Abstract:
:Diet-induced changes in serum cholesterol levels and their relationship to mammary carcinogenesis initiated by 7,12-dimethylbenz[a]anthracene (DMBA) were studied in female Sprague-Dawley rats. DMBA was given to rats subjected to 3 dietary treatments: (1) a semipurified, cholesterol-free diet (SP); (2) the same diet with 1.5% cholesterol and 0.5% bile salts added (CB); (3) diet CB, until administration of DMBA and then switched to diet SP. Tumor yield per rat was increased in rats fed diet CB, but incidence and tumor size were similar among all 3 groups. Rats maintained on diet SP alone had a higher percentage of histologically benign tumors. Hypercholesterolemia of dietary origin appears to enhance slightly chemical carcinogenesis in this model.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Klurfeld DM,Kritchevsky Ddoi
10.1016/0304-3835(81)90154-3subject
Has Abstractpub_date
1981-12-01 00:00:00pages
273-8issue
3eissn
0304-3835issn
1872-7980pii
0304-3835(81)90154-3journal_volume
14pub_type
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