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The serine proteinase thrombin promotes migration of human renal carcinoma cells by a PKA-dependent mechanism.

Abstract：

:In this study, we demonstrated that thrombin activates protein kinase C (PKC), mitogen activated protein kinases (MAP kinases), transcription factor nuclear factor-kappa B (NF-kappa B), and cAMP-dependent protein kinase (PKA) in the human renal carcinoma cell line A-498. In addition, it enhanced the migratory capacity, but had no effect on the proliferation of A-498 cells. The effect of thrombin on migration could be blocked by the PKA inhibitor H-89 but was not influenced by inhibition of PKC, MAP kinases or NF-kappa B. We concluded, that thrombin acts as a regulator on human A-498 renal carcinoma cell migration including PKA.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Kaufmann R,Junker U,Junker K,Nuske K,Ranke C,Zieger M,Scheele J

doi

10.1016/s0304-3835(01)00870-9

keywords:

subject

Has Abstract

pub_date

2002-06-28 00:00:00

pages

183-90

issue

2

eissn

0304-3835

issn

1872-7980

pii

S0304383501008709

journal_volume

180

pub_type

杂志文章

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