Abstract：
:Although it is well known that ovarian endometriosis occasionally gives rise to ovarian cancers with specific histology such as endometrioid and clear cell carcinomas, its etiology is not fully understood. We have shown that a stressful microenvironment within the endometriotic cyst may lead to cancer development by inducing unique gene expressions, which potentially serves as a molecular marker for treatment modality. In this review, by referring to other articles in this field, we explore how the carcinogenic microenvironment affects the phenotype and gene expression of a cancer, and how we can develop new treatment based on this concept.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Mandai M,Matsumura N,Baba T,Yamaguchi K,Hamanishi J,Konishi Idoi
10.1016/j.canlet.2011.06.039subject
Has Abstractpub_date
2011-11-28 00:00:00pages
129-33issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(11)00396-Xjournal_volume
310pub_type
杂志文章,评审相关文献
CANCER LETTERS文献大全abstract：:The acute intraperitoneal toxicities of chlorambucil and chlorambucil-spermidine conjugate have been compared, in mice. Both compounds were neurotoxic and also caused a prolonged fall in bodyweight and a depletion of lymphocyte numbers associated with a fall in the total leukocyte count and loss of spleen and thymus w...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(94)90278-x
更新日期：1994-10-14 00:00:00
abstract：:CD95, TNFR1, TRAILR1 and TRAILR2 belong to a subgroup of TNF receptors which is characterized by a conserved cell death-inducing protein domain that connects these receptors to the apoptotic machinery of the cell. Activation of death receptors in malignant cells attracts increasing attention as a principle to fight ca...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2010.12.019
更新日期：2013-05-28 00:00:00
abstract：:The intracellular concentrations of adenosine 3',5'-cyclic monophosphate (cAMP) in colonic tumors induced in adult male Holtzman rats by 1,2-dimethylhydrazine (DMH) were found to be 1/2 the concentration found in normal large bowel tissue. Intracellular concentrations of guanosine 3'-5'-cyclic monophosphate (cGMP) in ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(78)93192-0
更新日期：1978-01-01 00:00:00
abstract：:The polymorphism in the ALDH2 gene plays a central role in Asian alcohol hypersensitivity and has been associated with the risk for esophageal cancer. In the present study, we attempted to examine associations between the ADH2 and ALDH2 polymorphisms, alcohol drinking and hepatocellular carcinoma (HCC) development in ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(99)00343-2
更新日期：2000-02-28 00:00:00
abstract：:Exosomes are 30-100 nm small membrane vesicles of endocytic origin that are secreted by all types of cells, and can also be found in various body fluids. Increasing evidence implicates that exosomes confer stability and can deliver their cargos such as proteins and nucleic acids to specific cell types, which subsequen...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2017.08.003
更新日期：2017-10-28 00:00:00
abstract：:The primary aim of this study was to find novel chemopreventive agents effective against breast cancer. Endoplasmic reticulum (ER) stress can induce apoptosis through the unfolded protein response (UPR). 2'-Hydroxy-2,3,5'-trimethoxychalcone (DK143) is a synthetic flavonoid derivative. The present study provides eviden...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2015.12.017
更新日期：2016-03-01 00:00:00
abstract：:In this study, we investigated the anticancer efficacy of pegylated liposomes containing 6BrCaQ, an hsp90 inhibitor derived from novobiocin. 6BrCaQ has been previously identified as the most potent compound in a series of quinoleic novobiocin analogs but is poorly water-soluble. We investigated, for the first time, th...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2018.06.001
更新日期：2018-09-28 00:00:00
abstract：:The growth of a transplantable myeloid leukaemia into its syngeneic host is accompanied by a progressive increase in the number of blood monocytes. These were shown to be of host origin and were not derived from the inoculated leukaemia cells. The host response which is responsible for the monocytosis differs from tha...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(75)94893-4
更新日期：1975-09-01 00:00:00
