygosity (LOH) of all autosomal chromosomes was compared among the three grades of histological differentiation with 119 pulmonary adenocarcinomas (AC) and 41 squamous cell carcinomas (SCC), using Southern blott...

journal_title：Cancer letters

authors： Ishikawa Y,Furuta R,Miyoshi T,Satoh Y,Okumura S,Nakagawa K,Tsuchiya E

更新日期：2002-12-10 00:00:00

abstract：:We have previously shown that transforming growth factor (TGF)-beta up-regulates matrix metalloproteinase (MMP)-2 leading to the induction of oncogenic signaling in preneoplastic MCF10A human breast epithelial cells. The present study investigated the mechanism of transcriptional regulation of MMP-2 by TGF-beta in MCF...

journal_title：Cancer letters

authors： Kim ES,Sohn YW,Moon A

更新日期：2007-07-08 00:00:00

abstract：:The incidence of breast cancer has increased rapidly in recent years and has now become the most common cancer in women in major cities of China. Here, we reviewed the history and progress of breast cancer research in China, including achievements that Chinese scientists have made in basic, translational and clinical ...

journal_title：Cancer letters

authors： Hong W,Dong E

更新日期：2014-08-28 00:00:00

abstract：:The limitations of current chemotherapies have motivated research in developing new treatments. Growing evidence shows that interaction between tumors and their microenvironment, but not tumor cells per se, is the key factor in tumor progression and therefore of obvious scientific interest and therapeutic value. Exoso...

journal_title：Cancer letters

authors： Tang MK,Wong AS

更新日期：2015-10-10 00:00:00

abstract：:The widespread consumption of tea as beverage throughout the world has stimulated interest in the possibility of its use in chemoprevention of cancer. The present set of investigation was carried out to evaluate the anticarcinogenic activity of black tea using lung tumorigenesis model in Swiss albino mice. Diethylnitr...

journal_title：Cancer letters

authors： Shukla Y,Taneja P

更新日期：2002-02-25 00:00:00

abstract：:We investigated the role of the 5-lipoxygenase (5-LOX) pathway of arachidonic acid metabolism in tumour necrosis factor-alpha (TNF-alpha)-induced differentiation of human leukemic HL-60 cells using MK-886, an inhibitor of 5-LOX activating protein. MK-886 augmented cell cycle arrest and differentiation induced by TNF-a...

journal_title：Cancer letters

authors： Stika J,Vondrácek J,Hofmanová J,Simek V,Kozubík A

更新日期：2006-06-18 00:00:00

abstract：:The human myelocytic leukemia cell line HL-60 is a useful model for the study of cellular differentiation. Phorbol 12-myristate 13-acetate (PMA) induces the monocyte/macrophage-like differentiation of HL-60 cells and results in growth arrest, increasing adherence. In PMA-induced differentiation of HL-60 cells, phospho...

journal_title：Cancer letters

authors： Kim MS,Lim WK,Cha JG,An NH,Yoo SJ,Park JH,Kim HM,Lee YM

更新日期：2001-09-28 00:00:00

abstract：:Microphthalmia-associated transcription factor (MITF) is expressed in melanomas and has a critical role in melanocyte development and transformation. Because inhibition of MITF inhibits cell growth in melanoma, MITF is a potential therapeutic target molecule. Here, we report the identification of CH6868398, which has ...

journal_title：Cancer letters

authors： Aida S,Sonobe Y,Tanimura H,Oikawa N,Yuhki M,Sakamoto H,Mizuno T

更新日期：2017-11-28 00:00:00

abstract：:Homeobox genes, involved in embryonic development and tissues homeostasis in adults, are often deregulated in cancer, but their relevance in pathology is far from being fully elucidated. In colon cancers, we report that the homeoproteins HoxB7 and Cdx2 exhibit different heterogeneous patterns, Cdx2 being localized in ...

journal_title：Cancer letters

authors： Soret C,Martin E,Duluc I,Dantzer F,Vanier M,Gross I,Freund JN,Domon-Dell C

更新日期：2016-05-01 00:00:00