Abstract:
:The tumorigenicity of 4-aminobiphenyl (4-ABP) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) were studied in combination with caloric restriction in the male neonatal CD1 mouse bioassay. 4-ABP and PhIP exhibited moderate and weak tumorigenicity, respectively, in ad libitum fed mice; however, none of the caloric restricted mice developed tumors. These results indicate that caloric restriction, even when begun 3 months after the conclusion of compound treatment, markedly inhibited 4-ABP- and PhIP-induced tumors in the CD1 mouse.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Von Tungeln LS,Bucci TJ,Hart RW,Kadlubar FF,Fu PPdoi
10.1016/0304-3835(96)04232-2subject
Has Abstractpub_date
1996-07-12 00:00:00pages
133-6issue
2eissn
0304-3835issn
1872-7980pii
0304383596042322journal_volume
104pub_type
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