Toxoplasma gondii infection in cancer patients: prevalence, risk factors, genotypes and association with clinical diagnosis.

abstract：:Since Shh pathway effector, Gli1, is overexpressed in gliomas, we investigated the effect of novel Shh inhibitor SANT-1 on glioma cell viability. Though SANT-1 failed to induce apoptosis, it reduced proliferation of glioma stem-like cells. Apart from canonical Shh cascade, Gli1 is also induced by non-canonical pathway...

journal_title：Cancer letters

authors： Dixit D,Ghildiyal R,Anto NP,Ghosh S,Sharma V,Sen E

更新日期：2013-08-19 00:00:00

abstract：:Interstitial fluid pressure was measured by the wick-in-needle technique in DMBA-induced rat mammary tumours during resting conditions and during noradrenaline infusion. The rate of infusion was chosen to increase the systemic blood pressure by 30-40 mmHg, known to result in a markedly increased vascular resistance of...

journal_title：Cancer letters

authors： Tveit E,Hultborn R,Weiss L

更新日期：1985-07-01 00:00:00

abstract：:Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer. Appropriate treatment of this aggressive and heterogeneous cancer requires accurate staging and prognostic stratification, as does patient selection for clinical trials. Over the past two decades, several staging systems and prognost...

journal_title：Cancer letters

authors： Cheng Z,Lei Z,Shen F

更新日期：2019-09-28 00:00:00

abstract：:The effects of carotenoids--alpha-carotene, beta-carotene, lycopene, beta-cryptoxanthin, zeaxanthin, lutein, canthaxanthin, astaxanthin--on the invasion of rat ascites hepatoma AH109A cells were investigated by co-culturing the hepatoma cells with rat mesentery-derived mesothelial cells (M-cells). All the carotenoids ...

journal_title：Cancer letters

authors： Kozuki Y,Miura Y,Yagasaki K

更新日期：2000-04-03 00:00:00

abstract：:6-(1-Hydroxyimino-4-methylpentyl)5,8-dimethyoxy 1,4-naphthoquinone S-52 (DMNQ S-52) was reported to have cytotoxic activity against L1210 leukemia cells. In the present study, we investigated the apoptotic mechanism of DMNQ S-52 in vitro and in vivo in murine solid cancer cells. DMNQ S-52 exerted cytotoxicity against ...

journal_title：Cancer letters

authors： Lee SJ,Sakurai H,Koizumi K,Song GY,Bae YS,Kim HM,Kang KS,Surh YJ,Saiki I,Kim SH

更新日期：2006-02-20 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is heterogeneous, rendering its current curative treatments ineffective. The emergence of single-cell genomics represents a powerful strategy in delineating the complex molecular landscapes of cancers. In this study, we demonstrated the feasibility and merit of using single-cell RNA sequ...

journal_title：Cancer letters

authors： Ho DW,Tsui YM,Sze KM,Chan LK,Cheung TT,Lee E,Sham PC,Tsui SK,Lee TK,Ng IO

更新日期：2019-09-10 00:00:00

abstract：:This aim of this study was to measure the typical free radical-induced products of DNA bases in cellular DNA of cervical cancer tissues directly irradiated by applying brachytherapy to the patients. Significant increases in the amounts of modified bases over the control level were observed in the samples isolated afte...

journal_title：Cancer letters

authors： Foksinski M,Jaruga P,Makarewicz R,Olinski R

更新日期：1998-10-23 00:00:00

abstract：:The present study evaluates the postnatal efficacy of Momordica charantia peel, pulp, seed and whole fruit extract via assessing the modulation in the biotransformation system enzymes of suckling neonates and lactating mice. The peel, seed or whole fruit extract of Momordica (100 microl/animal/day) independently induc...

journal_title：Cancer letters

authors： Singh A,Singh SP,Bamezai R

更新日期：1998-01-09 00:00:00

abstract：:Three sections of brain tissue from 2,657 female C57BL/6 mice were stained with hematoxylin and eosin and evaluated microscopically for proliferative lesions. Mice had been treated with either split-dose ionizing radiation (0, 3.0, 4.0 and 5.1 Gy), chronic lifetime 60 Hz circularly polarized magnetic field exposure (a...

journal_title：Cancer letters

authors： Kharazi AI,Babbitt JT,Hahn TJ

更新日期：1999-12-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest of all solid tumours and more effective therapy is urgently needed. The stroma is thought to play a critical role in tumour development and metastasis, and high stromal expression of the matricellular protein SPARC has been robustly associated with poor p...

journal_title：Cancer letters

authors： Munasinghe A,Malik K,Mohamedi F,Moaraf S,Kocher H,Jones L,Hill NJ

更新日期：2020-05-01 00:00:00

abstract：:Cell migration and invasion leading to metastasis is a major cause of death from endometrial cancer (EC). We have shown that the rate of EC cell migration is inversely related to the level of insulin-like growth factor protein-3 (IGFBP-3). Down-regulation of IGFBP-3 by siRNA in EC cells accelerated migration without a...

