Abstract:
:This study investigated the role of miR-206 in estrogen receptor-α (ERα)-positive endometrial endometrioid adenocarcinoma (EEC). We profiled miR-206 expression in 30 EEC clinical samples using qRT-PCR, and explored its relationship with ERα and clinical parameters. A luciferase reporter assay assessed the ERα targeting potential of miR-206. Functional analyses of miR-206 were performed in EEC cell lines. MiRNA-206 expression decreased in ERα-positive EECs, and its expression was negatively correlated with ERα. MiRNA-206 overexpression inhibited ERα-dependent proliferation, impaired invasiveness and induced cell cycle arrest of ERα-positive EEC cell lines. Therefore, aberrantly expressed miRNA-206 may be associated with the development of ERα-positive EEC.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Chen X,Yan Q,Li S,Zhou L,Yang H,Yang Y,Liu X,Wan Xdoi
10.1016/j.canlet.2011.09.014subject
Has Abstractpub_date
2012-01-01 00:00:00pages
41-53issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(11)00557-Xjournal_volume
314pub_type
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