Nemo-like kinase (NLK) primes colorectal cancer progression by releasing the E2F1 complex from HDAC1.

Abstract:

:Control of E2F1 activity is restricted via its interactions with RB1 and HDAC1. However, the detailed regulatory mechanisms underlying the E2F1/HDAC1 complex remain elusive. Here, we report that Nemo-like kinase (NLK) boosts cell cycle progression, which facilitates tumor development by releasing the E2F1 protein from HDAC1. Deletion of NLK largely blocks colorectal tumor proliferation and development. Moreover, RNA-seq shows that cell cycle is arrested at the G1/S phase in NLK-deficient cells and that the expression of E2F complex-targeted genes are affected, whereas overexpression of NLK but not an NLK mutant restores the wild-type phenotype. Mechanistically, we show that NLK interacts with the E2F1 complex, leading to disassembly of the E2F1/HDAC1 complex and thus diminishing the ability of E2F1 to bind to target gene promoters. Our results indicate that NLK boosts cell proliferation and E2F1 activity and controls the cell cycle switch by releasing HDAC1 from the E2F1 complex.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Li SZ,Zeng F,Li J,Shu QP,Zhang HH,Xu J,Ren JW,Zhang XD,Song XM,Du RL

doi

10.1016/j.canlet.2018.05.032

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

43-53

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(18)30365-3

journal_volume

431

pub_type

杂志文章
  • Peroxiredoxin I expression in human thyroid tumors.

    abstract::Peroxiredoxin I (Prx I) is newly discovered oxidative stress inducible protein, having a thioredoxin peroxidase activity. The Prx I expression level in 107 samples out of 60 thyroid lesions, including normal thyroid, tumors and thyroiditis including Graves' disease were examined using immunoblotting. Prx I expression ...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(99)00243-8

    authors: Yanagawa T,Ishikawa T,Ishii T,Tabuchi K,Iwasa S,Bannai S,Omura K,Suzuki H,Yoshida H

    更新日期:1999-10-18 00:00:00

  • Rap1GAP regulates renal cell carcinoma invasion.

    abstract::Although patients with localized and regional kidney tumors have a high survival rate, incidence of mortality significantly increases for patients with metastatic disease. It is imperative to decipher the molecular mechanisms of kidney tumor migration and invasion in order to develop effective therapies for patients w...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2012.01.022

    authors: Kim WJ,Gersey Z,Daaka Y

    更新日期:2012-07-01 00:00:00

  • Comprehensive genomics linking between neural development and cancer: neuroblastoma as a model.

    abstract::Cancer cells are derived from their precursor cells, which normally develop to the matured cells to form individual organs. Neuroblastoma, one of the most common pediatric solid tumors, originates from possible cancer stem cells derived from the neural crest. During the development, neural crest cells segregate into s...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审

    doi:10.1016/S0304-3835(03)00457-9

    authors: Nakagawara A,Ohira M

    更新日期:2004-02-20 00:00:00

  • Decreased expression of the seven ARP2/3 complex genes in human gastric cancers.

    abstract::The Arp2/3 complex and filamins play important roles in organization of actin cytoskeleton, and thus in cellular morphology and locomotion. We recently identified decreased expression of a gene for one of seven subunits of the Arp2/3 complex, the p41-Arc gene, and silencing of a filamin gene, the FLNc gene, in human g...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2004.03.020

    authors: Kaneda A,Kaminishi M,Sugimura T,Ushijima T

    更新日期:2004-08-30 00:00:00

  • Significant allelic loss of ANX7region (10q21) in hormone receptor negative breast carcinomas.

    abstract::Loss of heterozygosity (LOH) in the 10q21 region that harbors the tumor suppressor gene ANX7-GTPase gene have been found in 35% of prostate tumors. Therefore, the rationale for this study is that this gene could also be implicated in breast pathogenesis as well. We investigated allelic losses in microsatellites of the...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2004.01.018

    authors: Leighton X,Srikantan V,Pollard HB,Sukumar S,Srivastava M

    更新日期:2004-07-16 00:00:00

  • Effects of dietary retinyl palmitate and selenium on tumoricidal capacity of macrophages in mice undergoing tumor promotion.

    abstract::Dietary retinyl palmitate was administered for 22-30 weeks in CD-1 mice which had been initiated with 0.15 mumol of 7,12-dimethylbenz[a]anthracene (DMBA) and promoted with 8 nmol of 12-O-tetradecanoylphorbol-13-acetate (TPA) twice weekly thereafter. This treatment resulted in a dose response in both the tumoricidal ca...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(87)90089-9

    authors: Watson RR,Moriguchi S,Gensler HL

    更新日期:1987-08-01 00:00:00

  • Alterations at the Ink4a locus in transplacentally induced murine lung tumors.