journal_title：Cancer letters

authors： Gribben L,Baxter RC,Marsh DJ

更新日期：2012-04-01 00:00:00

abstract：:Antibodies directed against the L1 cell adhesion protein inhibit growth of SKOV3ip human ovarian cancer cells in vitro and in vivo. Responses of SKOV3ip cells in vitro to anti-L1 mAb chCE7 and Genistein were investigated. Genistein potentiated the anti-proliferative and pro-apoptotic effects of chCE7 in SKOV3ip cells....

journal_title：Cancer letters

authors： Novak-Hofer I,Cohrs S,Grünberg J,Friedli A,Schlatter MC,Pfeifer M,Altevogt P,Schubiger PA

更新日期：2008-03-18 00:00:00

abstract：:To investigate mucin expression in breast cancer, immunohistochemical staining was performed on 30 mucinous carcinomas and 95 non-mucinous invasive carcinomas. MUC2 expression was detected in all mucinous carcinomas, but only in 11.1% of invasive ductal carcinomas, and in none of the invasive lobular carcinomas and me...

journal_title：Cancer letters

authors： Chu JS,Chang KJ

更新日期：1999-07-19 00:00:00

abstract：:Many studies have shown that the activation of beta-catenin signaling can promote oncogenesis, and it is therefore of interest to find agents that modulate this pathway. Recent work has shown using B lymphoma cells that infection by Epstein-Barr virus (EBV) and expression of its latent membrane protein (LMP)-1, cause ...

journal_title：Cancer letters

authors： Min HJ,Cho IR,Srisuttee R,Park EH,Cho DH,Ahn JH,Lee IS,Johnston RN,Oh S,Chung YH

更新日期：2009-04-18 00:00:00

abstract：:Parthanatos is a new form of programmed cell death that is regulated by hyper-activated PARP-1, and is emerging as a new strategy to kill cancer cells. Deoxypodophyllotoxin (DPT) is a natural chemical that is found to induce cancer cell death, in which the role of parthanatos is unknown. Thus, we investigated this iss...

journal_title：Cancer letters

authors： Ma D,Lu B,Feng C,Wang C,Wang Y,Luo T,Feng J,Jia H,Chi G,Luo Y,Ge P

更新日期：2016-02-28 00:00:00

abstract：:Cancer is a multistep process that arises from a series of genetic and epigenetic events. With recent technological advances there has been a burst in genome sequencing and epigenetic studies revealing a plethora of alterations that may contribute to cancer. However, the great challenge for the cancer research communi...

journal_title：Cancer letters

authors： Sayin VI,Papagiannakopoulos T

更新日期：2017-02-28 00:00:00

abstract：:Potassium bromate (KBrO(3)) is a rat renal carcinogen and a major drinking water disinfection by-product in water disinfected with ozone. Clear cell renal tumors, the most common form of human renal epithelial neoplasm, are rare in animals but are inducible by KBrO(3) in F344 rats. Detection of cytoplasmic periodic ac...

journal_title：Cancer letters

authors： Shiao YH,Kamata SI,Li LM,Hooth MJ,DeAngelo AB,Anderson LM,Wolf DC

更新日期：2002-12-10 00:00:00

abstract：:Ursodeoxycholic acid (UDCA) and its derivatives were examined for anti-angiogenic activities by using the chick embryo chorioallantoic membrane (CAM) assay. The presence of UDCA or its derivatives inhibited angiogenesis in a dose-dependent manner; the dose required for half-maximal inhibition (ID50) was 4 microg per C...

journal_title：Cancer letters

authors： Suh H,Jung EJ,Kim TH,Lee HY,Park YH,Kim KW

更新日期：1997-02-26 00:00:00

abstract：:Glioblastoma (GBM) is the most common and aggressive primary brain tumor with great invasiveness and resistance to chemotherapy, which presents a treatment challenge. In this study, we investigated the antitumor effect of Cedrol, a sesquiterpene alcohol isolated from Cedrus atlantica, against GBM cells in vitro and in...

journal_title：Cancer letters

authors： Chang KF,Huang XF,Chang JT,Huang YC,Weng JC,Tsai NM

更新日期：2020-12-28 00:00:00

abstract：:Neuroendocrine (carcinoid) tumours of the thymus are rare neoplasms characterized by a highly malignant clinical behavior. Some of these tumors are associated with MEN1. In this study we evaluated 10 cases of sporadic thymic neuroendocrine tumours using immunohistochemistry and comparative genomic hybridization (CGH)....

journal_title：Cancer letters

authors： Rieker RJ,Aulmann S,Penzel R,Schnabel PA,Blaeker H,Esposito I,Morresi-Hauf A,Otto HF,Hecker E,Dienemann H,Schirmacher P,Mechtersheimer G

