Abstract:
:Because lipoperoxides seem able to modulate tumor growth, we have examined the concomitant effects of dietary antioxidant (vitamin E) and of a high amount of polyunsaturated fatty acids (PUFA) in a model of chemically-induced mammary carcinogenesis. Two groups of rats received a high fat diet with or without added vitamin E and mammary tumors were initiated in both groups by an injection of carcinogen. Tumor growth was followed in both groups. We found that tumor incidence and growth were decreased in rats with no added vitamin E in diet, suggesting a protective role of oxidized PUFA at later stages of carcinogenesis.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Lhuillery C,Cognault S,Germain E,Jourdan ML,Bougnoux Pdoi
10.1016/s0304-3835(97)04671-5subject
Has Abstractpub_date
1997-03-19 00:00:00pages
233-4issue
1-2eissn
0304-3835issn
1872-7980pii
S0304-3835(97)04671-5journal_volume
114pub_type
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