Abstract:
:VEGF receptor blockage has been reported to increase serum VEGF. We hypothesized that mTOR inhibition by everolimus counteracts VEGF induction by sunitinib resulting in an improved anti-tumor activity of sunitinib. In vitro, sunitinib in combination with everolimus did not outperform the respective monotherapies. In vivo, monotherapies reduced tumor growth by 60%, whereas the combination of sunitinib and everolimus led to an almost complete tumor growth inhibition. This superior anti-tumor activity coincided with attenuation of VEGF peaks. In conclusion mTOR inhibition by everolimus counteracts VEGF induction by sunitinib and results in significant reduction of tumor burden and long-lasting tumor growth control.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Fuereder T,Jaeger-Lansky A,Hoeflmayer D,Preusser M,Strommer S,Cejka D,Koehrer S,Crevenna R,Wacheck Vdoi
10.1016/j.canlet.2010.04.015subject
Has Abstractpub_date
2010-10-28 00:00:00pages
249-56issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(10)00219-3journal_volume
296pub_type
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