Abstract:
:Epigenetic aberrations have been associated with cutaneous melanoma tumorigenesis and progression including dysregulated DNA gene promoter region methylation, histone modification, and microRNA. Several of these major epigenetic aberrations have been developed into biomarkers. Epigenetic biomarkers can be detected in tissue and in blood as circulating DNA in melanoma patients. There is strong evidence that biomarkers in cutaneous melanoma will have an important role as companions to therapeutics and overall patient management. Important progress has been made in epigenetic melanoma biomarker development and verification of clinical utility, and this review discusses some of the key current developments and existing challenges.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Greenberg ES,Chong KK,Huynh KT,Tanaka R,Hoon DSdoi
10.1016/j.canlet.2012.01.020subject
Has Abstractpub_date
2014-01-28 00:00:00pages
170-7issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(12)00053-5journal_volume
342pub_type
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