Arsenic and chromium enhance transformation of bovine papillomavirus DNA-transfected C3H/10T1/2 cells.


:Tumor promoters such as phorbol esters, teleocidin and okadaic acid increase the numbers of multilayered, transformed foci produced by BPV DNA-transfected C3H/10T1/2 cells. We questioned whether arsenic and chromium, which are known human carcinogens also enhance transformation of BPV DNA-transfected C3H/10T1/2 cells. Cr(III) potassium sulfate at 100 microM enhanced transformation by 1.4-fold, but Cr(VI) as potassium chromate did not enhance transformation, although toxicity of potassium chromate may have prevented enhancement of transformation. Sodium arsenite (As(III) at 5 microM and sodium arsenate (As(V)) at 25 microM both enhanced neoplastic transformation by 6-fold. By comparison, in previous studies, sodium orthovanadate (V(IV)) or vanadyl sulfate (V(IV)) at 4 microM enhanced numbers of transformed foci by 25-50-fold. The comparatively strong enhancement of transformation by vanadium and phorbol esters suggests that neoplastic transformation may occur by mechanisms that are common to these compounds including alteration of tyrosine phosphorylation.


Cancer Lett


Cancer letters


Kowalski LA,Tsang SS,Davison AJ




Has Abstract


1996-05-15 00:00:00














  • Hematopoietic growth factors and tumor angiogenesis.

    abstract::Angiogenesis is regulated by numerous "classic" factors such as vascular endothelial growth factor (VEGF) and many other endogenous "non-classic"peptides, including erythropoietin (Epo), and granulocyte-/granulocyte macrophage colony stimulating factor (G-/GM-CSF). The latter play an important regulatory role in angio...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Ribatti D,Tamma R

    更新日期:2019-01-01 00:00:00

  • Ornithine decarboxylase induction in mouse kidney as indicator of renal damage. Differential nephrotoxic effect of anticancer antifolate drugs.

    abstract::High doses of folate and its quinazoline analogue with antitumour activity, N10-propargyl-5,8-dideazafolic acid (CB 3717), caused severe renal damage in mice, leading in the case of folate to death. The mouse kidneys increased in weight, which was accompanied by time- and dose-dependent induction of ornithine decarbox...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Manteuffel-Cymborowska M,Chmurzyńska W,Grzelakowska-Sztabert B

    更新日期:1991-09-01 00:00:00

  • Cancer-related transcriptional targets of the circadian gene NPAS2 identified by genome-wide ChIP-on-chip analysis.

    abstract::The transcription factor NPAS2 is one of nine human core circadian genes that influence a variety of biological processes by regulating the 24-h circadian rhythm. Recently, it has been shown that NPAS2 is a risk biomarker in human cancers and plays a role in tumorigenesis by affecting cancer-related gene expression, a...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Yi CH,Zheng T,Leaderer D,Hoffman A,Zhu Y

    更新日期:2009-11-01 00:00:00

  • Possible mechanism for differences in sensitivity to cis-platinum in human prostate tumor cell lines.

    abstract::Two human prostate tumor cell lines which exhibit a 2.4-fold difference in sensitivity to cis-platinum (cis-Pt) were found to possess slightly different sulphydryl contents, and the presence of a metallothionein-like zinc-binding protein was demonstrated in the line exhibiting relative resistance to cis-Pt. Although t...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Metcalfe SA,Cain K,Hill BT

    更新日期:1986-05-01 00:00:00

  • Oleanolic acid and its synthetic derivatives for the prevention and therapy of cancer: preclinical and clinical evidence.

    abstract::Oleanolic acid (OA, 3β-hydroxyolean-12-en-28-oic acid) is a ubiquitous pentacyclic multifunctional triterpenoid, widely found in several dietary and medicinal plants. Natural and synthetic OA derivatives can modulate multiple signaling pathways including nuclear factor-κB, AKT, signal transducer and activator of trans...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Shanmugam MK,Dai X,Kumar AP,Tan BK,Sethi G,Bishayee A

    更新日期:2014-05-01 00:00:00

  • Excision of DNA damage arising from chemicals of different carcinogenic potencies.

    abstract::Primary cultures of mouse embryo cells are more efficient in excising DNA-carcinogen adducts resulting from exposure to either 7-bromomethylbenz-[alpha]anthracene or the more carcinogen 7-bromomethyl-12-methylbenz[alpha]anthracene than are mouse L 929 cell suspension cultures. However, within each of these systems, th...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Dipple A,Schultz E

    更新日期:1979-07-01 00:00:00

  • N-α-acetyltransferase 10 protein promotes metastasis by stabilizing matrix metalloproteinase-2 protein in human osteosarcomas.

