Interferon (IFN)-beta induces apoptotic cell death in DHL-4 diffuse large B cell lymphoma cells through tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).

abstract：:Sperm protein 17 (Sp17) is a highly antigenic, testes-specific protein whose known function is to bind sperm to the zona pellucida. However, the Sp17 gene has been recently detected in normal non-testes tissues and malignant neoplasias. As the role of Sp17 in non-testes tissues is unknown, the characterization of the ...

journal_title：Cancer letters

authors： De Jong A,Buchli R,Robbins D

更新日期：2002-12-05 00:00:00

abstract：:Under most circumstances, hepatitis B virus (HBV) is noncytopathic. However, hepatocellular regeneration that accompanies each bout of hepatitis appears to be associated with increased integration of HBV DNA fragments expressing the virus encoded hepatitis B x antigen (HBxAg). Intrahepatic HBxAg staining correlates wi...

journal_title：Cancer letters

authors： Feitelson MA,Reis HM,Tufan NL,Sun B,Pan J,Lian Z

更新日期：2009-12-01 00:00:00

abstract：:HGT cells are a human gastric cell line derived from a tumour of the stomach. We have investigated the effects of lipoxygenase and cyclooxygenase metabolism inhibitors on HGT cell proliferation, on fatty acid composition of HGT cells and on the incorporation and distribution of arachidonic acid (AA) in HGT lipids. The...

journal_title：Cancer letters

authors： Denizot Y,Najid A,Rigaud M

更新日期：1993-09-15 00:00:00

abstract：:The ability of a cancer cell to metastasis to a distant site is partly dependent on the secretion of matrix degrading enzymes. The lysosomal cysteine proteinases, cathepsins B and L, have been shown to be secreted by a number of cancer cells and have been implicated in metastasis. Cathepsins B and L are regulated by a...

journal_title：Cancer letters

authors： Colella R,Goodwyn E,Gopal P

更新日期：2002-11-28 00:00:00

abstract：:Analysis of the loss of heterozygosity (LOH) detected by polymerase chain reaction techniques using 18 polymorphic markers localized to chromosomes 3p, 5, 17, and 18q in 40 Hong Kong Chinese esophageal squamous cell carcinoma (ESC) patients showed that multiple alterations on several chromosomes are involved in ESC de...

journal_title：Cancer letters

authors： Ko JM,Wong CP,Tang CM,Lau KW,Lung ML

更新日期：2001-09-20 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal types of cancer with poor prognosis. Despite extensive efforts, the current treatment methods have limited success. Therefore, novel therapeutic approaches are required. The pancreatic tumor microenvironment is rich in growth factors and inflammato...

journal_title：Cancer letters

authors： Roshani R,McCarthy F,Hagemann T

更新日期：2014-04-10 00:00:00

abstract：:We planned to determine the relationship between angiogenesis and p53 mutational status in advanced-stage epithelial ovarian cancer. Using 190 tumor samples from patients with stage III and IV ovarian cancer we performed p53 sequencing, immunohistochemistry, and CD31 microvessel density (MVD) determination. MVD was el...

journal_title：Cancer letters

authors： Nadkarni NJ,Geest KD,Neff T,Young BD,Bender DP,Ahmed A,Smith BJ,Button A,Goodheart MJ

更新日期：2013-04-30 00:00:00

abstract：:Repeated application of the tumor promoter 12-O-tetradecanoyl phorbol-13-acetate (TPA) to the skin of mice previously treated with an initiating dose of the carcinogen 7,12-dimethylbenz[a] anthracene has been shown to lead to an increased incidence of papilloma. The studies presented here describe a modified murine tw...

journal_title：Cancer letters

authors： Devens BH,Lundak RL,Byus CV

更新日期：1984-01-01 00:00:00

abstract：:Previously, we have shown that simian virus 40 (SV40) T antigen can directly cause apoptosis in immortalized human epithelial cells under normal growth conditions. In this study, we further characterized the mechanism of T-antigen-mediated apoptosis involving p53 and whether T antigen can suppress erbB2/neu gene expre...

journal_title：Cancer letters

authors： Wang CH,Chen YL,Tsao YP,Chen SL

更新日期：1999-03-22 00:00:00

abstract：:Immunogenic, methylcholanthrene-induced sarcomas failed to elicit the production of rapidly cytolytic T lymphocytes in syngeneic mice, although they did elicit the production of more slowly cytotoxic cells. They were, however, susceptible to attack by cytolytic T cells from allo-immune mice and, if infected with ectro...

journal_title：Cancer letters

authors： Nelson DS,Hopper KE,Blanden RV,Gardner ID,Kearney R

更新日期：1978-08-01 00:00:00

abstract：:The striking differences in the natural history of clinical subgroups of neuroblastoma (NB), and the evolving therapeutic approaches for each, makes it imperative for prognostic markers to be reevaluated within individual clinical categories. At least one third of NB cases present without distant metastasis and cytoto...

