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Apoptosis induced by the sonomechanical effects of low intensity pulsed ultrasound in a human leukemia cell line.

Abstract：

:To obtain an optimal condition for ultrasound (US)-induced apoptosis that could be useful for cancer therapy, we applied low intensity pulsed US to sonicate U937 cells in vitro. Cells were then incubated at different time intervals before measuring apoptosis. The apoptosis was assessed by DNA fragmentation and phosphatidylserine externalization. The pattern of the decrease in mitochondrial membrane potential was determined by flow cytometry. Optimal apoptosis (70.0+/-13.8%) with minimal lysis was attained with 1 MHz ultrasound 0.3 W/cm2, 10% duty factor at 100 Hz for 1 min) at 12 h after sonication. Lack of US-induced free radical detection and absence of Heme oxygenase-1, an intracellular oxidative stress marker, up-regulation in cells, suggest that sonomechanical, not sonochemical, effects are the main mechanism involved.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Feril LB Jr,Kondo T,Cui ZG,Tabuchi Y,Zhao QL,Ando H,Misaki T,Yoshikawa H,Umemura S

doi

10.1016/j.canlet.2004.08.034

keywords:

subject

Has Abstract

pub_date

2005-04-28 00:00:00

pages

145-52

issue

2

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(04)00704-9

journal_volume

221

pub_type

杂志文章

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