    abstract::N-α-Acetyltransferase 10 protein (Naa10p) mediates N-terminal acetylation of nascent proteins. Oncogenic or tumor suppressive roles of Naa10p were reported in cancers. Here, we report an oncogenic role of Naa10p in promoting metastasis of osteosarcomas. Higher NAA10 transcripts were observed in metastatic osteosarcoma...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Chien MH,Lee WJ,Yang YC,Tan P,Pan KF,Liu YC,Tsai HC,Hsu CH,Wen YC,Hsiao M,Hua KT

    更新日期:2018-10-01 00:00:00

  • Maternal or paternal exposure to radiation increases susceptibility to the induction of glutathione S-transferase-positive hepatic foci in offspring rats.

    abstract::Experiments were conducted to determine whether gamma-ray-induced genetic damage in parental rats can lead to the development of cancer in their offspring rats using glutathione S-transferase-positive (GST-P+) hepatic foci with or without the addition of diethylnitrosamine (DEN), a carcinogen. A single 1 Gy whole-body...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Lee YS,Lee MJ,Lee MS,Lee JH,Kim TH,Jang JJ

    更新日期:1998-10-23 00:00:00

  • Effect of bile acids on formation of azoxymethane-induced aberrant crypt foci in colostomized F344 rat colon.

    abstract::The effect of bile acids on the formation of azoxymethane induced aberrant crypt foci (ACF) was investigated using the fecal stream-excluded colons of colostomized F344 rats. The excluded colon was irrigated with saline or bile acids (1 mg/0.5 ml per day, 5 days/week) for 4 weeks. The mean numbers of ACF per colon in ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Lin CX,Umemoto A,Seraj MJ,Mimura S,Monden Y

    更新日期:2001-08-28 00:00:00

  • Novel anti-CD20 antibody TGLA with enhanced antibody-dependent cell-mediated cytotoxicity mediates potent anti-lymphoma activity.

    abstract::Rituximab is the first anti-cancer antibody approved by the FDA for the treatment of B-cell lymphoma. However, its efficacy remains variable and often modest. Some patients are initially unresponsive to rituximab or later develop resistance to it, and require alternative therapies. Rituximab activity has been thought ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Lv M,Lin Z,Qiao C,Gen S,Lang X,Li Y,Feng J,Shen B

    更新日期:2010-08-01 00:00:00

  • Adipose tissue-derived mesenchymal stem cells cultured at high density express IFN-β and TRAIL and suppress the growth of H460 human lung cancer cells.

    abstract::Although mesenchymal stem cells (MSCs) have been reported to inhibit tumor growth, the mechanism controlling this tumor suppression function is unclear. Here, we report that high-density (40,000 cells/cm2) cultured adipose tissue-derived MSCs (40K-ASCs) expressed interferon (IFN)-β and tumor necrosis factor-related ap...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Jung PY,Ryu H,Rhee KJ,Hwang S,Lee CG,Gwon SY,Kim J,Kim J,Yoo BS,Baik SK,Bae KS,Eom YW

    更新日期:2019-01-01 00:00:00

  • Studies on the cytostatic and cytotoxic effects and mode of action of 8-nitro-7-hydroxycoumarin.

    abstract::A derivative of coumarin, 8-nitro-7-hydroxycoumarin (8-NO2-7-OHC), was synthesised, purified and characterised. The cytostatic and cytotoxic nature of this compound was determined using both human and animal cell lines grown in vitro for 96 h in the presence of drug (0-500 microM, equivalent to 0-104 microg/ml). 8-NO2...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Egan D,James P,Cooke D,O'Kennedy R

    更新日期:1997-10-14 00:00:00

  • Effects of bombesin on the development of N-nitrosobis(2-oxopropyl)amine-induced pancreatic lesions in hamsters.

    abstract::Bombesin (BBS) has been shown to promote pancreatic growth as well as the development of pancreatic (pre)neoplasia in rats. The present study was carried out to determine the effects of bombesin on pancreatic growth and on the development of pancreatic (pre)neoplastic lesions in hamsters treated with N-nitrosobis(2-ox...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Meijers M,van Garderen-Hoetmer A,Lamers CB,Rovati LC,Jansen JB,Woutersen RA

    更新日期:1991-07-26 00:00:00

  • Mitosis and histopathology in rat liver during methylclofenapate-induced hyperplasia.

