Abstract:
:The thiol N-acetylcysteine (NAC), a precursor of intracellular glutathione (GSH), efficiently prevented the induction of lung tumors in Swiss albino mice, when supplemented to the diet (0.2%) both before and after an i.p. injection of the carcinogen urethan (ethyl carbamate). Irrespective of urethan administration, NAC also significantly enhanced GSH S-transferase activity in liver preparations of the same animals. These data show that, under certain conditions, it is possible to prevent chemically induced cancer by increasing the levels of physiological trapping agents.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
De Flora S,Astengo M,Serra D,Bennicelli Cdoi
10.1016/0304-3835(86)90175-8subject
Has Abstractpub_date
1986-09-01 00:00:00pages
235-41issue
3eissn
0304-3835issn
1872-7980pii
0304-3835(86)90175-8journal_volume
32pub_type
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