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Co-delivery of tumor-derived exosomes with alpha-galactosylceramide on dendritic cell-based immunotherapy for glioblastoma.

Abstract：

:Dendritic cell (DC) vaccine-based immunotherapy for glioblastoma multiforme (GBM) has shown apparent benefit in animal experiments and early-phase clinical trials, but the survival benefit is variable. In this work, we analyzed the mechanism of the potent antitumor immune response induced in vivo by tumor-associated antigen (TAA)-specific DCs with an invariant natural killer T (iNKT) cell adjuvant in orthotopic glioblastoma-bearing rats vaccinated with tumor-derived exosomes and α-galactosylceramide (α-GalCer) -pulsed DCs. Compared with traditional tumor lysate, exosomes were utilized as a more potent antigen to load DCs. iNKT cells, as an effective cellular adjuvant activated by α-GalCer, strengthened TAA presentation through their interaction with DCs. Co-delivery of tumor-derived exosomes with α-GalCer on a DC-based vaccine showed powerful effects in glioblastoma immunotherapy. This vaccine induced strong activation and proliferation of tumor-specific cytotoxic T lymphocytes, synergistically breaking the immune tolerance and improving the immunosuppressive environment.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Liu H,Chen L,Liu J,Meng H,Zhang R,Ma L,Wu L,Yu S,Shi F,Li Y,Zhang L,Wang L,Feng S,Zhang Q,Peng Y,Wu Q,Liu C,Chang X,Yang L,Uemura Y,Yu X,Liu T

doi

10.1016/j.canlet.2017.09.022

subject

Has Abstract

pub_date

2017-12-28 00:00:00

pages

182-190

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(17)30572-4

journal_volume

411

pub_type

杂志文章

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