Abstract：
:The carcinogenic effects of the fungicide manganese ethylenebisdithiocarbamate (maneb) have been investigated in 2 populations of adult crested newt, which have different prevalences of spontaneous melanoma. Animals were exposed percutaneously to a 5 ppm solution of maneb 4 days a week for 37 weeks. No differences in tumor incidence were found between control and maneb-treated animals of either population. Most of the control and treated animals from Settala (Milan) died within 7 months because of the development of widely disseminated melanomas. Tumor incidence was 94% in controls and 98% in maneb-treated newts. In the population from Bagnaia (Perugia) the incidences of melanoma were 7% and 2%, respectively.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Zavanella T,Zaffaroni NP,Arias Edoi
10.1016/0304-3835(80)90033-6subject
Has Abstractpub_date
1980-08-01 00:00:00pages
109-16issue
2eissn
0304-3835issn
1872-7980pii
0304-3835(80)90033-6journal_volume
10pub_type
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