Abstract:
:The three most common genetic abnormalities occurring in malignant lymphomas involve alterations resulting in the deregulated expression of the c-myc and bcl-2 oncogenes and the inactivation of the p53 tumor suppressor gene. Relevant strains of genetically engineered mice, including bcl-2-Ig and E mu-myc transgenic mice and p53 knockout mice, have been used to prospectively examine the regulation of apoptotic cell death by these genes, individually and in combination, and their contribution to in vivo lymphomagenesis. The potential importance of the therapeutic induction of apoptosis is discussed.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Hsu B,Marin MC,McDonnell TJdoi
10.1016/0304-3835(95)03836-lsubject
Has Abstractpub_date
1995-07-20 00:00:00pages
17-23issue
1eissn
0304-3835issn
1872-7980pii
030438359503836Ljournal_volume
94pub_type
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