abstract：:RNA interference (RNAi) is an evolutionary conserved mechanism for specific gene silencing. There are currently numerous cancer therapy clinical trials based on RNAi technology. Using an adenoviral system as a delivery mediator of RNAi, we investigated the therapeutic effects of targeting three genes simultaneously in...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2011.05.028
更新日期：2011-10-28 00:00:00
abstract：:Thyroid hormone receptor interactor 4 (TRIP4), a subunit of the tetrameric nuclear activating signal co-integrator 1 (ASC-1) complex, exerts pro-tumorigenic effects. The role for TRIP4 in the regulation of cervical cancer growth and radiation resistance is presently unknown. In this study, TRIP4 was found to be highly...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2019.03.017
更新日期：2019-06-28 00:00:00
abstract：:We induced tolerance to hexadecylphosphocholine (HePC) in the human epidermoid tumor cell line, KB. After 70 weeks of adaptation, the IC50 of HePC in the resistant cells KBr was 32-fold higher than in parental KB cells, and they were 30-fold more resistant to another ether lipid analogue, ET-18-OCH3. The KBr cells als...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(99)00146-9
更新日期：1999-08-03 00:00:00
abstract：:We have studied whether the cell proliferation rate modifies the inhibitory actions of melatonin on MCF-7 cell growth. The proliferative rate of cells was altered by plating them at different densities (5 x 10(4) to 100 x 10(4) cells/dish) in media with low charcoal-stripped serum concentrations. In this way, populati...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(95)03811-a
更新日期：1995-07-13 00:00:00
abstract：:Human hepatoma Hep 3B cells underwent apoptosis in response to 100 microM all-trans retinoic acid (RA) in full serum (10% fetal calf serum) condition in vitro. Cell death began approximately 24 h following treatment, with more than 80% of the cells dead after 60 h. The dead cells, mainly detached cells, exhibited cond...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(96)04407-2
更新日期：1996-10-01 00:00:00
abstract：:Thrombospondin-1 is one of most important natural angiogenic inhibitors. The three thrombospondin-1 type 1 repeats (3TSR), an anti-angiogenic domain of thrombospondin-1, is a promising novel agent for anti-angiogenic treatment. In the present study, we showed 3TSR was biologically stable at least for 7 days in mini-os...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2006.04.003
更新日期：2007-03-08 00:00:00
abstract：:A novel second generation retroviral producer cell strategy (an adenoviral/retroviral combined delivery system) has been developed by this laboratory. In the present studies, this delivery system was used to examine its delivery efficiency in vitro and in vivo by using a marker gene, LacZ, and a therapeutic gene, herp...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(02)00241-0
更新日期：2002-10-28 00:00:00
abstract：:Potassium bromate (KBrO(3)) is a rat renal carcinogen and a major drinking water disinfection by-product in water disinfected with ozone. Clear cell renal tumors, the most common form of human renal epithelial neoplasm, are rare in animals but are inducible by KBrO(3) in F344 rats. Detection of cytoplasmic periodic ac...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(02)00407-x
更新日期：2002-12-10 00:00:00
abstract：:We have successfully generated cytotoxic monoclonal antibodies against a rat histiocytoma, AK-5. Monoclonal antibodies obtained after fusing immunized rat splenocytes with SP2/0 myeloma, were cytotoxic to AK-5 cells in the presence of complement. These monoclonals were highly specific and did not show any cross reacti...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(92)90077-9
更新日期：1992-06-15 00:00:00
abstract：:Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer. Appropriate treatment of this aggressive and heterogeneous cancer requires accurate staging and prognostic stratification, as does patient selection for clinical trials. Over the past two decades, several staging systems and prognost...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2019.114426
更新日期：2019-09-28 00:00:00
abstract：:Colorectal cancer (CRC) is one of the most common neoplasms and a leading cause of death related to cancer worldwide. Hereditary nonpolyposis colorectal cancer (HNPCC) is the most frequent autosomal dominant predisposition to the development of CRC, accounting for approximately 2.5% of the total CRC burden in Spain. G...
