Abstract:
:The appearance of apoptosis has been used as an index of carcinogen-induced damage incurred by the intestinal epithelium. Here we report that the cytotoxic response elicited by gamma radiation in the duodenal and colonic epithelium of the mouse is markedly affected by the time of day at which the animals are irradiated or sampled. The diurnal pattern in radiosensitivity of the crypt cells, as measured by the appearance of apoptosis is reflective of circadian rhythms in mouse intestinal cells. Circadian effects should therefore be considered when interpreting apoptosis data obtained at one time point only or when comparing data obtained at different times of the day.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Duncan AM,Ronen A,Blakey DHdoi
10.1016/0304-3835(83)90203-3subject
Has Abstractpub_date
1983-12-01 00:00:00pages
163-6issue
2eissn
0304-3835issn
1872-7980pii
0304-3835(83)90203-3journal_volume
21pub_type
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