Abstract:
:The present study aims to evaluate the antitumor activity of silybin nanosuspension on human prostatic carcinoma PC-3 cell line in vitro. Silybin nanosuspension was prepared by the high pressure homogenization (HPH) method. MTT assay, observation of morphological changes and apoptotic body showed that silybin nanosuspension could significantly enhance the in vitro cytotoxicity against PC-3 cells compared to the silybin solution. Flow cytometric (FCM) analysis demonstrated that silybin nanosuspension induced G1 cycle arrest and apoptosis in PC-3 cells. Thereby, the overall results suggest that the silybin nanosuspension represents a potential source of medicine for the treatment of human prostate cancer.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Zheng D,Wang Y,Zhang D,Liu Z,Duan C,Jia L,Wang F,Liu Y,Liu G,Hao L,Zhang Qdoi
10.1016/j.canlet.2011.03.028subject
Has Abstractpub_date
2011-08-28 00:00:00pages
158-64issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(11)00189-3journal_volume
307pub_type
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