    abstract::Liver hyperplasia was induced in rats by daily administration of methylclofenapate (25 mg/kg by gavage). An increase in the incidence of colchicine-arrested metaphases was observed with peaks occurring at 40 h (1.3%), 64 h (6.4%) and 84 h (6.8%) after the start of treatment. This response contrasted with the much larg...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Bybee A,Styles JA,Beck SL,Blackburn D

    更新日期:1990-07-16 00:00:00

  • Serum evaluation of basic fibroblast growth factor in cervical cancer patients.

    abstract::We present the data of 105 serum samples from 20 patients suffering from cervical cancer. Mean serum levels of basic fibroblast growth factor (bFGF) in patients with or without tumor present were 31.3 +/- 32.1 (minimum 0, maximum 156.7) pg/ml and 4.8 +/- 6.8 (minimum 0, maximum 29.6) pg/ml, respectively (P = 0.0001). ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Sliutz G,Tempfer C,Obermair A,Reinthaller A,Gitsch G,Kainz C

    更新日期:1995-08-01 00:00:00

  • gamma-Glutamyltranspeptidase activity in a human pancreatic cancer cell line (HPC-Y1) in serum-free chemically defined medium.

    abstract::gamma-Glutamyltranspeptidase (gamma-GTP) activity was found in a human pancreatic cancer cell line, HPC-Y1, cultivated in a serum-free chemically defined medium. The gamma-GTP stained in the cytoplasms as fine granules and was produced constantly in a protein-free chemically defined medium. The detergent- or protease-...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Yamaguchi N,Sugimoto M,Kawai K

    更新日期:1984-12-01 00:00:00

  • Induction of murine fibrosarcomas by low dose treatment with 3-methylcholanthrene followed by promotion with 12-O-tetradecanoyl-phorbol-13-acetate.

    abstract::Repeated application of the tumor promoter 12-O-tetradecanoyl phorbol-13-acetate (TPA) to the skin of mice previously treated with an initiating dose of the carcinogen 7,12-dimethylbenz[a] anthracene has been shown to lead to an increased incidence of papilloma. The studies presented here describe a modified murine tw...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Devens BH,Lundak RL,Byus CV

    更新日期:1984-01-01 00:00:00

  • Metabolic alterations and drug sensitivity of tyrosine kinase inhibitor resistant leukemia cells with a FLT3/ITD mutation.

    abstract::Internal tandem duplication (ITD) of the juxtamembrane region of FMS-like tyrosine kinase-3 (FLT3) receptor is a common type of mutation in adult acute myeloid leukemia (AML), and patient response to FLT3 inhibitors appears to be transient due to the emergence of drug resistance. We established two sorafenib-resistant...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Huang A,Ju HQ,Liu K,Zhan G,Liu D,Wen S,Garcia-Manero G,Huang P,Hu Y

    更新日期:2016-07-28 00:00:00

  • Suppression of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced DNA damage in rat colon after grapefruit juice intake.

    abstract::The influence of grapefruit juice intake on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced colon DNA damage was examined using comet assay in F344 rats given 60 mg/kg of PhIP by gavage. F344 rats allowed free access to grapefruit juice for 5 days experienced clearly reduced DNA damage in the colon to a...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Miyata M,Takano H,Takahashi K,Sasaki YF,Yamazoe Y

    更新日期:2002-09-08 00:00:00

  • Inhibition of vascular endothelial growth factor induced mitogenesis of human endothelial cells by a chimeric anti-kinase insert domain-containing receptor antibody.

    abstract::The kinase insert domain-containing receptor (KDR) is the human vascular endothelial growth factor (VEGF) receptor responsible for the mitogenic and angiogenic effects of VEGF. There is much experimental evidence to suggest that the VEGF/KDR pathway plays an important role in tumor angiogenesis, a process essential fo...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Zhu Z,Lu D,Kotanides H,Santiago A,Jimenez X,Simcox T,Hicklin DJ,Bohlen P,Witte L

    更新日期:1999-03-01 00:00:00

  • Frequent ras gene mutations in squamous cell cervical cancer.

    abstract::Eighty samples of cervical invasive squamous cell carcinoma were examined for ras gene mutations using polymerase chain reaction (PCR) followed by restriction enzyme digestion. We found 28 (35%) cervical cancers contained ras mutations at H-ras codon 12, 49 (61%) at K-ras codon 12, and 5 (6%) at K-ras codon 13. There ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Wong YF,Chung TK,Cheung TH,Lam SK,Xu YG,Chang AM

    更新日期:1995-08-16 00:00:00

  • Diurnal variation in the response of gamma-ray-induced apoptosis in the mouse intestinal epithelium.