journal_title：Cancer letters

authors： Mora J,Gerald WL,Cheung NK

更新日期：2003-07-18 00:00:00

abstract：:Avemar (MSC) is a nontoxic fermented wheat germ extract demonstrated to significantly improve the survival rate in patients suffering from various malignancies. We investigated its effects in human HL-60 promyelocytic leukemia cells. After 24, 48, and 72 h of incubation, Avemar inhibited the growth of HL-60 cells with...

journal_title：Cancer letters

authors： Saiko P,Ozsvar-Kozma M,Madlener S,Bernhaus A,Lackner A,Grusch M,Horvath Z,Krupitza G,Jaeger W,Ammer K,Fritzer-Szekeres M,Szekeres T

更新日期：2007-06-08 00:00:00

abstract：:HER2 positive breast cancers have been shown to have a greater propensity to metastasise to the brain. This may be due to several reasons, including the creation of a "sanctuary-site" for tumour in the brain following trastuzumab therapy. Elucidating the mechanism of this phenomenon may aid the prevention or intervent...

journal_title：Cancer letters

authors： Patil A,Sherbet GV

更新日期：2015-03-28 00:00:00

abstract：:The influence of the carcinogen 2-acetylaminofluorene (2AAF) administration on splenic natural killer (NK) cell function in two strains of rats has been examined and compared with that of the non-carcinogenic analogue 4-acetylaminofluorene (4AAF). In both strains it was observed that daily exposure to 25 mg kg-1 2AAF ...

journal_title：Cancer letters

authors： Kimber I,Griffin AC,Jones K

更新日期：1986-01-01 00:00:00

abstract：:The heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a nucleic acid-binding protein that serves as a docking platform integrating transduction pathways to nucleic acid -directed processes. Recently, this protein has emerged as an important player in carcinogenesis process. HnRNP K is overexpressed in several hum...

journal_title：Cancer letters

authors： Barboro P,Ferrari N,Balbi C

更新日期：2014-10-01 00:00:00

abstract：:Monoclonal antibodies were produced and characterized in order to allow the monitoring of the urinary excretion of six modified nucleosides. The specificity of each antibody was determined and competitive solid-phase enzyme-linked immunoassays were designed, the sensitivity of which lay in the pmol range. Detection an...

journal_title：Cancer letters

authors： Reynaud C,Bruno C,Boullanger P,Grange J,Barbesti S,Niveleau A

更新日期：1992-01-31 00:00:00

abstract：:Resveratrol (trans-3,4',5-trihydroxystilbene) is a natural antioxidant found in plants, such as grapes, that studies suggest has cancer chemopreventive activity. We investigated the effects of resveratrol on DNA binding via esterification reactions with 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OH-PhIP...

journal_title：Cancer letters

authors： Dubuisson JG,Dyess DL,Gaubatz JW

更新日期：2002-08-08 00:00:00

abstract：:This study investigated the role of miR-206 in estrogen receptor-α (ERα)-positive endometrial endometrioid adenocarcinoma (EEC). We profiled miR-206 expression in 30 EEC clinical samples using qRT-PCR, and explored its relationship with ERα and clinical parameters. A luciferase reporter assay assessed the ERα targetin...

journal_title：Cancer letters

authors： Chen X,Yan Q,Li S,Zhou L,Yang H,Yang Y,Liu X,Wan X

更新日期：2012-01-01 00:00:00

abstract：:Gene delivery vectors, including adenovirus (Ad) and adeno-associated virus (AAV), are inefficient and non-selective for cancer due to low levels of viral receptors with high levels on other tissues, including liver. We tested Ads and AAVs with the SIGYPLP-targeting peptide inserted into virus capsids for transduction...

journal_title：Cancer letters

authors： Nicklin SA,Dishart KL,Buening H,Reynolds PN,Hallek M,Nemerow GR,Von Seggern DJ,Baker AH

更新日期：2003-11-25 00:00:00

abstract：:Diet-induced changes in serum cholesterol levels and their relationship to mammary carcinogenesis initiated by 7,12-dimethylbenz[a]anthracene (DMBA) were studied in female Sprague-Dawley rats. DMBA was given to rats subjected to 3 dietary treatments: (1) a semipurified, cholesterol-free diet (SP); (2) the same diet wi...

journal_title：Cancer letters

authors： Klurfeld DM,Kritchevsky D

更新日期：1981-12-01 00:00:00

abstract：:The identification of frameshift mutations in the coding region of the bax gene in Western cases of hereditary non-polyposis colorectal cancer provided evidence that the disease could be caused by the disruption of a tumor suppressor gene associated with microsatellite instability. In order to determine whether this o...