    abstract::The malignant phenotype results from multiple genetic alterations, including the activation of oncogenes and inactivation of tumor suppressor genes. Activation of the Ki-ras oncogene has been implicated as an early event in the pathogenesis of lung adenocarcinomas in humans and experimental animal models. Previous stu...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(01)00647-4

    authors: Mizesko MC,Grewe C,Grabner A,Miller MS

    更新日期:2001-10-22 00:00:00

  • Cytotoxic effects of the components in heat-treated mistletoe (Viscum album).

    abstract::Major cytotoxic components were fractionated from Korean mistletoe and the changes of their cytotoxic effects caused by heat treatment were investigated. The high cytotoxicity of isolated lectin I completely disappeared by heating for 30 min. The fractions of viscotoxins and alkaloids maintained their activities even ...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(99)00043-9

    authors: Park JH,Hyun CK,Shin HK

    更新日期:1999-05-24 00:00:00

  • The role of the human ABCG2 multidrug transporter and its variants in cancer therapy and toxicology.

    abstract::The human multidrug resistance ABC transporters provide a protective function in our body against a large number of toxic compounds. These proteins, residing in the plasma membrane, perform an active, ATP-dependent extrusion of such xenobiotics. However, the same proteins are also used by the tumor cells to fight vari...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.canlet.2005.01.061

    authors: Cervenak J,Andrikovics H,Ozvegy-Laczka C,Tordai A,Német K,Váradi A,Sarkadi B

    更新日期:2006-03-08 00:00:00

  • Hypoxia and hypoxia inducible factors in tumor metabolism.

    abstract::Because of the abnormal vasculature, most growing solid tumors contain regions that experience either acute or chronic hypoxia. However, tumor cells can maintain a high glycolytic rate even when there is enough oxygen supply. Hypoxia-inducible factors (HIFs) play crucial role in the response of tumor cells to this dis...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.canlet.2014.01.032

    authors: Zeng W,Liu P,Pan W,Singh SR,Wei Y

    更新日期:2015-01-28 00:00:00

  • Effects of the pineal hormone melatonin on the anchorage-independent growth of human breast cancer cells (MCF-7) in a clonogenic culture system.

    abstract::Only physiological levels of melatonin exert an antiproliferative effect on MCF-7 breast cancer cells grown in an anchorage-dependent culture system. We investigated melatonin's effect on the anchorage-independent growth of MCF-7 cells as well as the dose-response characteristics of this indoleamine under clonogenic c...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(90)90240-x

    authors: Cos S,Blask DE

    更新日期:1990-04-20 00:00:00

  • Post-transplant lymphoproliferative disorders: from epidemiology to pathogenesis-driven treatment.

    abstract::Post-transplant lymphoproliferative disorders (PTLDs) represent the most severe complication of both solid organ and hematopoietic stem cell transplantation. The Epstein-Barr Virus (EBV) is the main driver of PTLD, particularly those occurring early after transplantation. EBV-driven malignancies are associated with se...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.canlet.2015.08.007

    authors: Petrara MR,Giunco S,Serraino D,Dolcetti R,De Rossi A

    更新日期:2015-12-01 00:00:00

  • Radiotherapy combined with immune checkpoint blockade immunotherapy: Achievements and challenges.

    abstract::To date, several kinds of immunomodulating monoclonal antibodies (mAbs) have been applied in clinical trials, such as anti-cytotoxic T-lymphocyte antigen-4 (anti-CTLA-4) mAb and anti-programmed death-1 (anti-PD-1) mAb. With the recent success of cancer immunotherapy, especially the checkpoint inhibitors, the renewed i...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.canlet.2015.05.012

    authors: Teng F,Kong L,Meng X,Yang J,Yu J

    更新日期:2015-08-28 00:00:00

  • Cytotoxic effect of RA233 on hypoxic B16 melanoma cells in vitro.

    abstract::The pyrimido-pyrimidine derivative RA233 was found to selectively kill cultured mouse B16 melanoma cells after prolonged hypoxia. At the optimum cytotoxic concentration (100 microM), RA233 reduced cell clonogenicity by about 80% when administered during long-term hypoxia of 4 days. Comparable cytotoxicity was also evi...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(88)90249-2

    authors: Stackpole CW,Omar RA,Fornabaio DM,Kim YS

    更新日期:1988-09-01 00:00:00

  • Evidence for various 20q status using allelotyping, CGH arrays, and quantitative PCR in distal CIN colon cancers.

