Abstract:
:Neuroendocrine (carcinoid) tumours of the thymus are rare neoplasms characterized by a highly malignant clinical behavior. Some of these tumors are associated with MEN1. In this study we evaluated 10 cases of sporadic thymic neuroendocrine tumours using immunohistochemistry and comparative genomic hybridization (CGH). All tumours showed a diffuse expression of neuron specific enolase (NSE) and synaptophysin. Chromosomal imbalances were detected in 8/10 cases, the most frequent gains were seen on chromosome Xp (3/10 cases), 7p, 7q, 11q, 12q, and 20q (2/10 each), losses were most frequently detected at 6q (5/10 each), 6p (3/10 each), 4q (3/10 each), 3p, 10q, 11q and 13 q (2/10 each). These CGH data show a degree of overlap with chromosomal imbalances commonly observed in advanced thymomas.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Rieker RJ,Aulmann S,Penzel R,Schnabel PA,Blaeker H,Esposito I,Morresi-Hauf A,Otto HF,Hecker E,Dienemann H,Schirmacher P,Mechtersheimer Gdoi
10.1016/j.canlet.2004.10.027keywords:
subject
Has Abstractpub_date
2005-06-01 00:00:00pages
169-74issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(04)00810-9journal_volume
223pub_type
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