当前位置： SCI文献检索 > CANCER LETTERS期刊下所有文献 > Antipromoting effects of 5-lipoxygenase inhibitors, 3-nitro-2,4,6- trihydroxybenzamide derivatives, on TPA-promoted transformation in BALB 3T3 cells.

Antipromoting effects of 5-lipoxygenase inhibitors, 3-nitro-2,4,6- trihydroxybenzamide derivatives, on TPA-promoted transformation in BALB 3T3 cells.

Abstract：

:In order to discover the role in the promotion process of 5-lipoxygenase (5-LO), a key enzyme in the arachidonate cascade, the antipromoting effects of the 5-LO inhibiting 3-nitro-2,4,6-trihydroxybenzamide (NTB) derivatives were studied in a two-stage transformation assay system using BALB 3T3 cells. All compounds inhibited TPA-promoted transformation in a dose-dependent manner. Most of them achieved a 70-80% inhibition. Good correlations were observed between the inhibition of TPA-promoted transformation and that of 5-LO. These results indicate that 5-LO plays an important role in the promotion stage of the transformation of BALB 3T3 cells.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Semba M,Honda I,Shibagaki M,Nishi Y

doi

10.1016/0304-3835(93)90097-s

subject

Has Abstract

pub_date

1993-07-30 00:00:00

pages

57-60

issue

1-3

eissn

0304-3835

issn

1872-7980

pii

0304-3835(93)90097-S

journal_volume

71

pub_type

杂志文章

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