    abstract::The genomic aberration profile of chromosome 20q in distal CIN colon carcinomas was analysed using allelotyping and CGH arrays. Allelotyping revealed carcinomas with allelic imbalance along the full long arm, and carcinomas with fully non-aberrant 20q. Oligonucleotide-based CGH showed that among the carcinomas without...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2009.03.012

    authors: Nicolet C,Guérin E,Neuville A,Kerckaert JP,Wicker N,Bergmann E,Brigand C,Kedinger M,Gaub MP,Guenot D

    更新日期:2009-09-18 00:00:00

  • SMYD2-dependent HSP90 methylation promotes cancer cell proliferation by regulating the chaperone complex formation.

    abstract::Heat shock protein 90 (HSP90) is a highly conserved molecular chaperone that facilitates the maturation of a wide range of proteins, and it has been recognized as a crucial facilitator of oncogene addiction and cancer cell survival. Although HSP90 function is regulated by a variety of post-translational modifications,...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2014.05.014

    authors: Hamamoto R,Toyokawa G,Nakakido M,Ueda K,Nakamura Y

    更新日期:2014-08-28 00:00:00

  • The timing of insulin/c-Ras signal is critical for its effect upon the differentiation of C3H10T1/2-derived preadipocytes.

    abstract::The effect of the peptide hormone insulin upon the differentiation of a 10T1/2-derived preadipocytic line was found to display a potent time-dependence. Insulin addition before cell confluence strongly enhanced differentiation, while addition after confluence had no effect. In keeping with the role of c-Ras as a downs...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(97)04724-1

    authors: Preston T,Brownell H,Raptis L

    更新日期:1997-05-19 00:00:00

  • Effect of bile acids on formation of azoxymethane-induced aberrant crypt foci in colostomized F344 rat colon.

    abstract::The effect of bile acids on the formation of azoxymethane induced aberrant crypt foci (ACF) was investigated using the fecal stream-excluded colons of colostomized F344 rats. The excluded colon was irrigated with saline or bile acids (1 mg/0.5 ml per day, 5 days/week) for 4 weeks. The mean numbers of ACF per colon in ...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(01)00525-0

    authors: Lin CX,Umemoto A,Seraj MJ,Mimura S,Monden Y

    更新日期:2001-08-28 00:00:00

  • Metabolic tumor burden: a new promising way to reach precise personalized therapy in PDAC.

    abstract::Pancreatic cancer is currently one of the deadliest solid malignancies and pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer. In the past decade, diagnostics and surgical techniques for PDAC have been evolving steadily; however, clinical outcomes of patients with PDAC have shown litt...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.canlet.2015.01.023

    authors: Xiang J,Liu L,Wang W,Xu H,Wu C,Xu J,Liu C,Long J,Ni Q,Yu X

    更新日期:2015-04-10 00:00:00

  • RNA-binding protein Lin28 in cancer and immunity.

    abstract::The highly conserved RNA-binding protein, Lin28, is involved in many biological processes, including development, reprogramming, pluripotency, and metabolism. Importantly, Lin28 functions as an oncogene, promoting tumor progression and metastasis in various human cancers. Lin28 can regulate gene expression either by d...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.canlet.2016.02.050

    authors: Jiang S,Baltimore D

    更新日期:2016-05-28 00:00:00

  • The dual role of mast cells in tumor fate.

    abstract::The exact role of mast cells in tumor growth is not clear and multifaceted. In some cases, mast cells stimulate while in others inhibit this process. This dual role may be explained to some extent by the huge number of bioactive molecules stored in mast cell granules, as well as differences between tumor microenvironm...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.canlet.2018.07.005

    authors: Ribatti D,Tamma R,Crivellato E

    更新日期:2018-10-01 00:00:00

  • HLA-A, B, C, DR and DQ expression and hepatocellular carcinoma: study of 205 Italian subjects.

    abstract::We have evaluated the frequency of HLA class I and II antigens in 205 Italian patients with hepatocellular carcinoma (HCC) and 749 blood donors (controls). Moreover, we have looked for correlations between HLA antigen frequencies and HBV and/or HCV infections in HCC patients. We found great differences in HLA antigen ...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:

    authors: Ricci G,Colombo C,Ghiazza B,Porta C,Moroni M,Illeni MT

    更新日期:1995-11-27 00:00:00

  • Further investigations into the effect of non-benzo ring bay-region methyl substituents on tumor-initiating activity of polycyclic hydrocarbons.

