Abstract：
:Multiple cancers contain subpopulations that exhibit characteristics of cancer stem cells (CSCs), the ability to self-renew and seed heterogeneous tumors. Recent evidence suggests two potentially overlapping models for these phenotypes: one where stem cells arise from multipotent progenitor cells, and another where they are created via an epithelial to mesenchymal transition. Unraveling this issue is critical, as it underlies phenomena such as metastasis and therapeutic resistance. Therefore, there is intense interest in understanding these two types of CSSs, how they differ from differentiated cancer cells, the mechanisms that drive their phenotypes, and how that knowledge can be incorporated into therapeutics.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Chang JT,Mani SAdoi
10.1016/j.canlet.2013.03.004subject
Has Abstractpub_date
2013-11-28 00:00:00pages
16-23issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(13)00227-9journal_volume
341pub_type
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