Abstract:
:A novel iron chelator, HDp44mT, has been reported to have potent anti-proliferative effects on cancer cells; however, the underlying mechanism of action is not well understood. In this study, we characterized the cytotoxic effect of HDp44mT in a chemo- and radio-resistant cell line (PC-3) of prostatic cancer origin. The activity of HDp44mT at nM concentrations was dependent on the intracellular GSH and atmospheric O(2) concentration, rather than iron deprivation. HDp44mT also radiosensitized PC-3 cells in a GSH-dependent manner. Interestingly, this radiosensitizing effect was observed under aerobic and, to a larger extent, hypoxic conditions, suggesting its potential utility as a radiosensitizer for some radioresistant tumors.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Tian J,Peehl DM,Zheng W,Knox SJdoi
10.1016/j.canlet.2010.07.010subject
Has Abstractpub_date
2010-12-08 00:00:00pages
231-7issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(10)00347-2journal_volume
298pub_type
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