    abstract::The effect of a methyl substituent at the non-benzo ring bay-region position of benzo[e]pyrene (B[e]P), cholanthrene (CA) and dibenz[a,j]anthracene (DB[a,j]A) on skin tumor-initiating activity was examined. A methyl substituent at the 1-carbon of B[e]P enhanced tumor-initiating activity of the parent compound (0.18 vs...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(87)90025-5

    authors: Sawyer TW,Chang K,Harvey RG,DiGiovanni J

    更新日期:1987-09-01 00:00:00

  • Immunotherapy in liver tumors: II. Intratumoral injection with activated tumor-infiltrating lymphocytes, intrasplenic administration of recombinant interleukin-2 and interferon alpha causes tumor regression and lysis.

    abstract::This study tested the effect of intratumoral injection with activated tumor-infiltrating lymphocytes (TIL), and simultaneous administration of recombinant interleukin-2 (rIL-2) and interferon alpha (IFN-alpha) (LII protocol), on mouse liver tumor. Group I (n = 10) served as the controls. Group II (n = 17) received rIL...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(94)90236-4

    authors: Liu DL,Håkansson CH,Seifert J

    更新日期:1994-09-30 00:00:00

  • p53 accumulation in the organs of low-dose X-ray-irradiated mice.

    abstract::In order to search for the direct evidence of cellular response to low-dose radiation, we investigated wild-type p53 protein accumulation in several organs of mice after exposure to low doses of X-rays. Significant p53 accumulation within 24 h was observed in the mouse adrenal glands and pancreas after X-ray irradiati...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(96)04235-8

    authors: Wang X,Matsumoto H,Takahashi A,Nakano T,Okaichi K,Ihara M,Ohnishi T

    更新日期:1996-06-24 00:00:00

  • Inhibition of MDR1 gene expression by H-87, a selective inhibitor of cAMP-dependent protein kinase.

    abstract::N-[2-(p-bromocinnamylmethylamino) ethyl]-5-isoquinolinesulfonamide (H-87), a newly synthesized inhibitor of protein kinase A, significantly decreased the drug resistance of multidrug resistant human U937/M cells, mouse FM3A/M and P388/M cells. Northern blot analysis showed MDR1 gene expression was decreased in H-87-tr...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(93)90041-7

    authors: Kim SH,Park JI,Chung BS,Kang CD,Hidaka H

    更新日期:1993-10-15 00:00:00

  • Infrequent Ki-ras and an absence of p53 mutations in hepatocellular carcinomas induced by a choline deficient L-amino acid defined diet in rats.

    abstract::Mutations of Ki-ras and p53 genes in hepatocellular carcinomas (HCCs) induced by the choline deficient L-amino acid defined (CDAA) diet in rats were investigated by polymerase chain reaction (PCR), single strand conformation polymorphism (SSCP) analysis followed by direct sequencing. Male Fischer 344 rats, 6 weeks old...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(96)04405-9

    authors: Tsujiuchi T,Kido A,Nakae D,Takahama M,Majima T,Kobitsu K,Okajima E,Tsutsumi M,Denda A,Konishi Y

    更新日期:1996-11-12 00:00:00

  • Helicobacter pylori upregulates Nanog and Oct4 via Wnt/β-catenin signaling pathway to promote cancer stem cell-like properties in human gastric cancer.

    abstract::Helicobacter pylori (H. pylori) infection is considered a major risk factor for gastric cancer. CagA behaves as a major bacterial oncoprotein playing a key role in H. pylori-induced tumorigenesis. Cancer stem cells (CSCs) are believed to possess the ability to initiate tumorigenesis and promote progression. Although s...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2016.02.032

    authors: Yong X,Tang B,Xiao YF,Xie R,Qin Y,Luo G,Hu CJ,Dong H,Yang SM

    更新日期:2016-05-01 00:00:00

  • Application of CRISPR-mediated genome engineering in cancer research.

    abstract::Cancer is a multistep process that arises from a series of genetic and epigenetic events. With recent technological advances there has been a burst in genome sequencing and epigenetic studies revealing a plethora of alterations that may contribute to cancer. However, the great challenge for the cancer research communi...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.canlet.2016.03.029

    authors: Sayin VI,Papagiannakopoulos T

    更新日期:2017-02-28 00:00:00

  • Primary brain tumor incidence in mice exposed to split-dose ionizing radiation and circularly polarized 60 Hz magnetic fields.

    abstract::Three sections of brain tissue from 2,657 female C57BL/6 mice were stained with hematoxylin and eosin and evaluated microscopically for proliferative lesions. Mice had been treated with either split-dose ionizing radiation (0, 3.0, 4.0 and 5.1 Gy), chronic lifetime 60 Hz circularly polarized magnetic field exposure (a...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(99)00286-4

    authors: Kharazi AI,Babbitt JT,Hahn TJ

    更新日期:1999-12-01 00:00:00