Abstract：
:We investigated the molecular mechanisms involved in the anti-proliferative activity exerted by conjugated linoleic acid (CLA) on the estrogen unresponsive MDA-MB-231 human breast cancer cell line. The effects on cell proliferation, cell cycle progression and induction of apoptosis were examined. CLA caused the reduction of cell proliferation along with the accumulation of cells in the S phase of the cycle. The occurrence of apoptosis in these cells was indicated by flow cytometry data and further confirmed by the onset of cells with morphological features typical of apoptosis. ERK1/2 reduction and upregulation of pro-apoptotic protein Bak were induced. These events were associated with: (a) reduced levels of the anti-apoptotic protein Bcl-x(L), (b) the translocation of cytochrome c from the mitochondria to the cytosol, (c) the cleavage of pro-caspase-9 and pro-caspase-3. From the above data, we are induced to think that CLA may trigger apoptosis in the estrogen unresponsive MDA-MB-231 cell line via mechanisms involving above all the mitochondrial pathway.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Miglietta A,Bozzo F,Bocca C,Gabriel L,Trombetta A,Belotti S,Canuto RAdoi
10.1016/j.canlet.2005.03.029keywords:
subject
Has Abstractpub_date
2006-03-28 00:00:00pages
149-57issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(05)00280-6journal_volume
234pub_type
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