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Different ras gene mutational frequencies in thyroid papillary carcinomas in Japan and Thailand.

Abstract：

:The incidence and pattern of ras oncogene mutations in human malignancies demonstrate geographic and racial differences. For example, specificity of alterations is found in cholangiocellular carcinomas in Thai patients with a different etiology from those in Japanese patients. In the present study, a comparison of ras gene mutations in thyroid papillary carcinomas from Japanese and Thai patients was performed using single-strand conformation polymorphism and direct sequencing analyses. The incidence of ras mutation differed markedly in Japanese (two of 24 carcinomas, 8.3%) and Thai (five of 10 carcinomas, 50%) patients. In addition, all but one ras mutation occurred at codon 12 of the K-ras gene in the Thai cases. These results suggest that thyroid cancers in Thailand may be due to specific genetic and/or environmental factors.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Naito H,Pairojkul C,Kitahori Y,Yane K,Miyahara H,Konishi N,Matsunaga T,Hiasa Y

doi

10.1016/s0304-3835(98)00149-9

subject

Has Abstract

pub_date

1998-09-25 00:00:00

pages

171-5

issue

2

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(98)00149-9

journal_volume

131

pub_type

杂志文章

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