    abstract::The appearance of apoptosis has been used as an index of carcinogen-induced damage incurred by the intestinal epithelium. Here we report that the cytotoxic response elicited by gamma radiation in the duodenal and colonic epithelium of the mouse is markedly affected by the time of day at which the animals are irradiate...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Duncan AM,Ronen A,Blakey DH

    更新日期:1983-12-01 00:00:00

  • Inhibition of azoxymethane-induced intestinal cancer by disulfiram.

    abstract::Sprague--Dawley rats, both intact and colostomized animals, were given 24 weekly injections of azoxymethane. Rats were fed either Rat Purina Chow or the same diet plus 0.25% disulfiram. In the intact animals, disulfiram reduced tumors from an average of 6.3 to 0.95. The number of rats developing tumors was reduced fro...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Nigro ND,Campbell RL

    更新日期:1978-08-01 00:00:00

  • Identification of differentially expressed genes after PPM1D silencing in breast cancer.

    abstract::Amplification and overexpression of PPM1D (protein phosphatase magnesium-dependent 1 delta) has been observed in various cancer cell lines and primary tumors and has also been associated with cancers of poor prognosis. In addition to the negative feedback regulation of p38-p53 signaling, PPM1D inhibits other tumor sup...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Pärssinen J,Alarmo EL,Khan S,Karhu R,Vihinen M,Kallioniemi A

    更新日期:2008-01-18 00:00:00

  • Failure of phenethyl isothiocyanate to inhibit hamster tumorigenesis induced by N-nitrosobis(2-oxopropyl)amine when given during the post-initiation phase.

    abstract::The chemopreventive influence of phenethyl isothiocyanate (PEITC) during the post-initiation stage was investigated in the N-nitrosobis(2-oxopropyl)amine (BOP)-initiated hamster tumorigenesis model. A total of 120 female 5-week-old hamsters were divided into six groups. Animals in groups 1-3, each consisting of 30 ham...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Nishikawa A,Furukawa F,Kasahara K,Tanakamaru Z,Miyauchi M,Nakamura H,Ikeda T,Imazawa T,Hirose M

    更新日期:1999-07-01 00:00:00

  • Effect of alpha tocopheryl succinate on cyclic AMP-dependent protein kinase activity in murine B-16 melanoma cells in culture.

    abstract::d-Alpha tocopheryl succinate (vitamin E succinate), which inhibited growth and survival, and induced differentiation in murine B-16 melanoma cells in culture, increased adenosine 3',5'cyclic monophosphate-(cAMP)-dependent protein kinase (PK) activity without increasing the cellular cAMP level. Prostaglandin (PG)A2, wh...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Torelli S,Masoudi F,Prasad KN

    更新日期:1988-03-01 00:00:00

  • Adipocytokines visfatin and resistin in breast cancer: Clinical relevance, biological mechanisms, and therapeutic potential.

    abstract::Obesity is one of the major modifiable risk factors in breast cancer, with obese adipose tissue showing a pathological role in breast cancer development and malignancy via the release of secretory factors, such as proinflammatory cytokines and adipocytokines. The current article focuses on visfatin and resistin, two s...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Wang YY,Hung AC,Lo S,Yuan SF

    更新日期:2021-02-01 00:00:00

  • The biology, function and clinical implications of exosomes in lung cancer.

    abstract::Exosomes are 30-100 nm small membrane vesicles of endocytic origin that are secreted by all types of cells, and can also be found in various body fluids. Increasing evidence implicates that exosomes confer stability and can deliver their cargos such as proteins and nucleic acids to specific cell types, which subsequen...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Zhou L,Lv T,Zhang Q,Zhu Q,Zhan P,Zhu S,Zhang J,Song Y

    更新日期:2017-10-28 00:00:00

  • CXCR4 mediates the proliferation of glioblastoma progenitor cells.

    abstract::Increasing evidence points to a fundamental role for cancer stem cells (CSC) in the initiation and propagation of many tumors. As such, in the context of glioblastoma multiforme (GBM), the development of treatment strategies specifically targeted towards CSC-like populations may hold significant therapeutic promise. T...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Ehtesham M,Mapara KY,Stevenson CB,Thompson RC

    更新日期:2009-02-18 00:00:00

  • Influence of lithium on mammary tumor growth in vivo.

    abstract::The possibility that lithium ions stimulate growth of mammary tumors in vivo has been suggested by their mitogenic action in vitro on normal and neoplastic mammary epithelium [8] and their clinical use as stimulators of neutrophil production in tumor-bearing patients treated with cytotoxic drugs [14,15]. Three experim...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Ziche M,Maiorana A,Oka T,Gullino PM

    更新日期:1980-05-01 00:00:00