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Acquisition of anoikis resistance reveals a synoikis-like survival style in BEL7402 hepatoma cells.

Abstract：

:Resistance to anoikis is a hallmark of human malignancies. Our results showed that hepatoma cells resisted anoikis by non-proliferation, non-apoptosis and cell cycle arrest which were termed synoikis-like. These synoikis-like cells are more resistant to extracellular stimuli and could spontaneously attach and proliferate again under suitable conditions, which indicate a reversible property of these cells. Microarray expression profile reveals the change of molecules involved in the synoikis-like hepatoma cells and our data indicated that ANGPTL4 contributed to anoikis resistance of hepatoma cells. These results demonstrated that hepatoma cells might resist anoikis through a synoikis-like survival style, which may facilitate tumor metastasis.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Zhang Z,Cao L,Li J,Liang X,Liu Y,Liu H,Du J,Qu Z,Cui M,Liu S,Gao L,Ma C,Zhang L,Han L,Sun W

doi

10.1016/j.canlet.2008.03.010

subject

Has Abstract

pub_date

2008-08-18 00:00:00

pages

106-15

issue

1

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(08)00201-2

journal_volume

267

pub_type

杂志文章

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