Abstract:
:Inhibition of 5-Lox induces apoptosis in prostate cancer cells by inactivating PKCε which is prevented by 5-oxoETE, and activators of PKCε prevent 5-Lox inhibition-induced apoptosis, suggesting that 5-Lox metabolites exert survival signaling via PKCε. However, mechanisms by which 5-Lox metabolites activate PKCε are not understood yet. We found that prostate cancer cells express high levels of OXER1, a G protein-coupled 5-oxoETE receptor, which delivers signal by generating diacyl-glycerol through phospholipase C-beta. Interestingly, we found that U73122, an inhibitor of PLC-beta, interrupts the apoptosis-preventing effect of 5-oxoETE, and exogenous diacyl-glycerol effectively prevents 5-Lox inhibition-induced apoptosis, suggesting that 5-oxoETE signals via OXER1 to promote prostate cancer cell survival.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Sarveswaran S,Ghosh Jdoi
10.1016/j.canlet.2013.04.027subject
Has Abstractpub_date
2013-08-09 00:00:00pages
185-95issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(13)00361-3journal_volume
336pub_type
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