Biomimetic models to examine microenvironmental regulation of glioblastoma stem cells.

abstract：:The effect of glucocorticoids on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inhibition of gap-junctional intercellular communication (GJIC) and morphological transformation in Syrian hamster embryo (SHE) cells was examined. Fluocinolone acetonide (FA) and dexamethasone (DEX) almost completely suppressed the ef...

journal_title：Cancer letters

authors： Roseng LE,Rivedal E

更新日期：1993-08-16 00:00:00

abstract：:Increasing evidence suggests that DLL4 (Delta-like 4)-Notch signaling plays a critical role in cell fate determination and differentiation in tissues. Blocking DLL4-Notch signaling results in inhibition of tumor growth, which is associated with increased nonfunctional vessels and poor perfusion in the tumor. We succes...

journal_title：Cancer letters

authors： Xu Z,Wang Z,Jia X,Wang L,Chen Z,Wang S,Wang M,Zhang J,Wu M

更新日期：2016-03-01 00:00:00

abstract：:A cell line partially resistant to dimethylsulfoxide (DMSO) was derived from the HL-60 cell line. Cycloleucine, theophylline, sodium butyrate and elevated levels of DMSO were found to induce myeloid differentiation in this cell line while TPA induced monocytic differentiation. The levels of myc RNA and the genomic str...

journal_title：Cancer letters

authors： Grosso LE,Pitot HC

更新日期：1984-02-01 00:00:00

abstract：:A novel iron chelator, HDp44mT, has been reported to have potent anti-proliferative effects on cancer cells; however, the underlying mechanism of action is not well understood. In this study, we characterized the cytotoxic effect of HDp44mT in a chemo- and radio-resistant cell line (PC-3) of prostatic cancer origin. T...

journal_title：Cancer letters

authors： Tian J,Peehl DM,Zheng W,Knox SJ

更新日期：2010-12-08 00:00:00

abstract：:A 1-week treatment with the hepatocarcinogen beta-blocker DL-1-(2-nitro-3-methyl-phenoxy)-3-tert-butylamino-propan-2-ol (ZAMI 1305) induces the appearance of preneoplastic liver lesions--oval cell hyperplasia, basophilic and gamma-glutamyltranspeptidase positive (GGT+) foci--in female Wistar rats, as evidenced by the ...

journal_title：Cancer letters

authors： Zavanella T,Presta M,Braga G,Dimito E,Mazzocchi C,Ziliani S,Ragnotti G

更新日期：1984-11-01 00:00:00

abstract：:Effects of the green tea catechins (GTCs) on the late promotion or progression stage of mammary gland carcinogenesis were examined in female Sprague-Dawley (SD) rats pretreated with 7,12-dimethylbenz(a)anthracene (DMBA). A total of 84 7-week-old rats received a 50 mg/kg body weight intra-gastric dose of DMBA, and star...

journal_title：Cancer letters

authors： Hirose M,Mizoguchi Y,Yaono M,Tanaka H,Yamaguchi T,Shirai T

更新日期：1997-01-30 00:00:00

abstract：:p66(Shc), one of the SHC1 gene encoding proteins, promotes cell death and reports cell anchorage status, mediating anoikis in vitro and functioning as a metastasis suppressor in vivo. However, very little is known about p66(Shc) gene regulation in cancer cells. Here, we show that methylation of a specific CpG site in ...

journal_title：Cancer letters

authors： Du W,Jiang Y,Zheng Z,Zhang Z,Chen N,Ma Z,Yao Z,Terada L,Liu Z

更新日期：2013-08-28 00:00:00

abstract：:We describe an optimized systematic screen of known kinases using osteosarcoma cell lines (KHOS and U-2OS) and a lentiviral-based short hairpin RNA (shRNA) human kinase library. CellTiter 96(R)AQueous One Solution Cell Proliferation Assay was used to measure cell growth and survival. We identified several kinases, inc...

journal_title：Cancer letters

authors： Duan Z,Ji D,Weinstein EJ,Liu X,Susa M,Choy E,Yang C,Mankin H,Hornicek FJ

更新日期：2010-07-28 00:00:00

abstract：:Artesunate (ART), a semi-synthetic derivative of artemisinin extracted from the Chinese herb Artemisia annua, is a safe and effective antimalarial drug. ART has now been analyzed for its anti-angiogenic activity in vivo and in vitro. The anti-angiogenic effect in vivo was evaluated on chicken chorioallantoic membrane ...

journal_title：Cancer letters

authors： Huan-huan C,Li-Li Y,Shang-Bin L

更新日期：2004-08-10 00:00:00

abstract：:Serial determinations of urinary biopterin were performed in rats during the development of lung tumors induced by radon inhalation and 5,6-benzonaphtoflavone administration. A striking increase in biopterin levels was observed in animals which developed single or multiple epidermoid carcinoma of the lung and this inc...