journal_title：Cancer letters

authors： Sakakibara T,Nakamura T,Yamamoto M,Matsuo M

更新日期：1998-02-27 00:00:00

abstract：:Gene methylation is an important molecular event in prostate carcinogenesis that may have diagnostic and prognostic significance. We evaluated the methylation status of eight genes implicated in prostate carcinogenesis. DNA was extracted from archived paraffin-embedded tumor blocks from 90 prostate cancer patients. Ge...

journal_title：Cancer letters

authors： Woodson K,Hanson J,Tangrea J

更新日期：2004-03-18 00:00:00

abstract：:The present study aims to evaluate the antitumor activity of silybin nanosuspension on human prostatic carcinoma PC-3 cell line in vitro. Silybin nanosuspension was prepared by the high pressure homogenization (HPH) method. MTT assay, observation of morphological changes and apoptotic body showed that silybin nanosusp...

journal_title：Cancer letters

authors： Zheng D,Wang Y,Zhang D,Liu Z,Duan C,Jia L,Wang F,Liu Y,Liu G,Hao L,Zhang Q

更新日期：2011-08-28 00:00:00

abstract：:We studied the effects of a lignan, hydroxymatairesinol (HMR), and rye bran on intestinal tumor development in adenomatous polyposis colimultiple intestinal neoplasia (Apc)(Min) mice. HMR showed a strong chemopreventive effect in this animal model. The mean number of adenomas in the small intestine was significantly l...

journal_title：Cancer letters

authors： Oikannen SI,Pajari AM,Mutanen M

更新日期：2000-10-31 00:00:00

abstract：:The fruiting body of Antrodia camphorata is well known in Taiwan as a traditional medicine for treating cancer and inflammation. The purpose of this study was to evaluate the apoptotic effects of ethylacetate extract from A. camphorata (EAC) fruiting bodies in two human liver cancer cell lines, Hep G2 and PLC/PRF/5. T...

journal_title：Cancer letters

authors： Hsu YL,Kuo YC,Kuo PL,Ng LT,Kuo YH,Lin CC

更新日期：2005-04-18 00:00:00

abstract：:The Chinese Glioma Cooperative Group (CGCG) Guideline Panel for adult diffuse gliomas provided recommendations for diagnostic and therapeutic procedures. The Panel covered all fields of expertise in neuro-oncology, i.e. neurosurgeons, neurologists, neuropathologists, neuroradiologists, radiation and medical oncologist...

journal_title：Cancer letters

authors： Jiang T,Mao Y,Ma W,Mao Q,You Y,Yang X,Jiang C,Kang C,Li X,Chen L,Qiu X,Wang W,Li W,Yao Y,Li S,Li S,Wu A,Sai K,Bai H,Li G,Chen B,Yao K,Wei X,Liu X,Zhang Z,Dai Y,Lv S,Wang L,Lin Z,Dong J,Xu G,M

更新日期：2016-06-01 00:00:00

abstract：:We describe an optimized systematic screen of known kinases using osteosarcoma cell lines (KHOS and U-2OS) and a lentiviral-based short hairpin RNA (shRNA) human kinase library. CellTiter 96(R)AQueous One Solution Cell Proliferation Assay was used to measure cell growth and survival. We identified several kinases, inc...

journal_title：Cancer letters

authors： Duan Z,Ji D,Weinstein EJ,Liu X,Susa M,Choy E,Yang C,Mankin H,Hornicek FJ

更新日期：2010-07-28 00:00:00

abstract：:It has been shown that acquisition of epithelial-mesenchymal transition (EMT) and induction of cancer stem cell (CSC)-like properties contribute to metastasis of cancers in many studies; however, the molecular mechanisms underlying EMT and CSC phenotypes in liver cancer cells remain to be elucidated. MiR-155 is an imp...

journal_title：Cancer letters

authors： Liu F,Kong X,Lv L,Gao J

更新日期：2015-04-10 00:00:00

abstract：:DDX1, a gene mapping to the 2p24 region, has been observed to be co-amplified with MYCN in neuroblastoma. Co-amplification of the DDX1 gene is a consequence of the short physical distance between the two genes. Recently, it has been found that neuroblastoma cells can show a low increase in MYCN gene copy number, defin...

journal_title：Cancer letters

authors： Defferrari R,Tonini GP,Conte M,Papio F,Sementa AR,Valent A,Schena F,Perri P,Mazzocco K

更新日期：2007-10-18 00:00:00

abstract：:Selenium-dependent (Se-GSH-Px), selenium-independent (non-Se-GSH-Px) glutathione peroxidase and glutathione reductase (GSSG-Rx) activities have been determined in cancerous and non-cancerous human adult kidney. Large inter-individual variation in the activities of all enzymes tested were found in both tumour and non-t...

journal_title：Cancer letters

authors： Di Ilio C,Sacchetta P,Angelucci S,Zezza A,Tenaglia R,Aceto A

更新日期：1995-05-04 00:00:00