journal_title：Cancer letters
pub_type： 杂志文章,多中心研究
doi：10.1016/j.canlet.2005.01.036
更新日期：2005-07-08 00:00:00
abstract：:Apoptosis is a gene-directed program that is engaged to efficiently eliminate dysfunctional cells. Evasion of apoptosis may be an important gate to tumor initiation and therapy resistance. Like any other developmental program, apoptosis can be disrupted by several genetic aberrations driving malignant cells into an un...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2016.05.012
更新日期：2016-08-10 00:00:00
abstract：:Neoxanthin and fucoxanthin, which have the characteristic structure of 5,6-monoepoxide and an allenic bond, were previously found to reduce the viability of human prostate cancer cells most intensively among 15 dietary carotenoids tested. In the present study, the induction of apoptosis in PC-3 cells by these two caro...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2004.07.048
更新日期：2005-03-18 00:00:00
abstract：:This study was carried out to evaluate the diagnostic utility of autofluorescence photography for oral mucosal lesions. The materials consisted of 15 chemically-induced lesions containing carcinomas in 15 hamsters, and 32 oral lesions in 30 patients. In the animal models, orange fluorescence was detected in all squamo...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(96)04388-1
更新日期：1996-11-12 00:00:00
abstract：:Epithelial-to-mesenchymal transition (EMT) is the fundamental process by which an epithelial cell loses its epithelial characteristics including cell polarity and acquires mesenchymal and stemness-related features. Therefore, we investigated whether malignant pleural mesothelioma (MPMs) histologies were associated wit...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2011.01.009
更新日期：2011-03-28 00:00:00
abstract：:We investigated the relationship between ErbB-2 and HLA in order to clarify the clinical and genetic factors related to Japanese patients with lung cancer. Thirty-nine of the 73 lung cancer patients (53.4%) had elevated levels of ErbB-2. Only seven of 23 (30. 4%) patients with small cell carcinoma had elevated ErbB-2 ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(99)00437-1
更新日期：2000-04-28 00:00:00
abstract：:Bone metastasis is an important cause of morbidity in advanced prostate cancer. Bisphosphonates are widely used for the treatment and prevention of osteoporosis, but recently have been observed to be effective in controlling prostate cancer metastasis. Since aminopeptidase N (AP-N) is known to be involved in the metas...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2005.06.006
更新日期：2006-06-18 00:00:00
abstract：:Rats bearing the Yoshida AH-130 ascites hepatoma, a cachectic rat tumour, showed signs of important muscle wasting with reduced muscle weights. This phenomenon was associated with a decreased rate of in vivo alanine oxidation as measured by the production of 14CO2 from [U-14C]alanine intragastrically administered. It ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(94)90212-7
更新日期：1994-12-09 00:00:00
abstract：:Helicobacter pylori infection is the most important risk factor in the development of non-cardia gastric adenocarcinoma; host genetic variability and dietary co-factors also modulate risk. Because most H. pylori infections do not cause cancer, H. pylori heterogeneity has been investigated to identify possible virulenc...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2008.11.016
更新日期：2009-09-08 00:00:00
abstract：:The three most common genetic abnormalities occurring in malignant lymphomas involve alterations resulting in the deregulated expression of the c-myc and bcl-2 oncogenes and the inactivation of the p53 tumor suppressor gene. Relevant strains of genetically engineered mice, including bcl-2-Ig and E mu-myc transgenic mi...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(95)03836-l
更新日期：1995-07-20 00:00:00
abstract：:Pancreatic ductal adenocarcinoma (PDAC) is highly aggressive disease and current treatment regimens fail to effectively cure PDAC. Development of resistance to current therapy is one of the key reasons for this outcome. Nimbolide (NL), a triterpenoid obtained from Azadirachta indica, exhibits anticancer properties in ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2017.10.029
更新日期：2018-01-28 00:00:00
abstract：:It is well documented that CD44 plays an important role in tumor metastasis. We investigated whether there is a correlation between the expression of its isoforms in prostate cancer cells and patient prognosis using 72 cases with biopsy specimens. Immunohistochemistry demonstrated expression of CD44H (68.1%), v6 (36.1...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(98)00088-3
更新日期：1998-07-03 00:00:00