journal_title：Cancer letters

authors： Mura P,Morlier JP,Barriere M,Bredon P,Papet Y,Chameaud J

更新日期：1990-10-08 00:00:00

abstract：BACKGROUND AND AIMS:Understanding the molecular pathogenesis of hepatocellular carcinoma (HCC) is essential to identify therapeutic targets. A hepatitis B virus (HBV) related double transgenic murine model was developed. METHODS:Liver specific expression of HBV X protein (HBx) and insulin receptor substrate 1 (IRS1) w...

journal_title：Cancer letters

authors： Chung W,Kim M,de la Monte S,Longato L,Carlson R,Slagle BL,Dong X,Wands JR

更新日期：2016-01-01 00:00:00

abstract：:Radiofrequency ablation (RFA) is widely accepted as a first-line interventional oncology approach for hepatocellular carcinoma (HCC) and has the advantages of high treatment efficacy and low complication risk. Local control rates equivalent to hepatic resection can be reached by RFA alone when treating small HCCs (<2 ...

journal_title：Cancer letters

authors： Chen L,Sun J,Yang X

更新日期：2016-01-01 00:00:00

abstract：:We reported that poor prognoses of hepatocellular carcinoma (HCC) patients after radiofrequency ablation (RFA) are owing to up-regulation of expression of hypoxia-inducible factor-1 and epithelial cell adhesion molecule. We investigated aggressive progression in residual liver tumors (RLTs) after RFA to focus on expre...

journal_title：Cancer letters

authors： Iwahashi S,Shimada M,Utsunomiya T,Imura S,Morine Y,Ikemoto T,Takasu C,Saito Y,Yamada S

更新日期：2016-05-28 00:00:00

abstract：:This aim of this study was to measure the typical free radical-induced products of DNA bases in cellular DNA of cervical cancer tissues directly irradiated by applying brachytherapy to the patients. Significant increases in the amounts of modified bases over the control level were observed in the samples isolated afte...

journal_title：Cancer letters

authors： Foksinski M,Jaruga P,Makarewicz R,Olinski R

更新日期：1998-10-23 00:00:00

abstract：:Cancer stem cells are known for their inherent resistance to therapy. Here we investigated whether normal stem cells with acquired resistance to stress can be used to identify novel markers of cancer stem cells. For this, we generated a human embryonic stem cell line resistant to Trichostatin A and analyzed changes in...

journal_title：Cancer letters

authors： Mousa SA,Sudha T,Dyskin E,Dier U,Gallati C,Hanko C,Chittur SV,Rebbaa A

更新日期：2010-03-28 00:00:00

abstract：:Associations between lung cancer risk and common polymorphisms in the DNA repair genes xeroderma pigmentosum complementation group D (XPD), X-ray repair cross-complementing group 1 (XRCC1), XRCC3 and apurinic/apyrimidinic endonuclease/redox factor 1 were examined within a randomized clinical trial designed to determin...

journal_title：Cancer letters

authors： Misra RR,Ratnasinghe D,Tangrea JA,Virtamo J,Andersen MR,Barrett M,Taylor PR,Albanes D

更新日期：2003-03-10 00:00:00

abstract：:A variety of metal-binding compounds have been found to exert anti-cancer activity. We postulated that N-acetylcysteine (NAC), which is a membrane-permeable metal-binding compound, might have anti-cancer activity in the presence of metals. We found that NAC/Cu(II) significantly alters growth and induces apoptosis in h...

journal_title：Cancer letters

authors： Zheng J,Lou JR,Zhang XX,Benbrook DM,Hanigan MH,Lind SE,Ding WQ

更新日期：2010-12-08 00:00:00

abstract：:We investigated the relationship between ErbB-2 and HLA in order to clarify the clinical and genetic factors related to Japanese patients with lung cancer. Thirty-nine of the 73 lung cancer patients (53.4%) had elevated levels of ErbB-2. Only seven of 23 (30. 4%) patients with small cell carcinoma had elevated ErbB-2 ...

journal_title：Cancer letters

authors： Yoshimura C,Nomura S,Yamaoka M,Ohtani T,Matsuzakiz T,Yamaguchi K,Fukuharal S

更新日期：2000-04-28 00:00:00

abstract：:The rate and extent of metastasis by prostate adenocarcinoma-III cells was enhanced in Lobund-Wistar rats by administration of immune-suppressive cyclosporine A. PA-III cells spread from the subcutaneous PA-III-derived tumor, through ipsilateral lymph nodes, to the lungs in which they developed secondary tumors. Swoll...

journal_title：Cancer letters

authors： Pollard M

更新日期：1997-01-01 00:00:00

abstract：:Standard chemotherapy for pancreatic ductal adenocarcinoma (PDAC), nab-paclitaxel (NPT) plus gemcitabine (Gem), has led to an average survival of 8.5 months. Presently, no therapeutics exist that effectively target the KRAS oncogene, activated in 95% of PDACs, but alternative strategies focus on inhibition of downstre...

journal_title：Cancer letters

authors： Awasthi N,Kronenberger D,Stefaniak A,Hassan MS,von Holzen U,Schwarz MA,Schwarz RE

