mTOR inhibition by everolimus counteracts VEGF induction by sunitinib and improves anti-tumor activity against gastric cancer in vivo.

Abstract:

:VEGF receptor blockage has been reported to increase serum VEGF. We hypothesized that mTOR inhibition by everolimus counteracts VEGF induction by sunitinib resulting in an improved anti-tumor activity of sunitinib. In vitro, sunitinib in combination with everolimus did not outperform the respective monotherapies. In vivo, monotherapies reduced tumor growth by 60%, whereas the combination of sunitinib and everolimus led to an almost complete tumor growth inhibition. This superior anti-tumor activity coincided with attenuation of VEGF peaks. In conclusion mTOR inhibition by everolimus counteracts VEGF induction by sunitinib and results in significant reduction of tumor burden and long-lasting tumor growth control.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Fuereder T,Jaeger-Lansky A,Hoeflmayer D,Preusser M,Strommer S,Cejka D,Koehrer S,Crevenna R,Wacheck V

doi

10.1016/j.canlet.2010.04.015

subject

Has Abstract

pub_date

2010-10-28 00:00:00

pages

249-56

issue

2

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(10)00219-3

journal_volume

296

pub_type

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