更新日期：2005-06-01 00:00:00

abstract：:The presence and the involvement of cancer stem-like cells (CSCs) in tumor initiation and progression, and chemo-resistance are documented. Herein, we functionally analyzed melanoma stem-like cells (MSC)/CD133(+) cells on their resistance and response to taxol-induced apoptosis. Besides being taxol resistant, the CD13...

journal_title：Cancer letters

authors： El-Khattouti A,Selimovic D,Haïkel Y,Megahed M,Gomez CR,Hassan M

更新日期：2014-02-01 00:00:00

abstract：:The p53 signaling pathway plays critical roles in determining the radio-sensitivity of normal tissues but is frequently inactivated in cancer. In various cancer cells, p53 has different effects on radio-sensitivity through complex mechanisms. Acetylation of p53 is an important means of post-translational modifications...

journal_title：Cancer letters

authors： Zhang J,Shen L,Sun LQ

更新日期：2015-07-28 00:00:00

abstract：:Diet-induced changes in serum cholesterol levels and their relationship to mammary carcinogenesis initiated by 7,12-dimethylbenz[a]anthracene (DMBA) were studied in female Sprague-Dawley rats. DMBA was given to rats subjected to 3 dietary treatments: (1) a semipurified, cholesterol-free diet (SP); (2) the same diet wi...

journal_title：Cancer letters

authors： Klurfeld DM,Kritchevsky D

更新日期：1981-12-01 00:00:00

abstract：:As a third-generation platinum drug, oxaliplatin has been widely applied in colorectal cancer (CRC); however, acquired resistance to oxaliplatin has become a major obstacle. In the present study, we found that the nuclear transcription factor Y subunit beta (NFYB) and E2F transcription factor 1 (E2F1) expression level...

journal_title：Cancer letters

authors： Fang Z,Gong C,Yu S,Zhou W,Hassan W,Li H,Wang X,Hu Y,Gu K,Chen X,Hong B,Bao Y,Chen X,Zhang X,Liu H

更新日期：2018-02-28 00:00:00

abstract：:Overexpression of Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) is implicated in drug resistance and progression of multiple myeloma (MM). The basis for MARCKS induction and impact on MM are not known. Here we show that microRNA-34a (miR-34a), regulates MARCKS translation and is under-expressed in drug-resist...

journal_title：Cancer letters

authors： Zhang L,Rastgoo N,Wu J,Zhang M,Pourabdollah M,Zacksenhaus E,Chen Y,Chang H

更新日期：2020-06-28 00:00:00

abstract：:The influence of the carcinogen 2-acetylaminofluorene (2AAF) administration on splenic natural killer (NK) cell function in two strains of rats has been examined and compared with that of the non-carcinogenic analogue 4-acetylaminofluorene (4AAF). In both strains it was observed that daily exposure to 25 mg kg-1 2AAF ...

journal_title：Cancer letters

authors： Kimber I,Griffin AC,Jones K

更新日期：1986-01-01 00:00:00

abstract：:Formation of DNA-adducts by 3-BHA or its metabolites, i.e., tert-butyl-1,4-benzoquinone (TBQ) and 5-methoxy-3-tert-butyl-1,2-benzoquinone (3-TBOQ), as well as DNA-adduct formation by 4-nitroquinoline-N-oxide (4NQO), in rat forestomach were examined by an enzymatic 32P-postlabeling assay. Four DNA-adducts were clearly ...

journal_title：Cancer letters

authors： Saito K,Nakagawa S,Yoshitake A,Miyamoto J,Hirose M,Ito N

更新日期：1989-12-01 00:00:00

abstract：:Human epidermal growth factor receptor 2 (HER2), a member of the HER family of tyrosine kinases and a binding partner of Heat shock protein 90 (Hsp90), is found amplifies in approximately 25% breast cancers. Treatment of HER2+ breast cancers has been greatly improved in recent years, but the accompanying upregulation ...

journal_title：Cancer letters

authors： Huang W,Wu QD,Zhang M,Kong YL,Cao PR,Zheng W,Xu JH,Ye M

更新日期：2015-01-28 00:00:00

abstract：:Neuroblastoma (NB) is a common neuroectodermal tumor of childhood with low response to conventional therapy in patients with advanced stage disease. Among novel strategies, immumotherapy has attracted much interest. However, scanty information is available about the immunogenicity of human NB. Here, we review our data...

journal_title：Cancer letters

authors： Raffaghello L,Prigione I,Airoldi I,Camoriano M,Morandi F,Bocca P,Gambini C,Ferrone S,Pistoia V

更新日期：2005-10-18 00:00:00

abstract：:Tumor cells need to attain anoikis resistance to survive prior to metastasis making it a vital trait of malignancy. The molecular mechanism by which hepatocellular carcinoma (HCC) cells resist anoikis remains not fully understood. Here, we report that ZNF32 expression is markedly upregulated in HCC cells upon detachme...

journal_title：Cancer letters

authors： Li K,Zhao G,Ao J,Gong D,Zhang J,Chen Y,Li J,Huang L,Xiang R,Hu J,Lin P,Wei Y

更新日期：2019-02-01 00:00:00