更新日期：2019-09-10 00:00:00

abstract：:Ashwagandha, also called as "Queen of Ayurveda" and "Indian ginseng", is a commonly used plant in Indian traditional medicine, Ayurveda. Its roots have been used as herb remedy to treat a variety of ailments and to promote general wellness. However, scientific evidence to its effects is limited to only a small number ...

journal_title：Cancer letters

authors： Widodo N,Takagi Y,Shrestha BG,Ishii T,Kaul SC,Wadhwa R

更新日期：2008-04-08 00:00:00

abstract：:The study describes the kinetics of demethylation of mononitrosocaffeidine (MNC), a new asymmetric N-nitrosamine derived from caffeine. The demethylation of its precursor compound caffeidine was also studied. The results presented here suggest (a) that liver microsomes from fasted rats preferentially demethylate the N...

journal_title：Cancer letters

authors： Razdan R,Frei E,Spiegelhalder B,Siddiqi M

更新日期：1994-04-29 00:00:00

abstract：:V600E being the most common mutation in BRAF, leads to constitutive activation of the MAPK signaling pathway. The majority of V600E BRAF positive melanoma patients treated with the BRAF inhibitor vemurafenib showed initial good clinical responses but relapsed due to acquired resistance to the drug. The aim of the pres...

journal_title：Cancer letters

authors： Zubrilov I,Sagi-Assif O,Izraely S,Meshel T,Ben-Menahem S,Ginat R,Pasmanik-Chor M,Nahmias C,Couraud PO,Hoon DS,Witz IP

更新日期：2015-05-28 00:00:00

abstract：:Consumption of false morel (Gyromitra esculenta Fr.) has been associated not only with acute poisoning, but also with a carcinogenic risk. The hydrolysis of acetaldehyde-N-methyl-N-formylhydrazone (gyromitrin, the main toxic component of false morel) results in the formation of the methylating agents N-methyl-N-formyl...

journal_title：Cancer letters

authors： Bergman K,Hellenäs KE

更新日期：1992-01-10 00:00:00

abstract：:Chimeric antigen receptor (CAR) T cell therapy is one of the most promising immunotherapies in the past decade. It brings hope for cure to patients with previously refractory hematological malignancies. However, when translating this strategy into non-hematologic malignancies, the antitumor activity from multiple clin...

journal_title：Cancer letters

authors： Tang XY,Ding YS,Zhou T,Wang X,Yang Y

更新日期：2021-01-19 00:00:00

abstract：:Epigenetic modification of miR-429 can manipulate liver T-ICs via targeting the RBBP4/E2F1/Oct4 axis, which might be crucial for hepatocarcinogenesis. However, whether miR-429 plays a role in regulating metastasis of hepatocellular carcinoma is still unclear. Using quantitative methylation analysis and real-time PCR, ...

journal_title：Cancer letters

authors： Tang J,Li L,Huang W,Sui C,Yang Y,Lin X,Hou G,Chen X,Fu J,Yuan S,Li S,Wen W,Tang S,Cao D,Wu M,Chen L,Wang H

更新日期：2015-08-01 00:00:00

abstract：:Increasing evidence points to a fundamental role for cancer stem cells (CSC) in the initiation and propagation of many tumors. As such, in the context of glioblastoma multiforme (GBM), the development of treatment strategies specifically targeted towards CSC-like populations may hold significant therapeutic promise. T...

journal_title：Cancer letters

authors： Ehtesham M,Mapara KY,Stevenson CB,Thompson RC

更新日期：2009-02-18 00:00:00

abstract：:We investigated the role of the 5-lipoxygenase (5-LOX) pathway of arachidonic acid metabolism in tumour necrosis factor-alpha (TNF-alpha)-induced differentiation of human leukemic HL-60 cells using MK-886, an inhibitor of 5-LOX activating protein. MK-886 augmented cell cycle arrest and differentiation induced by TNF-a...

journal_title：Cancer letters

authors： Stika J,Vondrácek J,Hofmanová J,Simek V,Kozubík A

更新日期：2006-06-18 00:00:00

abstract：:Resistance to chemotherapy is a challenging problem for treatment of cancer patients and autophagy has been shown to mediate development of resistance. In this study we systematically screened a library of 306 known anti-cancer drugs for their ability to induce autophagy using a cell-based assay. 114 of the drugs were...

journal_title：Cancer letters

authors： Dyczynski M,Yu Y,Otrocka M,Parpal S,Braga T,Henley AB,Zazzi H,Lerner M,Wennerberg K,Viklund J,Martinsson J,Grandér D,De Milito A,Pokrovskaja Tamm K

更新日期：2018-10-28 00:00:00

abstract：:By comparing protein profiles of nasopharyngeal carcinoma HONE1 cells to transformed nasopharyngeal epithelial NP 69 cells, several clusters of differentially expressed proteins were identified. The increased expression of cytokeratin 8 (CK8) and pyruvate kinase M2 was a common feature in four NPC cell lines compared ...

journal_title：Cancer letters

authors： Wang Y,He QY,Tsao SW,Cheung YH,Wong A,Chiu JF

更新日期：2008-07-08 00:00:00